Results 11 to 20 of about 10,005 (213)

The NAD+ precursor NMN activates dSarm to trigger axon degeneration in Drosophila [PDF]

eLife, 2022
Axon degeneration contributes to the disruption of neuronal circuit function in diseased and injured nervous systems. Severed axons degenerate following the activation of an evolutionarily conserved signaling pathway, which culminates in the activation ...
Arnau Llobet Rosell, Maria Paglione, Jonathan Gilley, Magdalena Kocia, Giulia Perillo, Massimiliano Gasparrini, Lucia Cialabrini, Nadia Raffaelli, Carlo Angeletti, Giuseppe Orsomando, Pei-Hsuan Wu, Michael P Coleman, Andrea Loreto, Lukas Jakob Neukomm   +13 more
doaj   +7 more sources

The elusive NMN transporter is found

Nature Metabolism, 2019
Strategies to restore levels of the enzyme cofactor nicotinamide adenine dinclueotide (NAD) late in life to maintain health by treatment with NAD precursors, such as nicotinamide mononucleotide (NMN), represent an exciting area of research in aging and age-related diseases.
Wu, LE, Sinclair, DA
openaire   +4 more sources

NMN transport by snake renal tubules: choline effects, countertransport, H+-NMN exchange

American Journal of Physiology-Renal Physiology, 1987
N1-methylnicotinamide (NMN) transport by isolated perfused snake (Thamnophis spp.) proximal renal tubules was examined for effects of choline and evidence of countertransport of organic cations and H+-NMN exchange. Choline had no effect on NMN transport, supporting the concept of multiple organic cation transport processes.
W H, Dantzler, O H, Brokl
openaire   +3 more sources

NMN-VD: A Neural Module Network for Visual Dialog [PDF]

Sensors, 2021
Visual dialog demonstrates several important aspects of multimodal artificial intelligence; however, it is hindered by visual grounding and visual coreference resolution problems. To overcome these problems, we propose the novel neural module network for visual dialog (NMN-VD).
Yeongsu Cho, Incheol Kim
openaire   +5 more sources

The Attenuating Effect of High-Intensity Interval Training and Nicotinamide Mononucleotide Supplementation on Aging-Related Oxidative Stress in Rat's Heart Tissue [PDF]

مجله پژوهش در علوم توانبخشی, 2020
Introduction: Numerous studies have shown attenuating effects of nicotinamide mononucleotide (NMN) and high-intensity interval exercise (HIIT) training on reducing oxidative stress. Therefore, in the present study, we evaluated the effect of HIIT and NMN
Sakineh Taheri, Sajad Arshadi, Abdolali Banaeifar, Vahid Imanipour   +3 more
doaj   +1 more source

Subacute Toxicity Study of Nicotinamide Mononucleotide via Oral Administration

Frontiers in Pharmacology, 2020
Nicotinamide mononucleotide (NMN), a key precursory metabolite of NAD+, has been shown to elevate the cellular level of NAD+ and ameliorate various age-related diseases. Despite these progresses, systemic evaluation pertaining to the subacute toxicity of
Yingnan You, Yingnan You, Yang Gao, Yang Gao, Han Wang, Han Wang, Jingshu Li, Jingshu Li, Xiang Zhang, Zhengjiang Zhu, Nan Liu   +10 more
doaj   +1 more source

Screening of Natural High-producing NMN strains and Microbial Synthesis of NMN by Nampt

Food Nutrition Chemistry, 2023
Nicotinamide mononucleotide (NMN) is an endogenous substance in humans with high safety and thermal stability, and its application in cosmetics, medical health, and functional foods has received widespread attention. However, the synthesis process of NMN has problems such as high cost, time-consuming and low yield, which limits the large-scale ...
Chao Li, Zouguo Long, Haichao Zhang, Yuhui Lin, Liqing Zhao   +4 more
openaire   +1 more source

Nicotinamide mononucleotide ameliorates adriamycin-induced renal damage by epigenetically suppressing the NMN/NAD consumers mediated by Twist2

Scientific Reports, 2022
The activation of nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, Sirt1, after the administration of nicotinamide mononucleotide (NMN) suppresses many diseases. However, the role of NMN and Sirt1 in focal glomerulosclerosis (FSGS) has not
Kazuhiro Hasegawa, Yusuke Sakamaki, Masanori Tamaki, Shu Wakino   +3 more
doaj   +1 more source

The NMN Module Conducts Nodule Number Orchestra [PDF]

iScience, 2020
Legumes control nodule number through nodulation and autoregulation of nodulation (AON) pathways. Nodule Inception (NIN) is essential for rhizobial infection and nodule organogenesis in legumes. The GmNINa-miR172c-NNC1 (NMN) module, which consists of two positive regulators, GmNINa and miR172c, and a suppressor, NNC1, integrates both pathways.
Zhijuan Wang, Lixiang Wang, Yongliang Wang, Xia Li   +3 more
openaire   +3 more sources

SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration

, 2021
Axon degeneration is a central pathological feature of many neurodegenerative diseases. Sterile alpha and Toll/interleukin-1 receptor motif-containing 1 (SARM1) is a nicotinamide adenine dinucleotide (NAD +)-cleaving enzyme whose activation triggers axon
Figley, Matthew D, Saikot, Forhad K, DiAntonio, Aaron, Mosaiab, Tamim, Kobe, Bostjan, Jia, Xinying, Landsberg, Michael J, Ve, Thomas, Mobli, Mehdi, Sasaki, Yo, Hartley-Tassell, Lauren, Milbrandt, Jeffrey, Shi, Yun, Masic, Veronika, Luo, Zhenyao, Manik, Mohammad K, McGuinness, Helen Y, Gu, Weixi, Cunnea, Katie, Bosanac, Todd, Kerry, Philip S, Nanson, Jeffrey D, Holt, Stephanie, Malde, Alpeshkumar K, Hughes, Robert O   +24 more
core   +1 more source