Results 41 to 50 of about 10,005 (213)

NMN maintained the chromosome morphology of aged porcine oocytes.

, 2023
(A) Representative confocal images of normal and abnormal spindles and DNA. (B, C) The ratio of abnormal spindle and misaligned chromosome at 0 h, AGED-24 h, AGED+NMN-24 h, AGED-48 h and AGED+NMN-48 h oocytes.
Meng Zhang (154027), Ziyi Li (349831), Qinghe Han (3334569), Bo Tang (23472), Xinglan An (4710140), Sheng Zhang (111330), Yurong Chen (9295328), Leyi Li (5141735), Luyao Wang (3958562), Yanhui Zhai (4710142), Xiangpeng Dai (347455), Guanghong Xie (560131)   +11 more
core   +1 more source

Single bolus injection of nicotinamide mono nucleotide increases systemic insulin sensitivity in association with activation of NAD salvage pathway in the liver and adipose tissue in mice

Endocrine Journal
Rising nicotinamide adenine dinucleotide (NAD+) levels mitigate the onset and progression of age-related diseases including metabolic disorders.
Shunsuke Hiroshige, Yasuko Kajimura, Yuko Nagao, Akihiko Taguchi, Ryoko Hatanaka, Chika Yodokawa, Yuka Fujioka, Masaru Akiyama, Yukio Tanizawa, Yasuharu Ohta   +9 more
doaj   +1 more source

NMN reduced the level of ROS in aged porcine oocytes.

, 2023
Images (A) and ROS level (B) at 0 h, AGED-24 h, AGED+NMN-24 h, AGED-48 h and AGED+NMN-48 h oocytes. Scale bars represented 100 μm. The expression of anti‐oxidative stress genes SOD1 (C) and Cat (D) in fresh and aged oocytes.
Meng Zhang (154027), Ziyi Li (349831), Qinghe Han (3334569), Bo Tang (23472), Xinglan An (4710140), Sheng Zhang (111330), Yurong Chen (9295328), Leyi Li (5141735), Luyao Wang (3958562), Yanhui Zhai (4710142), Xiangpeng Dai (347455), Guanghong Xie (560131)   +11 more
core   +1 more source

Rhoifolin Alleviates Ulcerative Colitis by Targeting NMNAT1 and Activating SIRT1‐FOXO1 Signaling to Enhance ILC3s Effector Function

Advanced Science, EarlyView.
Rhoifolin directly targets NMNAT1, thereby activating nicotinamide salvage pathway and promoting intracellular NAD+ biosynthesis. Elevated NAD+ levels enhance SIRT1 activity, leading to FOXO1 deacetylation and nuclear translocation. Nuclear FOXO1 subsequently binds to the IL‐22 promoter, upregulating IL‐22 transcription and potentiating ILC3 effector ...
Hongqiong Yang, Yishu Zhang, Sijia Feng, Xiaoqing Ma, Jiayi Feng, Junwei Wang, Jialin Gao, An Pan, Dapeng Wu, Kang Ding, Caijuan Zheng, Qi Lv, Lihong Hu   +12 more
wiley   +1 more source

The NMN/NaMN adenylyltransferase (NMNAT) protein family

Frontiers in Bioscience, 2009
NAD biosynthesis has become of considerable interest owing to the important signaling functions of the pyridine nucleotides which have been recognized over the past years. The formation of the dinucleotides from ATP and the mononucleotide of niacin (either nicotinamide or nicotinic acid) constitute the critical step in NAD generation which is catalyzed
Corinna, Lau, Marc, Niere, Mathias, Ziegler   +2 more
openaire   +2 more sources

β-nicotinamide mononucleotide (NMN) production in Escherichia coli [PDF]

Scientific Reports, 2018
AbstractDiabetes is a chronic and progressive disease with continuously increasing prevalence, rising financial pressure on the worldwide healthcare systems. Recently, the insulin resistance, hallmark of type 2 diabetes, was cured in mice treated with NAD+ precursor β-nicotinamide mononucleotide (NMN), no toxic effects being reported.
George Cătălin Marinescu, Roua-Gabriela Popescu, Gheorghe Stoian, Anca Dinischiotu   +3 more
openaire   +2 more sources

Synthesis of NMN by cascade catalysis of intracellular multiple enzymes

RSC Advances, 2023
Three multi-enzyme cascade catalytic pathways were constructed to explore the supply capacity of glucose, xylose, and arabinose to PRPP. 1.8 mM NMN was ultimately produced under optimized conditions using glucose as the substrate.
Wenfeng Hua, Na Jiang, Yifei Wu, Cailian Zhou, Kequan Chen, Xin Wang   +5 more
openaire   +2 more sources

β-Nicotinamide mononucleotide protects against hypervirulent Klebsiella pneumoniae bloodstream infection and liver injury

mSphere
In clinical practice, hypervirulent Klebsiella pneumoniae (hvKP) often causes bloodstream infections (BSI) and liver abscesses; however, the mechanism of hvKP-induced liver abscess formation remains unclear.
Zubai Cao, Bao Meng, Jie Chen, Ruomu Ge, Yanyan Liu, Jiabin Li   +5 more
doaj   +1 more source

Fibrillarin Resists Cellular Senescence Via SIRT1‐Dependent Nicotinamide Metabolism and Its Inhibition Sensitizes Senolytic Therapy in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
FBL directly binds to and stabilizes SIRT1 by blocking its ubiquitin‐proteasome degradation, thereby sustaining nicotinamide metabolism and redox homeostasis to counteract cellular senescence in ESCC. Genetic and pharmacological suppression of FBL sensitizes tumor cells to senolytic therapy.
Xing Jin, Hong Liu, Ling Gao, Lei Liu, Ji‐Bin Liu, Xiaoxia Jin, Ming‐Song Wang, Dan Liu, Li Feng, Wen‐Lian Chen   +9 more
wiley   +1 more source

Nicotinamide mononucleotide production by non-recombinant Limosilactobacillus reuteri and nicotinamide adenine dinucleotide synthesizing lactic acid bacteria

Microbiology Spectrum
β-nicotinamide mononucleotide (NMN) is a precursor of nicotinamide adenine dinucleotide (NAD+) and has the potential to suppress aging. Certain strains of lactic acid bacteria (LAB) can produce cofactors and vitamins through fermentation.
Satoru Ozaki, Yoshiko Honme, Masashi Morifuji   +2 more
doaj   +1 more source