Results 121 to 130 of about 122,170 (318)

Glutaminase‐1 Mediated Glutaminolysis to Glutathione Synthesis Maintains Redox Homeostasis and Modulates Ferroptosis Sensitivity in Cancer Cells

open access: yesCell Proliferation, EarlyView.
GLS1‐mediated glutaminolysis supports GSH synthesis in cancer cells. GLS1 KO increases ROS, downregulates GPX4, and upregulates GPX1, making cells more sensitive to ferroptosis. Combining GLS1 or GPX1 inhibitors with a GPX4 inhibitor synergistically suppresses cancer growth.
Changsen Bai   +13 more
wiley   +1 more source

Diagnosis and treatment of occipital brain lesions in children

open access: yesDevelopmental Medicine &Child Neurology, EarlyView.
Occipital brain lesions in children represent a diagnostic challenge due to the large spectrum of etiologies and overlapping clinical features. This review analyses common and less common causes of occipital brain lesions in children, including malformative, vascular, genetic/metabolic, infectious, inflammatory, and neoplastic conditions.
Luca Bartolini   +4 more
wiley   +1 more source

Hidden protein disorder: Deciphering the structural organisation and dynamics of a non‐canonical CP12 from the diatom Thalassiosira pseudonana

open access: yesThe FEBS Journal, EarlyView.
The Alphafold model of the atypical CP12 protein from the diatom Thalassiosira pseudonana did not correspond to small‐angle X‐ray scattering (SAXS) data. By combining site‐directed spin labelling electron paramagnetic resonance experiments (SDSL‐EPR) and molecular dynamics (MD) simulations, we deciphered the structural dynamics of this CP12, revealing ...
Alessio Bonucci   +11 more
wiley   +1 more source

Mechanism of cyanobacterial ferredoxin‐dependent flavin thioredoxin reductase reveals thiolate‐FAD charge transfer and catalytic asymmetry in a homodimer

open access: yesThe FEBS Journal, EarlyView.
Ferredoxin‐dependent flavin thioredoxin reductases (FFTRs) regenerate reduced thioredoxin, sustaining dithiol–disulfide exchange reactions that regulate protein activity in select organisms. In cyanobacterial FFTRs, we describe the formation of a thiolate–flavin charge transfer complex, asynchronous reduction of the two FAD cofactors within the ...
Martha Minjarez‐Saenz   +8 more
wiley   +1 more source

U.S. Geological Survey External Quality-Assurance Project Report for the National Atmospheric Deposition Program / National Trends Network and Mercury Deposition Network, 2011-12 [PDF]

open access: yes, 2014
The U.S. Geological Survey operated six distinct programs to provide external quality-assurance monitoring for the National Atmospheric Deposition Program (NADP) / National Trends Network (NTN) and Mercury Deposition Network (MDN) during 2011–2012.
Martin, RoseAnn, Wetherbee, Gregory A.
core  

Revealing the pharmacological mechanisms of nao-an dropping pill in preventing and treating ischemic stroke via the PI3K/Akt/eNOS and Nrf2/HO-1 pathways

open access: yesScientific Reports
Nao-an Dropping Pill (NADP) is a Chinese patent medicine which commonly used in clinic for ischemic stroke (IS). However, the material basis and mechanism of its prevention or treatment of IS are unclear, then we carried out this study. 52 incoming blood
Chen Wang   +9 more
doaj   +1 more source

Controversies in NEN: An ENETS position statement on nutritional support in neuroendocrine neoplasms

open access: yesJournal of Neuroendocrinology, EarlyView.
Abstract Neuroendocrine neoplasms (NEN) themselves and also their treatment may cause malnutrition, inducing changes in physiological behaviour and eventually leading to increased rates of morbidity and mortality. Malnutrition is a common, under‐recognised and under‐treated condition in patients with NEN, and there are limited data available on the ...
Simona Grozinsky‐Glasberg   +53 more
wiley   +1 more source

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