Results 101 to 110 of about 176,389 (357)

Association between PPARGC1A polymorphisms and the occurrence of nonalcoholic fatty liver disease (NAFLD)-0

, 2011
pair of SNPs and are shown as the strand of the LD blocks. The minor allele frequencies of all SNPs used in this analysis were >20%. Each SNP is labeled with its rs number.Copyright information:Taken from "Association between PPARGC1A polymorphisms and ...
Hironori Mawatari (94243), Kunihiro Hosono (94246), Hirokazu Takahashi (94249), Shiro Maeyama (94256), Shingo Kato (94245), Noritoshi Kobayashi (94251), Yuichi Nozaki (94240), Masahiko Inamori (94252), Yasunobu Abe (94253), Kikuko Hotta (94239), Hiroshi Iida (94244), Kyoko Yoneda (94248), Hiroki Endo (94241), Takashi Uchiyama (94242), Koichiro Wada (94257), Masato Yoneda (94238), Kensuke Kubota (94254), Koji Fujita (94247), Satoru Saito (94255), Atsushi Nakajima (94258), Hiroyuki Kirikoshi (94250)   +20 more
core   +1 more source

Ahcy Acts as an Effector of Hnf4a‐Driven Super‐Enhancer Activation to Alleviate MASLD During Intermittent Fasting

Advanced Science, EarlyView.
Our study identifies an Hnf4a‐driven super‐enhancer of hepatic Ahcy that mediates the protective effects of intermittent fasting against MASLD. Disruption of the Ahcy super‐enhancer reduces Ahcy expression and exacerbates lipid accumulation. This pathway prevents aberrant promoter hypermethylation by maintaining the SAM/SAH balance, as exemplified by ...
Huafeng Chen, Shilin Zhang, Xiaojie Deng, Wenqiang Xie, Fen Xu, Jie Shen, Hua Liang   +6 more
wiley   +1 more source

TGF Beta as a Prognostic Biomarker of COVID-19 Severity in Patients with NAFLD—A Prospective Case–Control Study

, 2023
Non-alcoholic fatty liver disease (NAFLD), the leading cause of chronic liver disease in Western countries, has been identified as a possible risk factor for COVID-19 severity.
Vince, Adriana, Vrsaljko, Nina, Frano Susak, Adriana Vince, Neven Papic, Šušak, Frano, Papić, Neven, Nina Vrsaljko   +7 more
core   +1 more source

OAF Blocks SIAH1‐Mediated Degradation of SCPX, a Therapeutic Strategy for MASLD

Advanced Science, EarlyView.
This study shows OAF directly binds to SCPX and inhibits its interaction with the E3 ligase SIAH1, thereby protecting SCPX from ubiquitin‐dependent degradation and stabilizing its levels. This OAF‐SCPX axis represents a novel pathway in lipid homeostasis, highlighting OAF as a promising therapeutic candidate for MASLD.
Zongxi Li, Jingyue Song, Kaili Ma, Shunan Tang, Shuqian Wang, Wenya Ji, Chen Lu, Ting Zhang, Huaping Zheng, Xiaowei Zheng, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source

GSDMD induces hepatocyte pyroptosis to trigger alcoholic hepatitis through modulating mitochondrial dysfunction

Cell Division
Background Mechanisms and consequences of Gasdermin D (GSDMD) activation in alcoholic hepatitis (AH) are unclear. In the present study, we investigated whether GSDMD induces hepatocyte pyroptosis by regulating mitochondrial dysfunction in AH.
Yandi Xie, Zilong Wang, Guangjun Song, Hui Ma, Bo Feng   +4 more
doaj   +1 more source

High-dose vitamin B1 therapy prevents the development of experimental fatty liver driven by overnutrition

Disease Models & Mechanisms, 2021
Fatty liver is an abnormal metabolic condition of excess intrahepatic fat. This condition, referred to as hepatic steatosis, is tightly associated with chronic liver disease and systemic metabolic morbidity. The most prevalent form in humans, i.e.
Mugagga Kalyesubula, Ramgopal Mopuri, Jimmy Asiku, Alexander Rosov, Sara Yosefi, Nir Edery, Samuel Bocobza, Uzi Moallem, Hay Dvir   +8 more
doaj   +1 more source

Leveraging Microphysiological Systems to Facilitate Neutrophil‐Based Cancer Immunotherapy

Advanced Science, EarlyView.
Microphysiological systems are emerging as powerful human‐relevant platforms for studying neutrophil biology in cancer. Current applications of spheroids, organoids, and organ‐on‐a‐chip models are reviewed, together with future opportunities in behaviorome profiling, multi‐omics integration, personalized medicine, immune crosstalk, and multi‐organ ...
Shuai Shao, Markus Isfeld Diehl, Caroline N. Jones   +2 more
wiley   +1 more source

The role of intestinal disbiosis in the development of mitochondrial dysfunction and nonalcoholic fatty liver disease

Медицинский совет, 2018
Taking into account the numerous metabolic functions of microflora, violation of its colonization resistance is considered as a trigger factor in the development of a number of different diseases.
P. V. Seliverstov, S. I. Sitkin, V, G. Radchenko   +2 more
doaj   +1 more source

The Intricate Relationship between Type 2 Diabetes Mellitus (T2DM), Insulin Resistance (IR), and Nonalcoholic Fatty Liver Disease (NAFLD)

Journal of Diabetes Research, 2020
Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) remain as one of the most global problematic metabolic diseases with rapidly increasing prevalence and incidence.
D. Tănase, E. Gosav, C. Costea, M. Ciocoiu, C. Lacatusu, M. Mărănducă, A. Ouatu, M. Floria   +7 more
semanticscholar   +1 more source

NAFLD and cardiovascular disease

Porto Biomedical Journal, 2018
Abstract Nonalcoholic fatty liver disease (NAFLD) is an important cause of chronic hepatic disease and liver transplant in Western societies. The increasing prevalence is related to dietary changes and sedentarism and follows the increasing frequency of obesity and type 2 diabetes mellitus.
Martins, Elisabete, Oliveira, Ana
openaire   +3 more sources