Results 41 to 50 of about 139,842 (299)
Frontiers in Endocrinology, 2022 Cellular senescence is a stress or damage response by which a cell adopts of state of essentially permanent proliferative arrest, coupled to the secretion of a number of biologically active molecules. This senescence-associated secretory phenotype (SASP)
Chisaka Kuehnemann +8 more
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Disease Progression Mediated by Egr-1 Associated Signaling in Response to Oxidative Stress [PDF]
, 2012 When cellular reducing enzymes fail to shield the cell from increased amounts of reactive oxygen species (ROS), oxidative stress arises. The redox state is misbalanced, DNA and proteins are damaged and cellular transcription networks are activated.
Abdulkadir +99 more
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The NAD Kinases of Saccharomyces cerevisiae [PDF]
European Journal of Biochemistry, 1970 Subcellular fractions of a strain of Saccharomyces cerevisiae have been prepared by enzymic digestion of the cell walls, osmotic lysis of the protoplasts and sorbitol density gradient centrifugation of the lysate. The mitochondrial fraction has both NAD‐ and NADH‐phosphorylating enzymes, whilst the cytoplasm contains a single NAD‐specific kinase. These
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Biomolecules, 2022 Cisplatin is an FDA approved anti-cancer drug that is widely used for the treatment of a variety of solid tumors. However, the severe adverse effects of cisplatin, particularly kidney toxicity, restrict its clinical and medication applications. The major
Amany Iskander, Liang-Jun Yan
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It takes two to tango: NAD+ and sirtuins in aging/longevity control [PDF]
, 2016 The coupling of nicotinamide adenine dinucleotide (NAD+) breakdown and protein deacylation is a unique feature of the family of proteins called ‘sirtuins.’ This intimate connection between NAD+ and sirtuins has an ancient origin and provides a ...
Guarente, Leonard, Imai, Shin-ichiro
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Photoactivation of NAD Kinase through Phytochrome [PDF]
Plant Physiology, 1975 The specificities of phosphate donors and the effects of metal chelating agents and divalent metal ions on NAD kinase activation by phytochrome-far red-absorbing form (Pfr) were examined. ATP was the most efficient phosphorylating agent. Uridine 5'-triphosphate, cytidine 5'-triphosphate (CTP), inosine 5'-triphosphate, and guanosine 5'-triphosphate in ...
T, Tezuka, Y, Yamamoto
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Molecular Metabolism, 2017 Objective: Augmenting nicotinamide adenine dinucleotide (NAD+) availability may protect skeletal muscle from age-related metabolic decline. Dietary supplementation of NAD+ precursors nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) appear
Rachel S. Fletcher +13 more
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Circadian clocks and breast cancer [PDF]
, 2016 Circadian clocks respond to environmental time cues to coordinate 24-hour oscillations in almost every tissue of the body. In the breast, circadian clocks regulate the rhythmic expression of numerous genes.
Blakeman, V +3 more
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Kinetic Studies of Pigeon Liver NAD Kinase [PDF]
European Journal of Biochemistry, 1968 A procedure for the purification of NAD kinase from pigeon liver acetone powder is described. Although not homogeneous, the preparation is largely free of enzymes which interfere with the assay of NAD kinase. The kinetics with magnesium as the activating ion are described: from Interrelationships between the kinetic coefficients, the modes of ...
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Molecular characterization of Escherichia coli NAD kinase [PDF]
European Journal of Biochemistry, 2001 NAD kinase was purified to homogeneity from Escherichia coli MG1655. The enzyme was a hexamer consisting of 30 kDa subunits and utilized ATP or other nucleoside triphosphates as phosphoryl donors for the phosphorylation of NAD, most efficiently at pH 7.5 and 60 °C.
S, Kawai +4 more
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