Results 141 to 150 of about 25,108 (267)

Engineering the substrate specificity of galactose oxidase [PDF]

, 2013
Biocatalysis, the use of enzymes to catalyse the generation of specific chemicals, has a number of advantages including high specificity, lower energy requirements and greater sustainability over an equivalent chemical process.
Chappell, Lucy
core  

Molecular mechanisms of hypertension: role of Nox family NADPH oxidases

, 2009
PURPOSE OF REVIEW: Molecular mechanisms contributing to the pathoetiology of hypertension are complex, involving many interacting systems such as signaling through G protein-coupled receptors, the renin-angiotensin system, vascular inflammation and ...
Kennedy, C.R., Sedeek, M., Touyz, R.M., Hébert, R.L., Burns, K.D.   +4 more
core   +1 more source

Nrf2 regulates ROS production by mitochondria and NADPH oxidase.

, 2015
Nuclear factor (erythroid-derived 2) factor 2 (Nrf2) is a crucial transcription factor mediating protection against oxidants. Nrf2 is negatively regulated by cytoplasmic Kelch-like ECH associated protein 1 (Keap1) thereby providing inducible antioxidant ...
Dinkova-Kostova, AT, Holmström, Kira M., Stjepana Kovaca, Kovac, S, Plamena R. Angelovaa, Ying Zhangb, Andrey Y. Abramova, Abramov, Andrey Y., Angelova, PR, Zhang, Y, Abramov, AY, Angelova, Plamena R., Kovac, Stjepana, Zhang, Ying, Kira M. Holmströma, Holmström, KM, Dinkova-Kostova, Albena T.; id_orcid, Dinkova-Kostova, Albena T., Albena T   +18 more
core   +1 more source

Post‐Translational Modifications of Key Proteins in Hematologic Malignancies: Carcinogenic Mechanisms, Biomarker Potential, and New Therapeutic Strategies

iLABMED, EarlyView.
This article reviews the pivotal role of post‐translational modifications of proteins in the development and progression of hematologic malignancies, and explores their clinical translation potential as novel biomarkers and therapeutic targets. ABSTRACT Post‐translational modifications (PTMs) of proteins have emerged as critical regulators in the ...
Yuxuan Han, Chaowei Zhang, Weiyi Yao, Qing Hong, Xinyu Tang, Yanan Zhu, Na Chen   +6 more
wiley   +1 more source

Ageing and endothelium-mediated vascular dysfunction: the role of the NADPH oxidases. [PDF]

J Physiol, 2023
Kwon OS, Noh SG, Park SH, Andtbacka RHI, Hyngstrom JR, Richardson RS.   +5 more
europepmc   +1 more source

Vascular NADPH oxidases as drug targets for novel antioxidant strategies

, 2006
Reactive oxygen species (ROS) play important roles in the pathogenesis of cardiovascular disease. Surprisingly, large clinical trials have shown that ROS scavenging by antioxidant vitamins is ineffective or harmful. Therefore, prevention of ROS formation,
Harrison, David G., Guzik, Tomasz J.
core   +1 more source

The Endothelial CXCR Family in Vascular Health and Disease

iNew Medicine, EarlyView.
ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu, Yandi Wu, Suowen Xu, Yu Huang, Li Wang   +4 more
wiley   +1 more source

NOX family NADPH oxidases in mammals: Evolutionary conservation and isoform-defining sequences. [PDF]

Redox Biol, 2023
Nazari B, Jaquet V, Krause KH.
europepmc   +1 more source

NADPH oxidases in Eukaryotes: red algae provide new hints!

, 2006
The red macro-alga Chondrus crispus is known to produce superoxide radicals in response to cell-free extracts of its green algal pathogenic endophyte Acrochaete operculata. So far, no enzymes involved in this metabolism have been isolated from red algae.
Corre, Erwan, Tonon, Thierry, Boyen, Catherine, Herve, Cécile, Collen, Jonas   +4 more
core   +1 more source

NADPH oxidase of neutrophils

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1996
Henderson, Lydia M., Chappell, J.Brian
openaire   +2 more sources