Results 71 to 80 of about 48,906 (319)

Organic AIE Nanoradiosensitizer Potentiates X‐Ray Triggered Continuous Reactive Oxygen Species Generation for Potent Cancer Radioimmunotherapy

Advanced Materials, EarlyView.
Herein, a glutathione‐responsive system (named THN) is prepared for X‐ray‐triggered sustained ROS generation for efficient antitumor immunotherapy. The double‐promoting ROS generation of THN induced massive immunogenic cancer cell death and polarized M2 macrophages into the M1 phenotype for enhanced antitumor immunotherapy.
Qingyong Xu, Minmin Zhang, Qinqin Huang, Song Gao, Sitong Chu, Qi Li, Wanyao Chen, Xinglong Zhang, Tianfu Zhang, Ben Zhong Tang, Shipeng Ning   +10 more
wiley   +1 more source

Oxidative Stress Resulting From Helicobacter pylori Infection Contributes to Gastric Carcinogenesis. [PDF]

, 2017
Helicobacter pylori is a gram-negative, microaerophilic bacterium that infects the stomach and can lead to, among other disorders, the development of gastric cancer. The inability of the host to clear the infection results in a chronic inflammatory state
Butcher, Lindsay D, Crowe, Sheila E, den Hartog, Gerco, Ernst, Peter B   +3 more
core   +2 more sources

Detection of reactive oxygen species in isolated, perfused lungs by electron spin resonance spectroscopy

Respiratory Research, 2005
Background The sources and measurement of reactive oxygen species (ROS) in intact organs are largely unresolved. This may be related to methodological problems associated with the techniques currently employed for ROS detection.
Schudt Christian, Schermuly Ralph T, Ghofrani Hossein A, Schütte Hartwig, Schäfer Rolf U, Tiyerili Vedat, Fuchs Beate, Kuzkaya Nermin, Weissmann Norbert, Sydykov Akylbek, Egemnazarow Bakytbek, Seeger Werner, Grimminger Friedrich   +12 more
doaj   +1 more source

Integrating Visible‐Light Photocatalysis and Enzymes for the Stereoselective Synthesis of Alcohols and Amines

Advanced Synthesis &Catalysis, EarlyView.
The integration between visible‐light photocatalysis and biocatalysis has the potential to greatly improve modern organic synthesis by combining the production of valuable synthetic intermediates under mild photochemical conditions with the high degree of stereoselectivity reached by enzymes. The review collects the recent efforts in the photoenzymatic
Stefano Parisotto, Cristina Prandi
wiley   +1 more source

7-Keto-Cholesterol and Cholestan-3beta, 5alpha, 6beta-Triol Induce Eryptosis through Distinct Pathways Leading to NADPH Oxidase and Nitric Oxide Synthase Activation [PDF]

, 2019
BACKGROUND/AIMS: We showed that patho-physiological concentrations of either 7-keto-cholesterol (7-KC), or cholestane-3beta, 5alpha, 6beta-triol (TRIOL) caused the eryptotic death of human red blood cells (RBC), strictly dependent on the early production
Allegra M., Attanzio A., Cilla A., Frazzitta A., Livrea M. A., Tesoriere L.   +5 more
core   +1 more source

Ragweed subpollen particles of respirable size activate human dendritic cells [PDF]

, 2017
Ragweed (Ambrosia artemisiifolia) pollen grains, which are generally considered too large to reach the lower respiratory tract, release subpollen particles (SPPs) of respirable size upon hydration.
Boldogh, István, Bácsi, Attila, Kumar, Brahma V., Lányi, Árpád, Pázmándi, Kitti Linda, Rajnavölgyi, Éva, Szabó, Krisztina, Szöőr, Árpád, Vereb, György, Veres, Ágota   +9 more
core   +3 more sources

NAMPT-derived NAD+ fuels PARP1 to promote skin inflammation through parthanatos cell death.

PLoS Biology, 2021
Several studies have revealed a correlation between chronic inflammation and nicotinamide adenine dinucleotide (NAD+) metabolism, but the precise mechanism involved is unknown.
Francisco J Martínez-Morcillo, Joaquín Cantón-Sandoval, Francisco J Martínez-Navarro, Isabel Cabas, Idoya Martínez-Vicente, Joy Armistead, Julia Hatzold, Azucena López-Muñoz, Teresa Martínez-Menchón, Raúl Corbalán-Vélez, Jesús Lacal, Matthias Hammerschmidt, José C García-Borrón, Alfonsa García-Ayala, María L Cayuela, Ana B Pérez-Oliva, Diana García-Moreno, Victoriano Mulero   +17 more
doaj   +1 more source

NOX2 Contributes to High‐Frequency Outer Hair Cell Vulnerability in the Cochlea

Advanced Science, EarlyView.
This study first identifies NOX2 as a differentially expressed gene related to oxidative damage in the apical and basal turns through single‐cell RNA sequencing. NOX2 gene knockout mitigates OHCs damage caused by neomycin and noise and enhances Nrf2 expression and nuclear translocation.
Meihao Qi, Zejun Gao, Yang Qiu, Renfeng Wang, Keyong Tian, Bo Yue, Xinyu Zhang, Peng Zhang, Ziqi Wu, Qingwen Zhu, Zhenzhen Liu, Zhuoyao Ma, Xueying Zhou, Yu Han, Jun Chen, Jianhua Qiu, DingJun Zha   +16 more
wiley   +1 more source

Regulation of reactive oxygen species during plant immunity through phosphorylation and ubiquitination of RBOHD. [PDF]

, 2020
Production of reactive oxygen species (ROS) is critical for successful activation of immune responses against pathogen infection. The plant NADPH oxidase RBOHD is a primary player in ROS production during innate immunity. However, how RBOHD is negatively
Castro, Bardo, Coaker, Gitta, Dinesh-Kumar, Savithramma P, Lal, Neeraj K, Lee, DongHyuk, Lin, Zuh-Jyh Daniel, Liu, Jun, Ma, Shisong, Toruño, Tania   +8 more
core   +1 more source

Diabetic Cardiovascular Disease Induced by Oxidative Stress. [PDF]

, 2015
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality among patients with diabetes mellitus (DM). DM can lead to multiple cardiovascular complications, including coronary artery disease (CAD), cardiac hypertrophy, and heart failure
Adam, Matti, Jagger, Ann, Kayama, Yosuke, Raaz, Uwe, Sakamoto, Masaya, Schellinger, Isabel N, Spin, Joshua M, Suzuki, Hirofumi, Toyama, Kensuke, Tsao, Philip S   +9 more
core   +2 more sources