Results 71 to 80 of about 10,005 (213)

Advancements in NMN biotherapy and research updates in the field of digestive system diseases

Journal of Translational Medicine
Nicotinamide mononucleotide (NMN), a crucial intermediate in NAD + synthesis, can rapidly transform into NAD + within the body after ingestion. NMN plays a pivotal role in several important biological processes, including energy metabolism, cellular ...
Guanyi Liao, Yuchen Xie, Hong Peng, Tianke Li, Xinsen Zou, Faguo Yue, Jinjun Guo, Li Rong   +7 more
doaj   +1 more source

Factors associated with discharge on higher respiratory support for children with tracheostomy hospitalized with bacterial tracheostomy‐associated infections: A prospective, multicenter cohort study

Journal of Hospital Medicine, EarlyView.
Abstract We conducted a multicenter prospective cohort study to identify factors associated with discharge on higher respiratory support in children with tracheostomy hospitalized for bacterial tracheostomy‐associated infections (bTRAINs). We included children 0–21 years with tracheostomy hospitalized for bTRAIN at six freestanding children's hospitals
Krystal S. Jin, Naoko Kono, Jonathan D. Cogen, Sarah Hofman DeYoung, Catherine S. Forster, Andrea Hahn, Margaret Rush, John M. Morrison, Joanna E. Thomson, Sukhada V. Mairal, Michael N. Neely, Wendy J. Mack, Tamara D. Simon, Christopher J. Russell   +13 more
wiley   +1 more source

NMN stimulates autophagy in control hearts.

, 2014
A, Either NMN (500 mg/kg per injection) or vehicle (PBS) was administered (i.p. injection) to Tg-mRFP-GFP-LC3 mice. After 2 hours, the number of fluorescent LC3 dots was evaluated.
Takanobu Yamamoto (573966), Peiyong Zhai (212989), Junichi Sadoshima (106970), Jaemin Byun (573967), Yoshiyuki Ikeda (106953), Shinichi Oka (205454)   +5 more
core   +1 more source

Nuclear matrix-associated NMN adenylyltransferase activity in human placenta

, 1992
This paper presents data about the presence of the NMN adenylyltransferase at the nuclear matrix level of human placenta nuclei. It was found that 40–45% of the activity (depending on the extraction procedure) referred to the total nuclear NMN ...
EMANUELLI M., VITA, Alberto, RAFFAELLI N., NATALINI, Paolo, RUGGIERI S., BALDUCCI, Enrico, MAGNI G.   +6 more
core   +1 more source

Dietary Nicotinamide Mononucleotide, a Key NAD⁺ Intermediate, Alleviates Body Fat Mass and Hypertriglyceridemia by Enhancing Energy Expenditure with Promotion of Fat Oxidation and Hepatic Lipolysis and Suppressing Hepatic Lipogenesis in db/db Mice

Metabolites
Background/Objectives: Supplementation with nicotinamide mononucleotide (NMN), a key nicotinamide adenine dinucleotide (NAD+) intermediate, exerts anti-aging, anti-obesity, and anti-diabetic effects in animal experiments.
Bungo Shirouchi, Sarasa Mitsuta, Mina Higuchi, Mai Okumura, Kazunari Tanaka   +4 more
doaj   +1 more source

Paediatric Melanonychia: Diagnosis and Management

JEADV Clinical Practice, EarlyView.
ABSTRACT Longitudinal melanonychia (LM) in children presents unique diagnostic and management challenges that cannot be adequately addressed by applying adult‐based criteria. Unlike in adults, there are no validated clinical, dermoscopic or histopathologic criteria for predicting nail unit melanoma in the paediatric population.
Angela J. Jiang, Erika Koh, Je‐Ho Mun, Dong‐Youn Lee, Matilde Iorizzo, Adam I. Rubin   +5 more
wiley   +1 more source

Detection and pharmacological modulation of nicotinamide mononucleotide (NMN) in vitro and in vivo [PDF]

Biochemical Pharmacology, 2009
The emerging key role of NAD-consuming enzymes in cell biology has renewed the interest in NAD resynthesis through the rescue pathways. The first step of the nicotinamide-dependent NAD-rescue pathway is operated by nicotinamide phosphoribosyl transferase (NaPRT) forming nicotinamide mononucleotide (NMN).
L. Formentini, MORONI, FLAVIO, CHIARUGI, ALBERTO   +2 more
openaire   +3 more sources

Nicotinamide mononucleotide alleviates endotoxin-induced acute lung injury by modulating macrophage polarization via the SIRT1/NF-κB pathway

Pharmaceutical Biology
Context Sepsis-induced acute lung injury (ALI) is a severe condition with limited effective therapeutics; nicotinamide mononucleotide (NMN) has been reported to exert anti-inflammatory activities.Objective This study explores the potential mechanisms by ...
Simeng He, Xianhong Jiang, Jing Yang, Ya Wu, Jia Shi, Xiaoyang Wu, Shihan Du, Yuan Zhang, Lirong Gong, Shuan Dong, Jianbo Yu   +10 more
doaj   +1 more source

Time‐Resolved Effects of Cold Atmospheric Plasma on E. coli GW‐AmxH19 Transcriptome and Proteome in an Emulated Wastewater Environment

PROTEOMICS, EarlyView.
ABSTRACT Cold atmospheric plasma (CAP) is effective against a variety of microorganisms. Here, we described effects on an Escherichia coli strain isolated from hospital wastewater caused by treatment with physical plasma. E. coli GW‐AmxH19 was incubated in artificial wastewater and treated for 15 min with CAP.
Jörg Bernhardt, Dominik Schneider, Julia Rielicke, Susanne Sievers, Veronika Hahn, Mechthild Bömeke, Anja Poehlein, Dirk Albrecht, Juergen F. Kolb, Katharina Riedel, Rolf Daniel, Daniela Zühlke   +11 more
wiley   +1 more source

Cardioprotection by nicotinamide mononucleotide (NMN): Involvement of glycolysis and acidic pH

, 2017
Stimulation of the cytosolic NAD+ dependent deacetylase SIRT1 is cardioprotective against ischemia-reperfusion (IR) injury. NAD+ precursors including nicotinamide mononucleotide (NMN) are thought to induce cardioprotection via SIRT1.
Yves T. Wang, Paul S. Brookes, Sergiy M. Nadtochiy, Joshua Munger, Keith Nehrke   +4 more
core   +1 more source