Results 71 to 80 of about 176,389 (357)

Health disparities in chronic liver disease

Hepatology, EarlyView., 2022
Abstract The syndemic of hazardous alcohol consumption, opioid use, and obesity has led to important changes in liver disease epidemiology that have exacerbated health disparities. Health disparities occur when plausibly avoidable health differences are experienced by socially disadvantaged populations.
Ani Kardashian, Marina Serper, Norah Terrault, Lauren D. Nephew   +3 more
wiley   +1 more source

RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease

Hepatology, EarlyView., 2022
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso, Tawhidul Islam, Julie Magusto, Ricardo Amorim, Véronique Lenoir, Rui F. Simões, José Teixeira, Liana C. Silva, Dominique Wendum, Isabelle Jéru, Corinne Vigouroux, Rui E. Castro, Paulo J. Oliveira, Carina Prip‐Buus, Vlad Ratziu, Jérémie Gautheron, Cecília M. P. Rodrigues   +16 more
wiley   +1 more source

Nicotinamide riboside and pterostilbene reduces markers of hepatic inflammation in NAFLD: A double‐blind, placebo‐controlled clinical trial

Hepatology, EarlyView., 2022
NRPT 1X reduces ALT and ceramide 14:0 in 65% of subjects as compared to only 28% in the placebo group. Abstract Background and Aims The prevalence of NAFLD is increasing globally and on a path to becoming the most frequent cause of chronic liver disease. Strategies for the prevention and treatment of NAFLD are urgently needed.
Ryan W. Dellinger, Holly E. Holmes, Tina Hu‐Seliger, Rodney W. Butt, Stephen A. Harrison, Dariush Mozaffarian, Oliver Chen, Leonard Guarente   +7 more
wiley   +1 more source

Healthcare and Socioeconomic Costs of NAFLD: a Global Framework to Navigate the Uncertainties

Journal of Hepatology, 2023
Left unaddressed, NAFLD will continue to have substantial health, economic and social implications. To address the challenge, a paradigm shift is needed in the way NAFLD is conceptualised.
A. Allen, J. Lazarus, Z. Younossi
semanticscholar   +1 more source

Evaluation of peripheral serotonergic activation for the treatment of NAFLD

, 2023
reservedLa steatosi epatica non alcolica o NAFLD, caratterizzata da un eccessivo accumulo di lipidi nel fegato, è considerata una condizione benigna reversibile; ha una prevalenza del 20-30% nei paesi occidentali, 30-50% nei pazienti con diabete mellito
CADORE, ALESSANDRO
core  

c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis

Hepatology, EarlyView., 2022
In response to genotoxic injury, c‐Rel upregulates ATM‐Chk2‐p53 pathway DNA damage proteins to limiting hepatocarcinogenesis. Abstract Background and Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death. The NF‐κB transcription factor family subunit c‐Rel is typically protumorigenic; however, it has recently been reported as a
Jack Leslie, Jill E. Hunter, Amy Collins, Amelia Rushton, Lauren G. Russell, Erik Ramon‐Gil, Maja Laszczewska, Misti McCain, Marco Y. W. Zaki, Amber Knox, Yixin Seow, Laura Sabater, Daniel Geh, Neil D. Perkins, Helen L. Reeves, Dina Tiniakos, Derek A. Mann, Fiona Oakley   +17 more
wiley   +1 more source

Hepatoprotective properties of Gentiana SPP: Against non-alcoholic fatty liver disease (NAFLD) [PDF]

, 2018
Non-alcoholic fatty liver disease (NAFLD) is a metabolic disease characterised by the accumulation of fat in the liver. It is estimated that 33 % of the UK population have NAFLD with 2-5 % progressing to non-alcoholic steatohepatitis (NASH).
Boateng, A.
core   +1 more source

Protocols for Mitochondria as the Target of Pharmacological Therapy in the Context of Nonalcoholic Fatty Liver Disease (NAFLD).

, 2021
Nonalcoholic fatty liver disease (NAFLD) is one of the most frequent metabolic chronic liver diseases in developed countries and puts the populations at risk of progression to liver necroinflammation, fibrosis, cirrhosis, and hepatocellular ...
Grattagliano I, Molina-Molina E, Shanmugam H, Garruti G, Di Ciaula A, Baj J, Wang DQ, Portincasa P   +7 more
core   +1 more source

A PDCD1 Role in the Genetic Predisposition to NAFLD-HCC? [PDF]

, 2021
Obesity and non-alcoholic fatty liver disease (NAFLD) are contributing to the global rise in deaths from hepatocellular carcinoma (HCC). The pathogenesis of NAFLD-HCC is not well understood. The severity of hepatic steatosis, steatohepatitis and fibrosis
Burt, Alastair D, Yang Lin Liu, Misti Vanette McCain, João P. Maurício, Ruchi Shukla, Marco Y. W. Zaki, Ann K. Daly, Fawzy, Michael Atef, Moustafa Fathy, Quentin M. Anstee, Nardeen Eldafashi, Burt, Alastair D., Cristiana Bianco, Cordell, Heather J, Darlay, Rebecca, McCain, Misti Vanette, Shukla, Ruchi, Daly, Ann K, Fathy, Moustafa, Bianco, Cristiana, Rebecca Darlay, Jean-François Dufour, Anstee, Quentin M, Reeves, Helen L, Anstee, Quentin M., Helen L. Reeves, Zaki, Marco Y. W., Dufour, Jean-François, Heather J. Cordell, Haugk, Beate, Maurício, João P, Michael Atef Fawzy, Zaki, Marco Y W, Daly, Ann K., Alastair D. Burt, Maurício, João P., Beate Haugk, Liu, Yang Lin, Reeves, Helen L., Watson, Robyn, Valenti, Luca, Luca Valenti, McStraw, Nikki, Eldafashi, Nardeen, Cordell, Heather J., Robyn Watson, Nikki McStraw   +46 more
core   +2 more sources

CD11b+CD43hiLy6Clo splenocyte‐derived macrophages exacerbate liver fibrosis via spleen–liver axis

Hepatology, EarlyView., 2022
A population of splenic monocytes migrate into the liver and shift to macrophages, which account for the exacerbation of liver fibrosis. Abstract Background and Aims Monocyte‐derived macrophages (MoMFs), a dominant population of hepatic macrophages under inflammation, play a crucial role in liver fibrosis progression.
Shaoying Zhang, Dan Wan, Mengchen Zhu, Guihu Wang, Xurui Zhang, Na Huang, Jian Zhang, Chongyu Zhang, Qi Shang, Chen Zhang, Xi Liu, Fanfan Liang, Chunyan Zhang, Guangyao Kong, Jing Geng, Libo Yao, Shemin Lu, Yongyan Chen, Zongfang Li   +18 more
wiley   +1 more source