Results 131 to 140 of about 239,596 (347)
Integrating Metabolic Modulation and Nanomedicine for Cancer Immunotherapy
Advanced Science, EarlyView.Metabolic rewiring in cancer is mapped across glucose, amino acid, lipid, nucleotide, and mitochondrial pathways, with emphasis on immune regulation. The review integrates mechanisms linking these pathways to tumor progression and therapy resistance, and profiles nanomaterial platforms that both deliver therapeutics and actively reprogram ...
Xiaosu Zhou +7 more
wiley +1 more source
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1996 L M Henderson, J B Chappel
openaire +3 more sources
Advanced Science, EarlyView.This study establishes an efficient oleaginous heterotrophic microalga, Schizochytrium, through chassis optimization and metabolic engineering, significantly enhancing fatty acid titers and productivities. It also identifies a regulatory mechanism that coordinates biomass and lipid synthesis, providing a rational target for metabolic pathway rewiring ...
Fangzhong Wang +7 more
wiley +1 more source
SP1‐Mediated Glycolytic Reprogramming Promotes Tumorigenesis and Progression in Pancreatic Cancer
Advanced Science, EarlyView.Laser capture microdissection‐based proteomics of pancreatic intraepithelial neoplasia (PanIN) identifies specificity protein 1 (SP1) as a key driver of tumorigenesis and progression in pancreatic cancer through glycolytic remodeling. SP1 enhances aerobic glycolysis by transcriptionally activating 6‐phosphofructo‐2‐kinase/fructose‐2,6‐bisphosphatase ...
Hexing Hang +21 more
wiley +1 more source
Pyruvate synthesis from acetyl coenzyme A and carbon dioxide with NADH2 or NADPH2 as electron donors
, 1969 G. Gottschalk, Arpita Chowdhury
openalex +1 more source
Advanced Science, EarlyView.An unusual IRED platform is reported, enabling efficient DKR via reductive amination without any evolutionary engineering. The system accommodates extremely sterically demanding substrates, including naphthyl and quinoline derivatives, delivering naphthyl‐aryl and quinoline‐aryl amine atropisomers with excellent efficiency and stereocontrol (over 80 ...
Zhichao Ni +7 more
wiley +1 more source
Balancing Cell Growth and Product Synthesis for Efficient Microbial Cell Factories
Advanced Science, EarlyView.This review presents state‐of‐the‐art metabolic engineering strategies to balance microbial cell growth and product synthesis in biorefineries. It surveys pathway engineering, dynamic genetic circuits, orthogonal control systems, synthetic microbial consortia, and fermentation optimization, alongside integrative modeling approaches.
Linxia Liu +5 more
wiley +1 more source