Results 181 to 190 of about 28,923 (304)

Low‐Intensity Pulsed Ultrasound Treatment Selectively Stimulates Senescent Cells to Promote SASP Factors for Immune Cell Recruitment

open access: yesAging Cell, EarlyView.
The regulatory effects of low‐intensity pulsed ultrasound (LIPUS) stimulation in senescent cells are presented. LIPUS perturbs the membrane in senescent cells and induces intracellular reactive oxygen species via NOX4 expression. Consequently, secretion of senescence‐associated secretory phenotype, followed by migration of monocytes/macrophages and ...
HyeRan Gwak   +7 more
wiley   +1 more source

Post-translational processing of rac p21s is important both for their interaction with the GDP/GTP exchange proteins and for their activation of NADPH oxidase.

open access: hybrid, 1992
Seiji Ando   +9 more
openalex   +1 more source

The PC motif : a novel and evolutionarily conserved sequence involved in interaction between p40 phox and p67phox, SH3 domain‐containing cytosolic factors of the phagocyte NADPH oxidase [PDF]

open access: bronze, 1998
Rika Nakamura   +8 more
openalex   +1 more source

Unraveling Alveolar Fibroblast and Activated Myofibroblast Heterogeneity and Differentiation Trajectories During Lung Fibrosis Development and Resolution in Young and Old Mice

open access: yesAging Cell, EarlyView.
Model of LIF‐to‐aMYF reversible switch during fibrosis formation and resolution in old mice. The main contributors during fibrosis formation to Cthrc1+ aMYF are Acta2+ LIFhigh alveolar fibroblasts. During fibrosis resolution, Cthrc1+ aMYF differentiate back to the LIFhigh (please write "high" in superscript) alveolar fibroblasts cluster.
Arun Lingampally   +18 more
wiley   +1 more source

Downregulation of NAD Kinase Expression in β‐Cells Contributes to the Aging‐Associated Decline in Glucose‐Stimulated Insulin Secretion

open access: yesAging Cell, EarlyView.
Adequate NADK/NADK2 level is essential to the proper functioning of redox and folate cycles and the purine biosynthesis pathway, and as well as maintenance of GSIS response. During aging, diminished NADK/NADK2 expression alters the metabolic status quo, increasing AICAR production. The latter activates AMPK and suppresses GSIS.
Guan‐Jie Li   +6 more
wiley   +1 more source

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