Results 71 to 80 of about 296,542 (336)

Development of Photo‐Biocatalytic Redox System for Asymmetric Synthesis of Optically Active Amines Using Blue Light and Transaminases. A Case Study Toward Mavacamten

Advanced Synthesis &Catalysis, EarlyView.
Abstract α‐Chiral amines are versatile building blocks for the asymmetric synthesis of optically pure high‐added‐value chemicals, including pharmaceuticals, agrochemicals, and natural products. Herein, we report a one‐pot, two‐step sequential deracemization of racemic sec‐alcohols to optically enriched primary amines throught a photo‐biocatalytic ...
Natalia Antos, Aleksandra Rudzka, Anna Hoser, Tamara Reiter, Wolfgang Kroutil, Paweł Borowiecki   +5 more
wiley   +1 more source

NADPH Oxidases, Angiogenesis, and Peripheral Artery Disease

Antioxidants, 2017
Peripheral artery disease (PAD) is caused by narrowing of arteries in the limbs, normally occurring in the lower extremities, with severe cases resulting in amputation of the foot or leg.
Pradeep Manuneedhi Cholan, Siân P. Cartland, Mary M. Kavurma   +2 more
doaj   +1 more source

Distinction between 2′- and 3′-Phosphate Isomers of a Fluorescent NADPH Analogue Led to Strong Inhibition of Cancer Cells Migration

Antioxidants, 2021
Specific inhibition of NADPH oxidases (NOX) and NO-synthases (NOS), two enzymes associated with redox stress in tumor cells, has aroused great pharmacological interest.
Raoul Manuel, Michelle de Souza Lima, Sébastien Dilly, Sylvain Daunay, Patricia Abbe, Elodie Pramil, Stéphanie Solier, Fabienne Guillaumond, Sarah-Simha Tubiana, Alexandre Escargueil, João Antonio Pêgas Henriques, Nathalie Ferrand, Irène Erdelmeier, Jean-Luc Boucher, Gildas Bertho, Israel Agranat, Stéphane Rocchi, Michèle Sabbah, Anny Slama Schwok   +18 more
doaj   +1 more source

Reaction of the desulfoferrodoxin from Desulfoarculus baarsii with superoxide anion. Evidence for a superoxide reductase activity [PDF]

The journal of biological chemistry, American Society for Biochemistry and Molecular Biology, 2000, 275, pp.115-21, 2014
Desulfoferrodoxin is a small protein found in sulfate-reducing bacteria that contains two independent mononuclear iron centers, one ferric and one ferrous. Expression of desulfoferrodoxin from Desulfoarculus baarsii has been reported to functionally complement a superoxide dismutase deficient Escherichia coli strain.
arxiv   +1 more source

The interplay of reactive oxygen species, hypoxia, inflammation, and sirtuins in cancer initiation and progression [PDF]

, 2016
The presence of ROS is a constant feature in living cells metabolizing O2. ROS concentration and compartmentation determine their physiological or pathological effects.
ARCANGELI, TANIA, DE SANTIS, Elena, LIMANA, FEDERICA, Massimo, Fini, Matteo, A. Russo3, POLESE, MILENA, SANSONE, LUIGI, TAFANI, MARCO   +7 more
core   +1 more source

A 3D‐Printed Microfluidic Sensor Platform for Online Bioprocess Monitoring

Advanced Sensor Research, EarlyView.
A 3D‐printed microfluidic lab‐on‐a‐chip sensor platform is presented, compatible with various cultivation setups, that integrates sensors for pH, pO₂, pCO₂, glucose, lactate, and additionally features a sampling unit for small‐volume abstraction. With this platform, continuous real‐time monitoring of critical bioprocess parameters is enabled and ...
Christopher Heuer, Anton Enders, Steffen Winkler, Martin Klaßen, Thorsten Teutenberg, Janina Bahnemann   +5 more
wiley   +1 more source

Functional Interplay Between Arabidopsis NADPH Oxidases and Heterotrimeric G Protein

Molecular Plant-Microbe Interactions, 2013
The plant NADPH oxidases produce reactive oxygen species (ROS) in response to pathogens that have diverse functions in different cellular contexts. Distinct phenotypic outcomes may derive from the interaction of NADPH oxidase-dependent ROS with other ...
Miguel Angel Torres, Jorge Morales, Clara Sánchez-Rodríguez, Antonio Molina, Jeffery L. Dangl   +4 more
doaj   +1 more source

Counteraction of HCV-induced oxidative stress concurs to establish chronic infection in liver cell cultures [PDF]

, 2019
Hepatitis C virus (HCV) is a blood-borne pathogen causing acute and chronic hepatitis. A significant number of people chronically infected with HCV develop cirrhosis and/or liver cancer.
Amatore, Donatella, Anticoli, Simona, DE ANGELIS, Marta, Matarrese, Paola, Nencioni, Lucia, Palamara, ANNA TERESA, Ruggieri, Anna   +6 more
core   +1 more source

Recent Advancements in Lung Cancer Metastasis Prevention Based on Nanostrategies

Advanced Science, EarlyView.
Metastasis is the leading cause of death in patients with lung cancer. Nanomedicine can be used to prepare efficient drug delivery systems owing to their advantages and plays an important role in the synergistic antimetastasis of lung cancer. This comprehensive review summarizes the emerging nanostrategies against lung cancer metastasis based on the ...
Fan Xu, Yao Liu, Zujun Que, Bin Luo, Yun Yang, Yan Li, Zhanxia Zhang, Jianhui Tian   +7 more
wiley   +1 more source

Mitochondrial regulation of NADPH oxidase in hindlimb unweighting rat cerebral arteries.

PLoS ONE, 2014
Exposure to microgravity results in post-flight cardiovascular deconditioning and orthostatic intolerance in astronauts. Vascular oxidative stress injury and mitochondrial dysfunction have been indicated in this process.
Ran Zhang, Hai-hong Ran, Liang Peng, Fei Xu, Jun-fang Sun, Lan-ning Zhang, Yong-yan Fan, Li Peng, Geng Cui   +8 more
doaj   +1 more source