β-Nicotinamide mononucleotide protects against hypervirulent Klebsiella pneumoniae bloodstream infection and liver injury [PDF]
mSphereIn clinical practice, hypervirulent Klebsiella pneumoniae (hvKP) often causes bloodstream infections (BSI) and liver abscesses; however, the mechanism of hvKP-induced liver abscess formation remains unclear.
Zubai Cao +5 more
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Enhanced Production of β-Nicotinamide Mononucleotide with Exogenous Nicotinamide Addition in Saccharomyces boulardii-YS01 [PDF]
Foods, 2023 β-Nicotinamide mononucleotide (NMN), as a key precursor of an essential coenzyme nicotinamide adenine dinucleotide (NAD+), is most recognized for its pathological treatment effects and anti-aging functions.
Meijie Song +6 more
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Metabolic engineering of Escherichia coli for biosynthesis of β‐nicotinamide mononucleotide from nicotinamide [PDF]
Microbial Biotechnology, 2021 Summary The β‐nicotinamide mononucleotide (NMN) is a key intermediate of an essential coenzyme for cellular redox reactions, NAD. Administration of NMN is reported to improve various symptoms, such as diabetes and age‐related physiological decline. Thus,
Yang Liu, Montri Yasawong, Bo Yu
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β-Nicotinamide mononucleotide activates NAD+/SIRT1 pathway and attenuates inflammatory and oxidative responses in the hippocampus regions of septic mice [PDF]
Redox Biology, 2023 Sepsis-associated encephalopathy (SAE) is one of the common serious complications in sepsis, and the pathogenesis of SAE remains unclear. Sirtuin 1 (SIRT1) has been reported to be downregulated in the hippocampus and SIRT1 agonists can attenuated the ...
Hui-ru Li +8 more
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β-Nicotinamide mononucleotide activates the SIRT1/NF-κB pathway to alleviate ischemia reperfusion injury after lung transplantation [PDF]
Journal of Translational MedicineBackground Lung ischemia-reperfusion injury (LIRI) is associated with a variety of postoperative complications and affects patient prognosis. β-Nicotinamide mononucleotide (NMN) has attracted much attention due to its potential role in cellular energy ...
Ganggui Zhu +8 more
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Safety evaluation of β-nicotinamide mononucleotide oral administration in healthy adult men and women [PDF]
Scientific Reports, 2022 A decrease in the intracellular level of nicotinamide adenine dinucleotide (NAD+), an essential coenzyme for metabolic activity, causes various age-related diseases and metabolic abnormalities. Both in-vivo and in-vitro studies have shown that increasing
Yuichiro Fukamizu +5 more
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β-Nicotinamide mononucleotide improves chilled ram sperm quality in vitro by reducing oxidative stress damage [PDF]
Animal BioscienceObjective The present study aimed to investigate the effect of β-nicotinamide mononucleotide (NMN) supplementation on ram sperm quality during storage at 4°C in vitro. Methods Tris-citric acid-glucose solution containing different doses of NMN (0, 30, 60,
Zhendong Zhu +6 more
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β-nicotinamide mononucleotide rescues the quality of aged oocyte and improves subsequent embryo development in pigs [PDF]
PLoS ONE, 2023 Oocyte senescence alters the shape and function, thereby weakening the fertilization potential. Nicotinamide mononucleotide (NMN) reverses age-related dysfunctions in various organs.
Leyi Li +11 more
doaj +5 more sources
β-Nicotinamide Mononucleotide Inhibits Cellular Senescence in Mouse C2C12 Skeletal Muscle Cells [PDF]
Journal of Aging Researchβ-Nicotinamide mononucleotide (NMN), as the precursor of nicotinamide adenine dinucleotide (NAD+), has remarkable therapeutic potential in aging-associated diseases.
Jing Mi +8 more
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β-Nicotinamide mononucleotide preserves muscle strength in septic male mice [PDF]
Scientific ReportsSepsis remains a leading cause of mortality and long-term disability, with survivors frequently developing intensive care unit–acquired weakness (ICU-AW) as part of post-intensive care syndrome.
Mari Saida +8 more
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