Results 31 to 40 of about 900,428 (178)
Metabolic Engineering of Escherichia coli for the Production of β-Nicotinamide Mononucleotide [PDF]
Shipin Kexue, 2023 A modular metabolic engineering for Escherichia coli was designed for efficient production of β-nicotinamide mononucleotide (β-NMN). First, eight enzymes involved in the shunt metabolic pathways of nicotinamide (NAM) and β-NMN were inactivated to reduce ...
AN Junxia, WANG Qianqian, WANG Zhaoying, LIU Huan, XU Qingyang, FAN Xiaoguang
doaj +1 more source
Heterologous Expression and Enzymatic Properties of Nicotinamide Nucleoside Kinase from Saccharomyces cerevisiae [PDF]
Shipin Kexue, 2023 In this study, the nicotinamide riboside kinase 1 gene (ScNRK1) was cloned from Saccharomyces cerevisiae, and its soluble expression in Escherichia coli was achieved using pET28a plasmid. The enzyme activity in the fermentation broth was 14.75 IU/mL, and
HE Jianju, LIU Xinxin, SHI Hongling, RAN Luni, WANG Xian, ZHANG Yingjun, TANG Cunduo
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Advance in Understanding the Effect of β-Nicotinamide Mononucleotide on Physiological Functions [PDF]
Shipin Kexue, 2023 The overweight or obese population in sub-health status and the aging population in China are increasing year by year. The intracellular level of nicotinamide adenine dinucleotide (NAD+) decreases dramatically with age and obesity. NAD+ is the key target
CHEN Tao, CAO Hui, DONG Li, JI Zhe, CAO Jianmin
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Determination of β-Nicotinamide Mononucleotide (NMN) in NMN Cross Border Products
Shipin gongye ke-ji, 2022 By optimizing the chromatographic conditions and sample pretreatment conditions, a method for determination of NMN content in NMN capsules and NMN tablets matrix was established based on high performance liquid chromatography, and the methodology was ...
Wenyu ZHANG +8 more
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Nature Communications, 2022 Age-dependent decline in remyelination in the CNS is associated with declined differentiation capacity of oligodendrocyte progenitor cells (OPCs). Here, the authors show nuclear entry of SIRT2 is impaired and NAD+ levels are reduced during ageing in ...
Xiao-Ru Ma +24 more
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Bioresources and Bioprocessing, 2022 Background β-Nicotinamide mononucleotide (NMN) is the direct precursor of nicotinamide coenzymes such as NAD+ and NADP+, which are widely applied in industrial biocatalysis especially involving cofactor-dependent oxidoreductases.
Xiao-Long Qian +5 more
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Effect of a mixture of caffeine and nicotinamide on the solubility of vitamin (B2) in aqueous solution [PDF]
, 2006 The effect of caffeine (CAF) and nicotinamide (NMD) on the solubility of a vitamin B2 derivative (FMN) has been evaluated for mixtures containing either a single hydrotrope (CAF or NMD) or the two hydrotropes simultaneously.
Davies, David B. +3 more
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Review on Biosynthesis of β-Nicotinamide Mononucleotide and Its Derivatives [PDF]
Shipin Kexueβ-Nicotinamide mononucleotide (NMN) is present in all organisms and has attracted widespread attention as a nutritional supplement and pharmaceutical product for the treatment of various diseases, such as Alzheimer’s disease, cancer, aging, and vascular ...
WANG Zhaoying, GUO Xinhao, HUANG Xinhe, CHEN Zhuoyan, LIU Yueqi, LI Juan, CHEN Ning, FAN Xiaoguang
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Increased glycolysis affects β-cell function and identity in aging and diabetes
Molecular Metabolism, 2022 Objective: Age is a risk factor for type 2 diabetes (T2D). We aimed to elucidate whether β-cell glucose metabolism is altered with aging and contributes to T2D.
Naoya Murao +5 more
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Frontiers in Bioengineering and Biotechnology, 2023 Nicotinamide riboside kinase (NRK) plays an important role in the synthesis of β -nicotinamide nucleotide (NMN). NMN is a key intermediate of NAD+ synthesis, and it actually contribute to the well-being of our health.
Jian-Ju He +14 more
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