Results 111 to 120 of about 175,216 (165)
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Clinical Science, 2015
The mechanism by which reactive oxygen species (ROS) are produced by tumour cells remained incompletely understood until the discovery over the last 15 years of the family of NADPH oxidases (NOXs 1–5 and dual oxidases DUOX1/2) which are structural homologues of gp91phox, the major membrane-bound component of the respiratory burst oxidase of leucocytes.
Krishnendu, Roy +8 more
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The mechanism by which reactive oxygen species (ROS) are produced by tumour cells remained incompletely understood until the discovery over the last 15 years of the family of NADPH oxidases (NOXs 1–5 and dual oxidases DUOX1/2) which are structural homologues of gp91phox, the major membrane-bound component of the respiratory burst oxidase of leucocytes.
Krishnendu, Roy +8 more
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Archives of Biochemistry and Biophysics, 2002
The NADPH oxidase of phagocytes catalyzes the conversion of oxygen to O2(-). This multicomponent enzyme complex contains five essential protein components, two in the membrane and three in the cytosol. Unassembled and inactive in resting phagocytes, the oxidase becomes active after translocation of cytosolic components to the membrane to assemble a ...
B M, Babior, J D, Lambeth, W, Nauseef
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The NADPH oxidase of phagocytes catalyzes the conversion of oxygen to O2(-). This multicomponent enzyme complex contains five essential protein components, two in the membrane and three in the cytosol. Unassembled and inactive in resting phagocytes, the oxidase becomes active after translocation of cytosolic components to the membrane to assemble a ...
B M, Babior, J D, Lambeth, W, Nauseef
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Antioxidants & Redox Signaling, 2006
NADPH oxidases have a distinct cellular localization in the kidney. Reactive oxygen species (ROS) are produced in the kidney by fibroblasts, endothelial cells (EC), vascular smooth muscle cells (VSMC), mesangial cells (MCs), tubular cells, and podocyte cells.
Pritmohinder S, Gill +1 more
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NADPH oxidases have a distinct cellular localization in the kidney. Reactive oxygen species (ROS) are produced in the kidney by fibroblasts, endothelial cells (EC), vascular smooth muscle cells (VSMC), mesangial cells (MCs), tubular cells, and podocyte cells.
Pritmohinder S, Gill +1 more
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The NADPH Oxidase and the Phagosome
2020The key purpose of phagocytosis is the destruction of pathogenic microorganisms. The phagocytes exert a wide array of killing mechanisms that allow mastering the vast majority of pathogens. One of these mechanisms consists in the production of reactive oxygen species inside the phagosome by a specific enzyme, the phagocyte NADPH oxidase. This enzyme is
Hana, Valenta +3 more
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Role of Nadph Oxidase in Atherosclerosis
Future Cardiology, 2008Reactive oxidant species (ROS) seem to play a key role in the atherosclerotic process via a series of molecular changes that lead to macrophage infiltration in the endothelium and eventually to plaque formation. ROS are also implicated in arterial dysfunction via inactivation of nitric oxide, a potent vasodilator and antiaggregating molecule produced ...
VIOLI, Francesco +3 more
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Current Opinion in Immunology, 2004
NADPH oxidase is an enzyme that catalyzes the production of superoxide from oxygen and NADPH. It is a complex enzyme consisting of two membrane-bound components and three components in the cytosol, plus rac 1 or rac 2. Activation of the oxidase involves the phosphorylation of one of the cytosolic components.
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NADPH oxidase is an enzyme that catalyzes the production of superoxide from oxygen and NADPH. It is a complex enzyme consisting of two membrane-bound components and three components in the cytosol, plus rac 1 or rac 2. Activation of the oxidase involves the phosphorylation of one of the cytosolic components.
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Blood, 1999
T HE NADPH OXIDASES are a group of plasma membrane–associated enzymes found in a variety of cells of mesodermal origin. The most thoroughly studied of these is the leukocyte NADPH oxidase, which is found in professional phagocytes and B lymphocytes.
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T HE NADPH OXIDASES are a group of plasma membrane–associated enzymes found in a variety of cells of mesodermal origin. The most thoroughly studied of these is the leukocyte NADPH oxidase, which is found in professional phagocytes and B lymphocytes.
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2019
Reactive oxygen species (ROS) are highly reactive oxygen derivatives. Initially, they were considered as metabolic by-products (of mitochondria in particular), which consistently lead to aging and disease. Over the last decades, however, it became increasingly apparent that virtually all eukaryotic cells possess specifically ROS-producing enzymes ...
Hélène, Buvelot +2 more
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Reactive oxygen species (ROS) are highly reactive oxygen derivatives. Initially, they were considered as metabolic by-products (of mitochondria in particular), which consistently lead to aging and disease. Over the last decades, however, it became increasingly apparent that virtually all eukaryotic cells possess specifically ROS-producing enzymes ...
Hélène, Buvelot +2 more
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Studies on the reaction mechanism of NADPH-adrenodoxin reductase with NADPH.
Journal of biochemistry, 1983The existence of a multi-component equilibrium involving a reversible reaction was demonstrated in the anaerobic reaction of NADPH-adrenodoxin reductase or ferredoxin-NADPH reductase; EC 1.18.1.2 (AdR) with NADPH or in the photoreduction of AdR in the presence of NADP+ and EDTA.
H, Sakamoto +5 more
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1988
Using the method of enzymic cycling, the dynamics of pyridine nucleotide concentrations in maize roots and cultured carrot cells after various treatments were studied. The changes were related to transplasmamembrane electron- and proton- transfer rates measured by a pH — redoxstat.
Susanne Krüger, Michael Böttger
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Using the method of enzymic cycling, the dynamics of pyridine nucleotide concentrations in maize roots and cultured carrot cells after various treatments were studied. The changes were related to transplasmamembrane electron- and proton- transfer rates measured by a pH — redoxstat.
Susanne Krüger, Michael Böttger
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