Results 101 to 110 of about 72,905 (323)

Diagnosis and treatment of occipital brain lesions in children

open access: yesDevelopmental Medicine &Child Neurology, EarlyView.
Occipital brain lesions in children represent a diagnostic challenge due to the large spectrum of etiologies and overlapping clinical features. This review analyses common and less common causes of occipital brain lesions in children, including malformative, vascular, genetic/metabolic, infectious, inflammatory, and neoplastic conditions.
Luca Bartolini   +4 more
wiley   +1 more source

The prognostic IDH1R132 mutation is associated with reduced NADP+-dependent IDH activity in glioblastoma

open access: yesActa Neuropathologica, 2010
Somatic mutations in the isocitrate dehydrogenase 1 gene (IDH1) occur at high frequency in gliomas and seem to be a prognostic factor for survival in glioblastoma patients.
F. Bleeker   +10 more
semanticscholar   +1 more source

Hidden protein disorder: Deciphering the structural organisation and dynamics of a non‐canonical CP12 from the diatom Thalassiosira pseudonana

open access: yesThe FEBS Journal, EarlyView.
The Alphafold model of the atypical CP12 protein from the diatom Thalassiosira pseudonana did not correspond to small‐angle X‐ray scattering (SAXS) data. By combining site‐directed spin labelling electron paramagnetic resonance experiments (SDSL‐EPR) and molecular dynamics (MD) simulations, we deciphered the structural dynamics of this CP12, revealing ...
Alessio Bonucci   +11 more
wiley   +1 more source

Mechanism of cyanobacterial ferredoxin‐dependent flavin thioredoxin reductase reveals thiolate‐FAD charge transfer and catalytic asymmetry in a homodimer

open access: yesThe FEBS Journal, EarlyView.
Ferredoxin‐dependent flavin thioredoxin reductases (FFTRs) regenerate reduced thioredoxin, sustaining dithiol–disulfide exchange reactions that regulate protein activity in select organisms. In cyanobacterial FFTRs, we describe the formation of a thiolate–flavin charge transfer complex, asynchronous reduction of the two FAD cofactors within the ...
Martha Minjarez‐Saenz   +8 more
wiley   +1 more source

The molecular mechanisms of defensive‐grade organic acid biosynthesis in ground beetles

open access: yesInsect Molecular Biology, EarlyView.
Formic acid and methacrylic acid are the primary defensive chemicals in the pygidial gland secretions of Platynus angustatus and Pterostichus moestus, respectively. Comparative transcriptomics suggests the folate cycle and valine catabolism may be involved in the biosynthesis of formic acid and methacrylic acid, respectively.
Adam M. Rork   +3 more
wiley   +1 more source

Controversies in NEN: An ENETS position statement on nutritional support in neuroendocrine neoplasms

open access: yesJournal of Neuroendocrinology, EarlyView.
Abstract Neuroendocrine neoplasms (NEN) themselves and also their treatment may cause malnutrition, inducing changes in physiological behaviour and eventually leading to increased rates of morbidity and mortality. Malnutrition is a common, under‐recognised and under‐treated condition in patients with NEN, and there are limited data available on the ...
Simona Grozinsky‐Glasberg   +53 more
wiley   +1 more source

Biochemical characterization of phosphoenolpyruvate carboxykinases from multiple species of brown algae

open access: yesJournal of Phycology, EarlyView.
Abstract Phosphoenolpyruvate carboxykinase (PEPCK) is involved in the conversion of phosphoenolpyruvate (PEP) to oxaloacetate (OAA). In addition to playing a role in gluconeogenesis in various organisms, PEPCK also functions in the C4 cycle to concentrate CO2 for photosynthesis in some C4 plants.
Jian‐qiang Jin   +3 more
wiley   +1 more source

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