Results 91 to 100 of about 119,483 (255)

Identifying Novel Inhibitors of RpFabG in Typhus-inducing Rickettsia prowazekii [PDF]

open access: yes, 2019
Epidemic typhus is a rickettsial disease that is contracted via ticks and lice found on the flying squirrel. The disease is caused by Rickettsia prowazekii, an intracellular, gram-negative coccobacillus.
Panatpur, Aparna
core   +1 more source

Integrated genomic and transcriptomic approaches reveal oxidative stress adaptation mechanisms in a mesotrione‐resistant Amaranthus tuberculatus biotype

open access: yesPest Management Science, EarlyView.
Integrated GWAS and transcriptomics in a Canadian waterhemp biotype reveal mesotrione resistance is polygenic and metabolically driven. Significant SNPs and 187 herbicide‐responsive genes point to enhanced redox homeostasis, glutathione‐linked detoxification, lipid/secondary metabolism, and oxidative stress responses. Resistance arises from coordinated,
Martin Laforest   +6 more
wiley   +1 more source

Magnesium deficiency-induced changes in organic acid metabolism of Citrus sinensis roots and leaves

open access: yesBiologia Plantarum, 2013
Organic acid (OA) metabolisms are of fundamental importance but very limited data are available on the responses of plant OA metabolisms to Mg-deficiency. Seedlings of Citrus sinensis (L.) Osbeck cv. Xuegan were irrigated with Mg-deficient (0, 50, or 500
L.T. Yang   +5 more
doaj   +1 more source

Thirty years of glyphosate‐resistant crops and weeds: Current situation and future prospects

open access: yesPest Management Science, EarlyView.
Since 1996, when the first glyphosate‐resistant crop was commercialized and the first resistant weed was reported, resistance has expanded globally. This review analyzes emergence patterns across weed species, crops, regions, resistance mechanisms, and herbicides.
Ricardo Alcántara‐de la Cruz   +7 more
wiley   +1 more source

NADP+ is an endogenous PARP inhibitor in DNA damage response and tumor suppression

open access: yesNature Communications, 2019
Cancer cells respond differently to inhibitors of Poly (ADP-ribose) polymerase. Here the authors reveal that ovarian cancer cells with higher cellular NADP+ levels are more sensitive to clinically relevant PARP1 inhibitors and show that NADP+ act as an ...
Chunjing Bian   +9 more
doaj   +1 more source

MTHFD1 controls DNA methylation in Arabidopsis. [PDF]

open access: yes, 2016
DNA methylation is an epigenetic mechanism that has important functions in transcriptional silencing and is associated with repressive histone methylation (H3K9me).
Bischof, Sylvain   +16 more
core   +2 more sources

Xanthatin‐13‐(Pyrrolidine‐2‐Carboxylic Acid), a Sesquiterpene Lactone Isolated From Burdock Leaf, Attenuated Aβ25‐35 Toxicity and Memory Deficits in a Pharmacological Mouse Model of Alzheimer's Disease

open access: yesPhytotherapy Research, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a severe form of dementia, which occurrence increases with age and lifestyle conditions. It is characterized by amyloid protein accumulation forming senile plaques, hyperphosphorylated tau protein forming neurofibrillary tangles, neuroinflammation, and oxidative stress, leading to synapse loss and cell death ...
Charlyne Barry‐Simonnet   +10 more
wiley   +1 more source

Plastidial NADP-Malic Enzymes from grasses: unravelling the way to the C4 specific isoforms [PDF]

open access: yes, 2013
Malic enzyme is present in many plant cell compartments such as plastids, cytosol and mitochondria. Particularly relevant is the plastidial isoform that participates in the C4 cycle providing CO2 to RuBisCO in C4 species.
Alvarez, Clarisa Ester   +3 more
core   +2 more sources

In vitro and in vivo metabolism profiles of cathinone and pseudoephedrine: Discrimination between khat and pseudoephedrine uses

open access: yesJournal of Forensic Sciences, EarlyView.
Abstract In the present study, the metabolism of khat (Catha edulis) and pseudoephedrine was compared with the aim of identifying objective criteria that could be used to discriminate between them for forensic and doping‐control purposes. An in vitro study using human liver microsomes and an in vivo study using rat urine were performed under harmonized
Jong Suk Park   +6 more
wiley   +1 more source

Salinity Induces Granal Development in Bundle Sheath Chloroplasts of NADP-Malic Enzyme Type C4 Plants

open access: yesPlant Production Science, 2009
In NADP-malic enzyme (NADP-ME) type C4 plants, MC chloroplasts have well-developed grana, whereas BSC chloroplasts are generally characterized by highly reduced grana.
Eiji Omoto   +3 more
doaj   +1 more source

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