Results 91 to 100 of about 147,468 (308)

The Role of Extracellular Vesicles MicroRNAs in Sarcopenia: From Aging to Multi‐Morbidity

AGING MEDICINE, EarlyView.
Exosomes transporting miRNAs play a crucial bidirectional regulatory role in the process of sarcopenia, both in natural aging and under various pathological conditions. ABSTRACT Sarcopenia, defined as progressive loss of skeletal muscle mass and function, occurs during aging and has also been recognized for its detrimental effects in various disease ...
Bingyu Huang, Zhao Peng, Lin Kang
wiley   +1 more source

ZNF143 inhibits hepatocyte mitophagy and promotes non-alcoholic fatty liver disease by targeting increased lncRNA NEAT1 expression to activate ROCK2 pathway

Epigenetics, 2023
Background: Nonalcoholic fatty liver disease (NAFLD) is the most common hepatic disorders worldwide. The mitophagy is suggested to be repressed in NAFLD, but the mechanism remains to be elucidated. Methods: NAFLD cell and mouse models were established by
Yujie Dong, Minjie Hu, Kewei Tan, Rongjuan Dai   +3 more
doaj   +1 more source

Non-alcoholic fatty liver disease in Asian Indian adolescents and young adults: Prevalence and its associated risk factors

Journal of Diabetology, 2021
Background: Non-alcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease in the youth. The aim of the study was to conduct a metabolic risk factor profiling of NAFLD in adolescents and young adults in Chennai city in south ...
Thaharullah Shah Mehreen, Ranjani Harish, Rajan Kamalesh, Ranjit Mohan Anjana, Viswanathan Mohan   +4 more
doaj   +1 more source

Vitamin E as a Treatment for Nonalcoholic Fatty Liver Disease: Reality or Myth? [PDF]

, 2018
Obesity is one of the major epidemics of this millennium, and its incidence is growing worldwide. Following the epidemics of obesity, nonalcoholic fatty liver disease (NAFLD) has become a disease of increasing prevalence and a leading cause of morbidity ...
El Hadi, Hamza, Rossato, Marco, Vettor, Roberto   +2 more
core   +2 more sources

Mapping quantitative trait loci underlying body weight changes that act at different times during high‐fat diet challenge in collaborative cross mice

Animal Models and Experimental Medicine, EarlyView.
Over one billion people worldwide suffer from obesity, and the number is continually rising. Animal models, especially mouse models, are crucial to identifying the genetic components of complex disorders and exploring the potential applications of these genetic findings.
Hanifa J. Abu‐Toamih Atamni, Iqbal M. Lone, Ilona Binenbaum, Kareem Midlej, Eleftherios Pilalis, Richard Mott, Aristotelis Chatziioannou, Fuad A. Iraqi   +7 more
wiley   +1 more source

The effect of low volume sprint interval training in patients with non-alcoholic fatty liver disease [PDF]

, 2017
Objectives: Exercise is an important part of disease management in patients with non-alcoholic fatty liver disease (NAFLD), but adherence to current exercise recommendations is poor.
Babraj, John A., Dillon, John, MacLean, Catriona, Vollaard, Niels B. J.   +3 more
core   +5 more sources

Sex as a biological variable in nonclinical studies: Bridging scientific rigor, animal welfare, and regulatory expectations

Animal Models and Experimental Medicine, EarlyView.
Sex as a biological variable (SABV) is a critical determinant of pharmacokinetics, pharmacodynamics, and toxicity in nonclinical studies. This review highlights how inappropriate neglect of sex differences compromises animal welfare, scientific reproducibility, and regulatory compliance.
Kenta Onuma, Masaki Watanabe, Nobuya Sasaki   +2 more
wiley   +1 more source

Body composition and body fat distribution are related to cardiac autonomic control in non-alcoholic fatty liver disease patients [PDF]

, 2013
BACKGROUND/OBJECTIVES: Heart rate recovery (HRR), a cardiac autonomic control marker, was shown to be related to body composition (BC), yet this was not tested in non-alcoholic fatty liver disease (NAFLD) patients.
B Fernhall, C Panzer, CR Cole, DD Christou, DM Hadley, DP Vivekananthan, E Bertin, E Savgan-Gurol, EG Kamel, EO Nishime, ET Howley, F Kreier, G Nilsson, G Targher, GA Bray, H Cortez-Pinto, H Cortez-Pinto, H Nomura, H Santa-Clara, IJ Ketel, J Cohen, J Myers, J Silva-Nunes, JD Browning, JF Horowitz, JM Clark, K Imai, K Shetler, KM Chacko, L B Sardinha, LA Diaz, LR Davrath, M Cote, M da Lapa Rosado, M Gnacinska, M Lafontan, MA Kizilbash, MB Snijder, MJ Lipinski, MK Kim, MR Carnethon, MR Carnethon, MR Esco, MS Chen, N M Pimenta, NM Pimenta, P Angulo, P J Sousa, R Arena, R Calé, RA Bruce, RS Rector, S Bellentani, TA Hargens, TG Lohman, TJ Bartness, X Melo, YJ Cheng, YW Park   +58 more
core   +1 more source

Hepatotoxicity of Nonesterified Fatty Acids to Dairy Cows: Pathophysiological Mechanisms and Prospective Solutions

Animal Research and One Health, EarlyView.
Unregulated inflammation increases non‐esterified fatty acids (NEFAs), and triggers multi‐pathway hepatocyte damage including oxidative stress, mitochondrial dysfunction, and metabolic disorders in dairy cows. ABSTRACT Circulating concentrations of nonesterified fatty acids (NEFAs) are elevated due to lipid mobilization from adipose tissue in ...
Siqing Mao, Yuan Tian, Dan Li, Lei Tian, Hang Yu, Ziling Liu, Xin Gao, Yanqiong Wen, Fachun Wan, Zuo Wang, Weijun Shen, Xinwei Li, Lei Liu   +12 more
wiley   +1 more source

Association Between High Sensitivity Cardiac Troponin and All-Cause and Cardiovascular Mortality in Adults at Risk of Non-Alcoholic Fatty Liver Disease: A Cohort Study

Global Heart
Objective: Cardiovascular disease (CVD) is the leading cause of death among patients with non-alcoholic fatty liver disease (NAFLD). This study investigates the association between high-sensitivity cardiac troponin (hs-cTn) levels and mortality in adults
Enfa Zhao, Hang Xie, Yuan Gao, Xiaolin Wen, Bingtian Dong, Chaoxue Zhang   +5 more
doaj   +1 more source