Results 41 to 50 of about 900,428 (178)

Nicotinamide mononucleotide: a potential effective natural compound against insulin resistance

, 2021
Recently, a study published in Science by Yoshino et al.1 reported on a randomized, placebo-controlled, double-blind clinical trial to examine the effects of a 10-week nicotinamide mononucleotide (NMN) administration on human metabolism in 25 ...
Roos, Julian, Pamela Fischer-Posovszky, Julia Zinngrebe, Fischer-Posovszky, Pamela, Zinngrebe, Julia, Julian Roos   +5 more
core   +1 more source

Human Nmnat1 Promotes Autophagic Clearance of Amyloid Plaques in a Drosophila Model of Alzheimer’s Disease

Frontiers in Aging Neuroscience, 2022
Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by irreversible cognitive decline with limited therapeutic approaches. We characterized a Drosophila model of amyloid pathology that expresses human amyloid-beta precursor ...
Yi Zhu, Amanda G. Lobato, R. Grace Zhai, Milena Pinto   +3 more
doaj   +1 more source

Effects of TND1128 (a 5-deazaflavin derivative), with self-redox ability, as a mitochondria activator on the mouse brain slice and its comparison with β-NMN

Journal of Pharmacological Sciences, 2023
We have no definitive treatment for dementia characterized by prolonged neuronal death due to the enormous accumulation of foreign matter, such as β-amyloid.
Nanae Takahashi, Norio Akaike, Tomohisa Nagamatsu, Hiroyuki Uchino, Yoshihisa Kudo   +4 more
doaj   +1 more source

Enzymatic Synthesis of Polymers Containing Nicotinamide Mononucleotide [PDF]

, 1995
Nicotinamide mononucleoside 5'-diphosphate in its reduced form is an excellent substrate for polynucleotide phosphorylase from Micrococcus luteus both in de novo polymerization reactions and in primer extension reactions.
Liu, Rihe, Orgel, Leslie E.
core   +2 more sources

Comprehensive Transformation of Escherichia coli for Nicotinamide Mononucleotide Production

, 2023
Nicotinamide mononucleotide (NMN) is a key precursor of nicotinamide adenine dinucleotide and an important source of cellular energy. It can prevent neuronal mitochondrial defects and alleviate heart fibrosis.
Linyan Yang, Tianjiao Bi, Tao Wu, Yan Xu, Xiaoqing Mu   +4 more
core   +1 more source

NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells [PDF]

, 2016
NAD+ is a vital redox cofactor and a substrate required for activity of various enzyme families, including sirtuins and poly(ADP-ribose) polymerases. Supplementation with NAD+ precursors, such as nicotinamide mononucleotide (NMN) or nicotinamide riboside
Boutant, Marie, Migaud, Marie E., Ratajczak, Joanna, Ras, Rosa, Trammell, Samuel A. J., Auwerx, Johan, Trammell, Samuel A.J., Kulkarni, Sameer S., Yanes, Oscar, Joffraud, Magali, Trammell, Samuel A J, Rodrigues, Marcelo, Redpath, Philip, Canela, Nuria, Brenner, Charles, Cantó, Carles   +15 more
core   +3 more sources

Structure of nicotinamide mononucleotide adenylyltransferase: a key enzyme in NAD+ biosynthesis [PDF]

, 2000
Background: Nicotinamide adenine dinucleotide (NAD+) is an essential cofactor involved in fundamental processes in cell metabolism. The enzyme nicotinamide mononucleotide adenylyltransferase (NMN AT) plays a key role in NAD+ biosynthesis, catalysing the ...
Menico Rizzi, Teresa Lorenzi, Valerio Dabusti, Rizzi, Menico, D’Angelo, Igor, Lorenzi, Teresa, Dabusti, Valerio, Raffaelli, Nadia, Giulio Magni, Igor D’Angelo, Nadia Raffaelli, Magni, Giulio   +11 more
core   +1 more source

Effect of β-Nicotinamide Mononucleotide on the Growth Promotion of Caenorhabditis elegans and Its Mechanism

Shipin gongye ke-ji, 2023
Objective: To study the effect of β-nicotinamide mononucleotide (NMN) on the growth of Caenorhabditis elegans (C. elegans) and its mechanism. Methods: Nematodes were randomly divided into blank control group and experimental groups with different ...
Shu LI, Yuqin TONG, Shulin YANG, Yang YANG, Mansi NIU, Fuli WEN, Shan ZENG, Caihong SHEN, Jian ZHAO, Songtao WANG   +9 more
doaj   +1 more source

SDF‐1 Attenuates Oocyte Quality Decline During Reproductive Aging Through Autophagy‐Enhanced Stress Granule Scavenging

Advanced Science, EarlyView.
SDF‐1 levels decline significantly with maternal aging. Exogenous supplementation restores meiotic spindle morphology, chromosomal alignment, and mitochondrial function while reducing oxidative stress in aged oocytes. Mechanistically, SDF‐1 enhances autophagic activity to clear accumulated stress granules, thereby rescuing fertilization competence and ...
Rui Long, Meng Wang, Ruolin Mao, Hong Chen, Juepu Zhou, Xiangfei Wang, Zheng Yuan, Ri‐Cheng Chian, Nan Xiao, Qingsong Xi, Yimin Shu, Lei Jin, Lixia Zhu   +12 more
wiley   +1 more source

Engineering a nicotinamide mononucleotide redox cofactor system for biocatalysis. [PDF]

, 2020
Biological production of chemicals often requires the use of cellular cofactors, such as nicotinamide adenine dinucleotide phosphate (NADP+). These cofactors are expensive to use in vitro and difficult to control in vivo.
Cui, Youtian, Fong, Bonnie, Maxel, Sarah, King, Edward, Siegel, Justin B, Li, Han, Zhang, Linyue, Mak, Wai Shun, Black, William B, Sanchez Martinez, Alicia   +9 more
core   +1 more source