NADPH Oxidase–Dependent Superoxide Production Is Associated With Carotid Intima-Media Thickness in Subjects Free of Clinical Atherosclerotic Disease [PDF]
, 2005 Objective—Oxidative stress plays a critical role in the pathogenesis of atherosclerosis. The NADPH oxidase constitutes the main source of superoxide in phagocytic and vascular cells.
Beloqui, O. (Óscar) +5 more
core +1 more source
NADPH oxidase and enhanced superoxide generation in intrauterine undernourished rats: involvement of the renin-angiotensin system [PDF]
, 2003 Objective: We previously reported that intrauterine undernutrition increased the oxidative stress by decreasing superoxide dismutase activity. in the present study, we tested whether NADPH oxidase, xanthine oxidase, cyclooxygenase or nitric oxide ...
Akamine, E. H. +6 more
core +1 more source
NADPH Oxidases in Aortic Aneurysms
Antioxidants, 2022 Abdominal aortic aneurysms (AAAs) are a progressive dilation of the infrarenal aorta and are characterized by inflammatory cell infiltration, smooth muscle cell migration and proliferation, and degradation of the extracellular matrix. Oxidative stress and the production of reactive oxygen species (ROS) have been shown to play roles in inflammatory cell
openaire +3 more sources
NADPH oxidase activation regulates apoptotic neutrophil clearance by murine macrophages.
Blood, 2018 The phagocyte reduced NAD phosphate (NADPH) oxidase generates superoxide, the precursor to reactive oxygen species (ROS) that has both antimicrobial and immunoregulatory functions.
J. Bagaitkar +8 more
semanticscholar +1 more source
Redox Biology, 2017 Recent clinical studies found a strong association of colonic inflammation and Inflammatory bowel disease (IBD)-like phenotype with NonAlcoholic Fatty liver Disease (NAFLD) yet the mechanisms remain unknown.
Varun Chandrashekaran +9 more
doaj +1 more source
Kinetics of proton pumping in cytochrome c oxidase [PDF]
J. Chem. Phys. 130, 235105 (2009), 2008 We propose a simple model of cytochrome c oxidase, including four redox centers and four protonable sites, to study the time evolution of electrostatically coupled electron and proton transfers initiated by the injection of a single electron into the enzyme.
arxiv +1 more source
NoxO1 Determines the Level of ROS Formation by the Nox1-Centered NADPH Oxidase. [PDF]
Antioxidants (Basel)The Nox1-centered NADPH oxidase complex facilitates the transfer of electrons from intracellular NADPH across the cell membrane to extracellular molecular oxygen, resulting in the formation of superoxide.
Hebchen DM +3 more
europepmc +2 more sources
Losartan metabolite EXP3179 blocks NADPH oxidase-mediated superoxide production by inhibiting protein kinase C: potential clinical implications in hypertension [PDF]
, 2009 Oxidative stress plays a critical role in the pathogenesis of hypertension. The NADPH oxidase constitutes a major source of superoxide anion in phagocytic cells, and its activation is associated with matrix metalloproteinase (MMP)-9 secretion by these ...
Beloqui, O. (Óscar) +7 more
core +1 more source
Mathematical Model for Chemical Reactions in Electrolyte Applied to Cytochrome $c$ Oxidase: an Electro-osmotic Approach [PDF]
arXiv, 2022 A mathematical model for chemical reactions in electrolytes is developed using an Energy variational method consistent with classical thermodynamics. Electrostatics and chemical reactions are included in properly defined energetic and dissipative functionals.
arxiv
Evolution of NADPH Oxidase Inhibitors: Selectivity and Mechanisms for Target Engagement.
Antioxidants and Redox Signaling, 2015 SIGNIFICANCE Oxidative stress, an excess of reactive oxygen species (ROS) production versus consumption, may be involved in the pathogenesis of different diseases.
Sebastian Altenhöfer +4 more
semanticscholar +1 more source