Results 31 to 40 of about 158,607 (300)

The CreC regulator of Escherichia coli, a new target for metabolic manipulations [PDF]

, 2015
The CreBC (carbon source-responsive) two-component regulation system of Escherichia coli affects a number of functions, including intermediary carbon catabolism.
Cabrera Gomez, José Gregorio, Godoy, Manuel Santiago, Nikel, Pablo Ivan, Pettinari, María Julia   +3 more
core   +1 more source

Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells

Cell Reports, 2018
Summary: Highly glycolytic cancer cells prevent intracellular acidification by excreting the glycolytic end-products lactate and H+ via the monocarboxylate transporters 1 (MCT1) and 4 (MCT4).
Don Benjamin, Dimitri Robay, Sravanth K. Hindupur, Jens Pohlmann, Marco Colombi, Mahmoud Y. El-Shemerly, Sauveur-Michel Maira, Christoph Moroni, Heidi A. Lane, Michael N. Hall   +9 more
doaj   +1 more source

Physiological relevance, localization and substrate specificity of the alternative (type II) mitochondrial NADH dehydrogenases of Ogataea parapolymorpha

Frontiers in Microbiology
Mitochondria from Ogataea parapolymorpha harbor a branched electron-transport chain containing a proton-pumping Complex I NADH dehydrogenase and three Type II NADH dehydrogenases (NDH-2).
Hannes Juergens, Álvaro Mielgo-Gómez, Albert Godoy-Hernández, Jolanda ter Horst, Janine M. Nijenhuis, Duncan G. G. McMillan, Duncan G. G. McMillan, Robert Mans   +7 more
doaj   +1 more source

A Toolbox for Quantitative Gene Expression in Varroa destructor: RNA Degradation in Field Samples and Systematic Analysis of Reference Gene Stability.

PLoS ONE, 2016
Varroa destructor is the major pest of Apis mellifera and contributes to the global honey bee health crisis threatening food security. Developing new control strategies to combat Varroa will require the application of molecular biology, including gene ...
Ewan M Campbell, Catriona H McIntosh, Alan S Bowman   +2 more
doaj   +1 more source

Mitrochondrial NADH dehydrogenase in cystic fibrosis. [PDF]

Proceedings of the National Academy of Sciences, 1979
We have shown that skin fibroblast from patients with cystic fibrosis (CF) and from carriers for CF [heterozygotes (HZ)] consume more O2 than do their controls. When the mitochondrial electron transport inhibitor rotenone was added to the cells, the relative inhibition of O2 consumption was CF greater than HZ greater than controls (P less than 0.005 in
B L, Shapiro, R J, Feigal, L F, Lam
openaire   +2 more sources

Glycolytic reprograming in Salmonella counters NOX2-mediated dissipation of ΔpH. [PDF]

, 2020
The microbial adaptations to the respiratory burst remain poorly understood, and establishing how the NADPH oxidase (NOX2) kills microbes has proven elusive. Here we demonstrate that NOX2 collapses the ΔpH of intracellular Salmonella Typhimurium.
Chakraborty, Sangeeta, Desai, Prerak, Fitzsimmons, Liam, Kim, Ju-Sim, Liu, Lin, McClelland, Michael, Porwollik, Steffen, Vazquez-Torres, Andres   +7 more
core  

In vivo investigation of hyperpolarized [1,3-13C2]acetoacetate as a metabolic probe in normal brain and in glioma. [PDF]

, 2019
Dysregulation in NAD+/NADH levels is associated with increased cell division and elevated levels of reactive oxygen species in rapidly proliferating cancer cells.
Batsios, Georgios, Gillespie, Anne Marie, Le Page, Lydia M, Najac, Chloé, Radoul, Marina, Ronen, Sabrina M, Subramani, Elavarasan, Viswanath, Pavithra   +7 more
core   +3 more sources

Total tissue lactate dehydrogenase activity in endometrial carcinoma [PDF]

, 2008
Lactate dehydrogenase (LDH) is essential for continuous glycolysis necessary for accelerated tumor growth. The aim of this study was to reconsider if assay of total tissue activity of this enzyme could be useful as marker for endometrial carcinoma (EC ...
Abramić, Marija, Babić, Damir, Ilić-Forko, Jadranka, Osmak, Maja, Šimaga, Šumski   +4 more
core   +1 more source

Uncovering evolutionary and phylogenetic relationships in Glyptothorax species through comparative mitochondrial genomics

Journal of Genetic Engineering and Biotechnology
The mitochondrial genome serves as a crucial molecular marker for studying phylogenetic relationships and molecular evolution in fish. Despite their ecological significance in freshwater ecosystems, Glyptothorax fishes have limited evolutionary research,
Somasundaram Iyyappan, Suvadip Ghara, Irfan Ahmad Bhat, Irfan Ahmad Khan, Mohd Ashraf Rather   +4 more
doaj   +1 more source

Lack of complex I activity in human cells carrying a mutation in MtDNA-encoded ND4 subunit is corrected by the Saccharomyces cerevisiae NADH-quinone oxidoreductase (NDI1) gene [PDF]

, 2001
The gene for the single subunit, rotenone-insensitive, and flavone-sensitive internal NADH-quinone oxidoreductase of Saccharomyces cerevisiae (NDI1) can completely restore the NADH dehydrogenase activity in mutant human cells that lack the essential ...
Attardi, Giuseppe, Bai, Yidong, Chan, Elisa, Chomyn, Anne, Hájek, Petr, Matsuno-Yagi, Akemi, Seo, Byoung Boo, Yagi, Takao   +7 more
core   +1 more source