Results 61 to 70 of about 10,005 (213)

A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration [PDF]

, 2015
NAD metabolism regulates diverse biological processes, including ageing, circadian rhythm and axon survival. Axons depend on the activity of the central enzyme in NAD biosynthesis, nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2), for their ...
Janeckova, L, Vargas, M. E, Meng, W, L A Worrell, ORSOMANDO, Giuseppe, G Orsomando, L Janeckova, A Sagasti, Pucciarelli, S, Sagasti, A, MORI, VALERIO, Vargas, ME, Worrell, L. A, L Conforti, Di Stefano, M, Webster, JRM, Magni, G, M P Coleman, Worrell, LA, S Pucciarelli, PUCCIARELLI, Stefania, Carpi, F. M, MAGNI, GIULIO, A Loreto, I Nascimento-Ferreira, J Tickle, V Mori, Ribchester, R. R, Tickle, J, Orsomando, G, Brown, R, Conforti, L, Webster, J. R. M, Conforti, L., R R Ribchester, W Meng, Nascimento-Ferreira, I, M E Vargas, J Gilley, Marangoni, M, M Marangoni, F M Carpi, Carpi, FM, Coleman, MP, Mori, V, Gilley, J, Ribchester, RR, M Di Stefano, Nascimento Ferreira, I, Rossi, F, J Patrick, Loreto, A, Patrick, J, F Rossi, G Magni, R Brown, J R M Webster, Coleman, M. P   +57 more
core   +2 more sources

Effects of NAD+ booster NMN on ovarian function and late-life bone health [PDF]

, 2022
Ovarian ageing is a major health concern with socioeconomic consequences, manifesting at the comparatively young age of around 35 years. In cancer patients who have undergone chemotherapy, this process is greatly accelerated and can lead to premature ...
Marinova, Maria
core   +1 more source

Progress report on new epilepsy treatments: A summary of the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII). II. Treatments in more advanced clinical development

Epilepsia, EarlyView.
Abstract This article summarizes data for 13 investigational treatments for which at least preliminary seizure outcome data in patients with epilepsy were reported at the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices held in Madrid, Spain, on May 3–6, 2026.
Meir Bialer, Cecilie Johannessen Landmark, Matthias J. Koepp, Emilio Perucca, Piero Perucca, Torbjörn Tomson, H. Steve White, Elaine Wirrell   +7 more
wiley   +1 more source

Transcriptome-guided engineering of a native niacin transporter in Lactiplantibacillus plantarum unveils metabolic rewiring for NMN biosynthesis

Frontiers in Microbiology
Introductionβ-nicotinamide mononucleotide (NMN), a precursor of NAD+, holds promise as a functional food ingredient for mitigating age-related decline.
Linghui Kong, Xinyu Li, Qing He, Qingshou Yao, Lianzhong Ai, Jiayang Qin   +5 more
doaj   +1 more source

Plasma free metanephrine and normethanephrine levels correlated to plasma catecholamine after acute running in amateur runner

Journal of Exercise Science & Fitness, 2021
Background/Objective: Catecholamine is a typical index of exercise intensity, but it is difficult to detect. Plasma metanephrine (MN) and normethanephrine (NMN) levels are more stable than those of catecholamines.
Katsuyuki Tokinoya, Yasuhiro Shishikura, Nanami Sekine, Atsushi Aoyagi, Yasuko Yoshida, Yuichi Aita, Takehito Sugasawa, Yoshiharu Nabekura, Kazuhiro Takekoshi   +8 more
doaj   +1 more source

Design Internal Forces of Non‐Dissipative Members in CBFs With Regular and Irregular Brace Configurations

Earthquake Engineering &Structural Dynamics, EarlyView.
ABSTRACT Steel Concentrically Braced Frames (CBFs) are widely used in seismic regions, with chevron and split‐X configurations commonly adopted for their structural efficiency and architectural flexibility. Although extensive research has been carried out on these systems, the effectiveness of the formulations available in the literature for estimating
Melina Bosco, Pier Paolo Rossi
wiley   +1 more source

NAD BIOSYNTHESIS IN HUMAN PLACENTA: CHARACTERIZATION OF HOMOGENEOUS NMN ADENYLYLTRANSFERASE

, 1992
NAD Byosinthesisi in Human Placenta Characterization of Homogeneopus NMN ...
N. Raffaelli, G. Magni, S. Ruggieri, Natalini P., MAGNI, GIULIO, EMANUELLI, Monica, RUGGIERI, Silverio, BALDUCCI, Enrico, P. Natalini, E. Balducci, Balducci E., M. Emanuelli, RAFFAELLI, Nadia   +12 more
core   +2 more sources

Distinctive Gene Expression Profiles and Biological Responses of Skin Fibroblasts to Nicotinamide Mononucleotide: Implications for Longevity Effects on Skin

Biomedicines
Background/Objectives: Enhancement of cellular NAD+ mediated by NMN has emerged as a pivotal strategy in modulating the aging process. This study aimed to systematically investigate the anti-aging effects of NMN on human skin fibroblasts, focusing on how
Seongsu Kang, Jiwon Park, Eunbyul Cho, Dohyun Kim, Sanghyun Ye, Eui Taek Jeong, Seung-Hyun Jun, Nae-Gyu Kang   +7 more
doaj   +1 more source

Disentangling shared and unique effects of parenting on psychopathology: Evidence from two prospective, genetically sensitive cohort studies

JCPP Advances, EarlyView.
Abstract Background Multiple dimensions of parenting–including hostility, conflict, and warmth–are associated with an array of mental disorders in youth. We tested two possible explanations for these associations: Parenting may shape a shared liability to experience many forms of psychopathology (“shared‐liability” hypothesis), or parenting may shape ...
Leah S. Richmond‐Rakerd, Lara Khalifeh, S. Alexandra Burt, Jody M. Ganiban, Rachel E. Hsu, Luke W. Hyde, Sujin Lee, Leslie D. Leve, Misaki N. Natsuaki, Jenae M. Neiderhiser, David Reiss, Daniel S. Shaw, Gabriela L. Suarez, Jasmin Wertz   +13 more
wiley   +1 more source

NMN rescued aged-induced fragmentation of porcine oocytes.

, 2023
(A) Oocyte morphologies and fragmentation rate (B) in aged 0 h, 24 h, and 48 h groups; (C) Oocyte morphologies at CON-48 h and 100 μm NMN groups. The red circles represent aging oocytes; (D) The fragmentation rate of aged 48 h oocytes treated with ...
Meng Zhang (154027), Ziyi Li (349831), Qinghe Han (3334569), Bo Tang (23472), Xinglan An (4710140), Sheng Zhang (111330), Yurong Chen (9295328), Leyi Li (5141735), Luyao Wang (3958562), Yanhui Zhai (4710142), Xiangpeng Dai (347455), Guanghong Xie (560131)   +11 more
core   +1 more source