β-Nicotinamide Mononucleotide Alleviates Hydrogen Peroxide-Induced Cell Cycle Arrest and Death in Ovarian Granulosa Cells [PDF]
Int J Mol Sci, 2023 Maintaining normal functions of ovarian granulosa cells (GCs) is essential for oocyte development and maturation. The dysfunction of GCs impairs nutrition supply and estrogen secretion by follicles, thus negatively affecting the breeding capacity of farm
Yunduan Wang +13 more
semanticscholar +2 more sources
β-Nicotinamide mononucleotide alleviates Alcohol-Induced liver injury in a mouse model through activation of NAD+/SIRT1 signaling pathways [PDF]
HereditasAlcoholism is a significant contributor to the development of alcoholic liver disease, for which no universally accepted and effective treatment currently exists.
Xin-Xin Yang +5 more
semanticscholar +2 more sources
Oral MIB‐626 (β Nicotinamide Mononucleotide) Safely Raises Blood Nicotinamide Adenine Dinucleotide Levels in Hospitalized Patients With COVID‐19 and Acute Kidney Injury: A Randomized Controlled Trial [PDF]
FASEB BioadvNicotinamide adenine dinucleotide (NAD+) plays an important role in the innate immune response and is depleted during SARS‐CoV‐2 infection due to increased turnover.
K. Pencina +15 more
semanticscholar +2 more sources
β-Nicotinamide Mononucleotide (NMN) Administrated by Intraperitoneal Injection Mediates Protection Against UVB-Induced Skin Damage in Mice [PDF]
J Inflamm Res, 2021 Objective Ultraviolet light is an important environmental factor that induces skin oxidation, inflammation, and other diseases. Nicotinamide mononucleotide (NMN) has the effect of anti-oxidation and improving various physiological processes.
Xian-Rong Zhou +6 more
semanticscholar +2 more sources
Journal of Cardiovascular Pharmacology and TherapeuticsMicrogravity conditions cause myocardial atrophy and dysfunction with limited therapeutics. Accumulating evidence demonstrates that the deficiency of nicotinamide adenine dinucleotide (NAD + ) contributes to myocardial dysfunction under microgravity ...
Wenyu Gu MSc +7 more
doaj +2 more sources
A sustained-release depot formulation of β-nicotinamide mononucleotide for alleviating chemotherapy-induced myelosuppression [PDF]
Mater Today BioChemotherapy-induced myelosuppression (CIM) is characterized by impaired hematopoietic function and a sharp decline in peripheral blood cell counts.
Bin Yu +10 more
semanticscholar +2 more sources
β-nicotinamide mononucleotide (NMN) production in Escherichia coli [PDF]
Sci Rep, 2018 Diabetes is a chronic and progressive disease with continuously increasing prevalence, rising financial pressure on the worldwide healthcare systems.
G. Marinescu +3 more
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Safety of beta‐nicotinamide mononucleotide (β‐NMN) pursuant the regulation (EU) 2015/2283 and the bioavailability of nicotinamide from this source in the context of Directive 2002/46/EC [PDF]
EFSA JournalFollowing a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on beta‐nicotinamide mononucleotide (β‐NMN) as a novel food (NF) pursuant to Regulation (EU) 2015/2283 ...
EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) +27 more
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Ingestion of β-nicotinamide mononucleotide increased blood NAD levels, maintained walking speed, and improved sleep quality in older adults in a double-blind randomized, placebo-controlled study [PDF]
GeroscienceM. Morifuji +3 more
semanticscholar +2 more sources
Microbial Biotechnologyβ‐Nicotinamide mononucleotide (NMN) is a precursor of NAD+ in mammals. Research on NAD+ has demonstrated its crucial role against aging and disease. Here two technical paths were established for the efficient synthesis of NMN in the yeast Pichia pastoris,
Yanna Ren +5 more
doaj +2 more sources