Results 21 to 30 of about 95,385 (310)

NADPH Oxidase 1 Is Associated with Altered Host Survival and T Cell Phenotypes after Influenza A Virus Infection in Mice. [PDF]

PLoS ONE, 2016
The role of the reactive oxygen species-producing NADPH oxidase family of enzymes in the pathology of influenza A virus infection remains enigmatic. Previous reports implicated NADPH oxidase 2 in influenza A virus-induced inflammation. In contrast, NADPH
Amelia R Hofstetter, Juan A De La Cruz, Weiping Cao, Jenish Patel, Jessica A Belser, James McCoy, Justine S Liepkalns, Samuel Amoah, Guangjie Cheng, Priya Ranjan, Becky A Diebold, Wun-Ju Shieh, Sherif Zaki, Jacqueline M Katz, Suryaprakash Sambhara, J David Lambeth, Shivaprakash Gangappa   +16 more
doaj   +1 more source

NADPH Oxidase-Derived Reactive Oxygen Species Are Involved in the HL-60 Cell Monocytic Differentiation Induced by Isoliquiritigenin

Molecules, 2012
The present study was undertaken to test the hypothesis that NADPH oxidase-derived reactive oxygen species (ROS) are involved in isoliquiritigenin (ISL)-induced monocytic differentiation in human acute promyelocytic leukemia HL-60 cells.
Qiusheng Zheng, Zhenhua Wang, Xiaoyu Chen, Bo Zhang, Na Chen, Ying Yao, Hongmei Chen, Hui Tian   +7 more
doaj   +1 more source

Annexin peptide Ac2-26 suppresses TNFα-induced inflammatory responses via inhibition of Rac1-dependent NADPH oxidase in human endothelial cells. [PDF]

PLoS ONE, 2013
The anti-inflammatory peptide annexin-1 binds to formyl peptide receptors (FPR) but little is known about its mechanism of action in the vasculature. Here we investigate the effect of annexin peptide Ac2-26 on NADPH oxidase activity induced by tumour ...
Hitesh M Peshavariya, Caroline J Taylor, Celeste Goh, Guei-Sheung Liu, Fan Jiang, Elsa C Chan, Gregory J Dusting   +6 more
doaj   +1 more source

The Role of NADPH Oxidase in Neuronal Death and Neurogenesis after Acute Neurological Disorders

Antioxidants, 2021
Oxidative stress is a well-known common pathological process involved in mediating acute neurological injuries, such as stroke, traumatic brain injury, epilepsy, and hypoglycemia-related neuronal injury.
Song Hee Lee, Minwoo Lee, Dong Gyun Ko, Bo Young Choi, Sang Won Suh   +4 more
doaj   +1 more source

Khz (fusion of Ganoderma lucidum and Polyporus umbellatus mycelia) induces apoptosis by increasing intracellular calcium levels and activating JNK and NADPH oxidase-dependent generation of reactive oxygen species. [PDF]

PLoS ONE, 2012
Khz is a compound derived from the fusion of Ganoderma lucidum and Polyporus umbellatus mycelia that inhibits the growth of cancer cells. The results of the present study show that Khz induced apoptosis preferentially in transformed cells and had only ...
Tae Hwan Kim, Ju sung Kim, Zoo haye Kim, Ren Bin Huang, Ren Sheng Wang   +4 more
doaj   +1 more source

Ectopic Expression of an Arabidopsis Calmodulin-Like Domain Protein Kinase-Enhanced NADPH Oxidase Activity and Oxidative Burst in Tomato Protoplasts

Molecular Plant-Microbe Interactions, 2001
Among plant defense responses to pathogen attack, the release of active oxygen species (AOS), termed the oxidative burst, may affect the attacking pathogen and the host plant cells at the infection site, thereby limiting the spread of the pathogen ...
Tim Xing, Xiao-Jing Wang, Kamal Malik, Brian L. Miki   +3 more
doaj   +1 more source

NADPH Oxidase versus Mitochondria-Derived ROS in Glucose-Induced Apoptosis of Pericytes in Early Diabetic Retinopathy

Journal of Ophthalmology, 2010
Objectives. Using apocynin (inhibitor of NADPH oxidase), and Mitoquinol 10 nitrate (MitoQ; mitochondrial-targeted antioxidant), we addressed the importance of mitochondria versus NADPH oxidase-derived ROS in glucose-induced apoptosis of pericytes ...
Nik M. Mustapha, Joanna M. Tarr, Eva M. Kohner, Rakesh Chibber   +3 more
doaj   +1 more source

HMGB1-RAGE pathway drives peroxynitrite signaling-induced IBD-like inflammation in murine nonalcoholic fatty liver disease

Redox Biology, 2017
Recent clinical studies found a strong association of colonic inflammation and Inflammatory bowel disease (IBD)-like phenotype with NonAlcoholic Fatty liver Disease (NAFLD) yet the mechanisms remain unknown.
Varun Chandrashekaran, Ratanesh K. Seth, Diptadip Dattaroy, Firas Alhasson, Jacek Ziolenka, James Carson, Franklin G. Berger, Balaraman Kalyanaraman, Anna Mae Diehl, Saurabh Chatterjee   +9 more
doaj   +1 more source

Inhibition of NADPH oxidase by apocynin prevents learning and memory deficits in a mouse Parkinson's disease model

Redox Biology, 2019
The activation of NADPH oxidase contributes to dopaminergic neurodegeneration and motor deficits in Parkinson's disease (PD). However, whether NADPH oxidase is involved in non-motor symptoms, especially cognitive dysfunction in PD remains unknown.
Liyan Hou, Fuqiang Sun, Ruixue Huang, Wei Sun, Dan Zhang, Qingshan Wang   +5 more
doaj   +1 more source

NADPH Oxidases in Aortic Aneurysms

Antioxidants, 2022
Abdominal aortic aneurysms (AAAs) are a progressive dilation of the infrarenal aorta and are characterized by inflammatory cell infiltration, smooth muscle cell migration and proliferation, and degradation of the extracellular matrix. Oxidative stress and the production of reactive oxygen species (ROS) have been shown to play roles in inflammatory cell
openaire   +3 more sources