Results 101 to 110 of about 28,923 (304)

Effects of diet and antihyperglycemic drugs on erectile dysfunction: A systematic review

Andrology, Volume 11, Issue 2, Page 282-294, February 2023., 2023
Abstract Background Erectile dysfunction is recognized as one of the complications of diabetes mellitus. To date, a wide gap of knowledge is present on the efficacy of pharmacological treatments of diabetes mellitus on erectile function, acting not only through metabolic control. Similarly, the effects of different diet regimens on erectile dysfunction
Giuseppe Defeudis, Rossella Mazzilli, Alfonso Maria Di Tommaso, Virginia Zamponi, Francesco Carlomagno, Dario Tuccinardi, Mikiko Watanabe, Antongiulio Faggiano, Daniele Gianfrilli   +8 more
wiley   +1 more source

Defects in Nicotinamide-adenine Dinucleotide Phosphate Oxidase Genes NOX1 and DUOX2 in Very Early Onset Inflammatory Bowel DiseaseSummary

Cellular and Molecular Gastroenterology and Hepatology, 2015
Background & Aims: Defects in intestinal innate defense systems predispose patients to inflammatory bowel disease (IBD). Reactive oxygen species (ROS) generated by nicotinamide-adenine dinucleotide phosphate (NADPH) oxidases in the mucosal barrier ...
Patti Hayes, Sandeep Dhillon, Kim O’Neill, Cornelia Thoeni, Ken Y. Hui, Abdul Elkadri, Conghui H. Guo, Lidija Kovacic, Gabriella Aviello, Luis A. Alvarez, Anne M. Griffiths, Scott B. Snapper, Steven R. Brant, James H. Doroshow, Mark S. Silverberg, Inga Peter, Dermot P.B. McGovern, Judy Cho, John H. Brumell, Holm H. Uhlig, Billy Bourke, Aleixo M. Muise, Ulla G. Knaus   +22 more
doaj  

Engineering an Overflow‐Responsive Regulation System for Balancing Cellular Redox and Optimizing Microbial Production

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Escherichia coli accumulates acetate as a byproduct in fast growth aerobic conditions when using glucose as carbon source. This phenomenon, known as overflow metabolism, has negative impacts on cell growth and protein expression, also causes carbon loss during biosynthesis in most microbial production scenarios. In this study, we regarded the “
Jianli Zhang, Jian Wang, Tian Jiang, Xinyu Gong, Qi Gan, Yuxi Teng, Yusong Zou, Ainoor Anwar Dawadi, Yajun Yan   +8 more
wiley   +1 more source

Copper in cancer: friend or foe? Metabolism, dysregulation, and therapeutic opportunities

Cancer Communications, EarlyView.
Abstract Copper, one of the essential nutrients for the human body, acts as an electron relay in multiple pathways due to its redox properties. Both deficiencies and excesses of copper lead to cellular fragility. Therefore, it can manifest pro‐ and anti‐cancer properties in tumors. Therefore, it is crucial to clarify the copper activity within the cell.
Dan Shan, Jinling Song, Yuqing Ren, Yuyuan Zhang, Yuhao Ba, Peng Luo, Quan Cheng, Hui Xu, Siyuan Weng, Anning Zuo, Shutong Liu, Xinwei Han, Jinhai Deng, Zaoqu Liu   +13 more
wiley   +1 more source

Should the non‐canonical pathway of nitric oxide generation be targeted in hypertensive pregnancies?

British Journal of Pharmacology, EarlyView., 2023
Abstract Hypertension in pregnancy is prevalent, affecting around 10% of pregnancies worldwide, and significantly increases the risk of adverse outcomes for both mothers and their babies. Current treatment strategies for pregnant women with hypertension are limited, and new approaches for the management of hypertension in pregnancy are urgently needed.
Elizabeth C. Cottrell
wiley   +1 more source

Effect of ELF e.m. fields on metalloprotein redox-active sites [PDF]

arXiv, 2008
The peculiarity of the distribution and geometry of metallic ions in enzymes pushed us to set the hypothesis that metallic ions in active-site act like tiny antennas able to pick up very feeble e.m. signals. Enzymatic activity of Cu2+, Zn2+ Superoxide Dismutase (SOD1) and Fe2+ Xanthine Oxidase (XO) has been studied, following in vitro generation and ...
arxiv  

Recombinant Production and Characterization of Six Ene‐reductases from Penicillium steckii

ChemBioChem, EarlyView.
This study explores the catalytic potential of novel ene‐reductases (ERs) from Penicillium steckii, a fungal species known for valuable metabolites. Through the recombinant production and purification of six ERs, we identified diverse substrate profiles and moderate stability.
Pedro H. Damada, Henriette J. Rozeboom, Marco W. Fraaije   +2 more
wiley   +1 more source

Factor groups, semidirect product and quantum chemistry [PDF]

arXiv, 2013
In this paper we prove some general theorems about representations of finite groups arising from the inner semidirect product of groups. We show how these results can be used for standard applications of group theory in quantum chemistry through the orthogonality relations for the characters of irreducible representations.
arxiv  

The superoxide-generating NADPH oxidase of human neutrophils is electrogenic and associated with an H+ channel [PDF]

, 1987
L. M. Henderson, Joseph Chappell, Owen Jones   +2 more
openalex   +1 more source

Natural Compounds as Modulators of NADPH Oxidases [PDF]

Oxidative Medicine and Cellular Longevity, 2013
Reactive oxygen species (ROS) are cellular signals generated ubiquitously by all mammalian cells, but their relative unbalance triggers also diseases through intracellular damage to DNA, RNA, proteins, and lipids. NADPH oxidases (NOX) are the only known enzyme family with the sole function to produce ROS.
openaire   +2 more sources