Results 41 to 50 of about 1,762 (164)

Clinical Associations of Anti‐RNPC3 Autoantibodies in Mixed Connective Tissue Disease

ACR Open Rheumatology, Volume 8, Issue 4, April 2026.
Objective The RNA‐binding region‐containing protein 3 (RNPC3) protein acts as a molecular bridge, promoting U11/U12 RNP complex formation. In previous reports, patients with systemic sclerosis (SSc) with anti‐RNPC3 autoantibodies had an increased risk of interstitial lung disease (ILD), severe gastrointestinal (GI) disease, and cancer.
Darya S. Jalaledin, Hajar El Kamouni, Alexandra Albert, Sabrina Hoa, Josiane Bourré‐Tessier, Eric Rich, Jean‐Richard Goulet, Martial Koenig, Gemma Pérez, May Y. Choi, Yves Troyanov, Minoru Satoh, Marvin J. Fritzler, Jean‐Luc Senécal, Océane Landon‐Cardinal   +14 more
wiley   +1 more source

Capillaroscopy as a diagnostic tool in the diagnosis of mixed connective tissue disease (MCTD): a case report

BMC Rheumatology, 2021
Background The concept of mixed connective tissue disease (MCTD) as a unique connective tissue disease has endured for half a century. Disease onset can be in adulthood (MCTD) or of juvenile onset (jMCTD) and is characterized by overlapping features of ...
Mislav Radić, Rebecca S. Overbury
doaj   +1 more source

Distinct by Design: Unraveling the Unique Clinical and Transcriptomic Identity of Juvenile Scleromyositis Overlap Compared to Juvenile Systemic Sclerosis and Juvenile Dermatomyositis: Implications for Care and Pathogenesis

ACR Open Rheumatology, Volume 8, Issue 3, March 2026.
Objective To characterize clinical and transcriptomic differences in juvenile scleromyositis overlap (jOverlap) compared to juvenile systemic sclerosis (jSSc) and juvenile dermatomyositis (JDM), focusing on autoantibody profiles, organ involvement, treatment, and peripheral blood gene expression.
Amanda D. Robinson, Clare E. Pain, Gabrielle A. Morgan, Anwesha Sanyal, Srilakshmi Chaparala, Lauren M. Pachman, Kathryn S. Torok   +6 more
wiley   +1 more source

Fractal Anatomy of Human Organs: A Narrative Review of Structure, Function, and Clinical Perspectives

Clinical Anatomy, Volume 39, Issue 2, Page 273-280, March 2026.
ABSTRACT Fractal geometry describes complex, self‐similar patterns that repeat across spatial scales and is increasingly recognized as relevant in anatomical research. Indeed, the fractal organization is consistently observed in respiratory, cardiovascular, gastrointestinal, nervous, renal, hepatic, and dermatological systems.
Immacolata Belviso, Jacopo Junio Valerio Branca, Giulia Guarnieri, Annamaria Morelli, Alessandra Pacini, Daniele Della Posta, Domenico Ribatti, Ferdinando Paternostro   +7 more
wiley   +1 more source

Nailfold capillaroscopy in the rheumatological current clinical practice in Italy: results of a national survey

Reumatismo, 2022
This cross-sectional online study was designed by the study group on Capillaroscopy and Microcirculation in Rheumatic Diseases (CAP) of the Italian Society of Rheumatology (SIR) to provide an overview of the management of nailfold capillaroscopy in ...
F. Ingegnoli, M. Cornalba, R. De Angelis, S. Guiducci, D. Giuggioli, C. Pizzorni, V. Riccieri, M. Sebastiani, A. Sulli, M. Cutolo   +9 more
doaj   +1 more source

Cardiac disease in systemic sclerosis: Integrating pathobiology with clinical management

Rheumatology &Autoimmunity, Volume 6, Issue 1, Page 16-38, March 2026.
Abstract Systemic sclerosis (SSc) is a complex autoimmune disorder in which cardiovascular involvement remains a major determinant of morbidity and mortality. Cardiac injury in SSc results from the interplay of microvascular dysfunction, immune‐mediated inflammation, and progressive interstitial and replacement fibrosis, leading to myocardial disease ...
Henry Sutanto, Betty Rachma, Yuliasih
wiley   +1 more source

Clinical profiles associated with rapidly progressive interstitial lung disease in antisynthetase syndrome: A multicentric cohort study (TYPASS study)

Journal of Internal Medicine, Volume 299, Issue 3, Page 365-380, March 2026.
Abstract Objectives To assess factors associated with rapidly progressive interstitial lung disease (ILD) (RP‐ILD) at time of ILD diagnosis in a multicentric retrospective cohort study of antisynthetase syndrome (ASyS). We used a complementary unsupervised approach, hierarchical clustering, to delineate distinct phenotypes among ASyS patients with ILD.
Maxime Billotte, Thomas Moulinet, Alain Meyer, Houda Camara, Loïs Bolko, Kévin Didier, Sandra Dury, Bernard Bonnotte, Hervé Devilliers, Philippe Bonniaud, Guillaume Beltramo, Julien Campagne, Nadine Magy‐Bertrand, Aurore Chaudier, Simon Valentin, Roland Jaussaud, Paul Decker   +16 more
wiley   +1 more source

Capillaroscopy – a role in modern rheumatology

Rheumatology, 2016
Capillaroscopy is a non-invasive, easy and safe diagnostic technique designed to evaluate small vessels of the microcirculation in the nailfold. It can reveal both the general architecture of capillary rows and fine details of particular vessels.
Marek M. Chojnowski, Anna Felis-Giemza, Marzena Olesińska   +2 more
doaj   +1 more source

Clinical Characteristics and Evolution of Interstitial Lung Disease in Subtypes of Idiopathic Inflammatory Myositis With Prevalent Lung Manifestation: A Retrospective Analysis

ACR Open Rheumatology, Volume 8, Issue 2, February 2026.
Objective Interstitial lung disease (ILD) is common in idiopathic inflammatory myositis (IIM), particularly in antisynthetase syndrome (ASyS), antimelanoma differentiation‐associated protein 5 (anti‐MDA5) syndrome, and scleromyositis. ILD can progress despite resolution of extrapulmonary symptoms, termed postmyopathic progressive pulmonary fibrosis ...
Julia Clark, Dora Chan, Damon Dhillon, Jan Dutz, Gillian Goobie, Kun Huang   +5 more
wiley   +1 more source

Ausência de correlação entre as alterações morfológicas e bioquímicas na microcirculação de pacientes com esclerose sistêmica Absence of correlation between morphological and biochemical alterations in the microcirculation of patients with systemic sclerosis

Revista Brasileira de Reumatologia, 2004
OBJETIVO: A medida da lacticemia de polpa digital sob estímulo frio (LPD-EF) avalia um componente bioquímico da microcirculação, apresentando resultados anormais na esclerose sistêmica (ES).
Cristiane Kayser, Luís Eduardo Coelho Andrade   +1 more
doaj   +1 more source