Bivalent and bitopic ligands of the opioid receptors: The prospects of a dual approach
Medicinal Research Reviews, Volume 44, Issue 6, Page 2545-2599, November 2024.Abstract Opioid receptors belonging to the class A G‐protein coupled receptors (GPCRs) are the targets of choice in the treatment of acute and chronic pain. However, their on‐target side effects such as respiratory depression, tolerance and addiction have led to the advent of the ‘opioid crisis’.
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