Results 21 to 30 of about 2,358 (202)
Bile analysis in heroin overdose. [PDF]
, 2007 Following its metabolism in the liver, morphine and its metabolites can be directly eliminated in bile. Then, they undergo the enterohepatic cycle (EHC) and mostly reappear in the circulation. We report a case showing the presence of morphine in bile (21.
C. CACACI +3 more
core +1 more source
Development of natural products as drugs acting on central nervous system
Memorias do Instituto Oswaldo Cruz, 1991 We have recenty studied several natural product constituents which have effects on the CNS. (1) Tetrahydropalmatine (THP) and its analogues were isolated from Corydalis ambigua and various species of Stephania.
Xing-Zu Zhu
doaj +1 more source
Letter: Neonatal-strength ampoules of nalorphine. [PDF]
BMJ, 1976 Daniel Davidson
openaire +4 more sources
BMC Research Notes, 2012 Background Naltrexone has been proven to be an effective treatment option for the treatment of alcohol dependency. In this article we introduce a reliable and simple method developed for the simultaneous determination of naltrexone and 6-β-naltrexol in ...
Heinälä Pekka +5 more
doaj +1 more source
Isolation of Nalorphine Ethereal Sulfate and Nalorphine Glucuronide from Urine of Cat and Rabbit
Experimental Biology and Medicine, 1969 SummaryIsolation of a major metabolite of nalorphine from the urine of the cat was accomplished. This metabolite was nalorphine-3-ethereal sulfate by chemical synthesis of the compound. Evidence is presented to characterize the crystalline metabolite isolated from the urine of the rabbit as nalorphine-3-glucuronide.
Vernon B. Haarstad +2 more
openaire +3 more sources
Unexpected Variation of the Codeine/Morphine Ratio Following Fatal Heroin Overdose [PDF]
, 2014 Postmortem samples from 14 cases of suspected heroin overdose were subjected to a preliminary systematic toxicological analysis in order to highlight the presence of unknown exogenous compounds (e.g., drugs of abuse, alcohol) that may have played a ...
Cippitelli M, Gambaro V, Guerrini K
core +1 more source
Pharmacological Investigations of N-Substituent Variation in Morphine and Oxymorphone: Opioid Receptor Binding, Signaling and Antinociceptive Activity [PDF]
, 2014 Morphine and structurally related derivatives are highly effective analgesics, and the mainstay in the medical management of moderate to severe pain.
A Manglik +42 more
core +3 more sources
THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein‐coupled receptors
British Journal of Pharmacology, Volume 176, Issue S1, Page S21-S141, December 2019., 2019 The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www ...
Stephen P H Alexander +138 more
wiley +1 more source
Pain Research and Management, Volume 1, Issue 2, Page 86-92, 1996., 1996 OBJECTIVE: To investigate the analgesic and nonanalgesic effects and the pharmacokinetics of an intravenous infusion of 2 mg hydromorphone over 20 mins. DESIGN: Open study. SUBJECTS: Twelve healthy volunteers. MEASUREMENTS: The analgesic effect of hydromorphone was evaluated serially using pressure pain thresholds (PPTs) measured on the third fingers ...
D Westerling +3 more
wiley +1 more source
Bivalent and bitopic ligands of the opioid receptors: The prospects of a dual approach
Medicinal Research Reviews, Volume 44, Issue 6, Page 2545-2599, November 2024.Abstract Opioid receptors belonging to the class A G‐protein coupled receptors (GPCRs) are the targets of choice in the treatment of acute and chronic pain. However, their on‐target side effects such as respiratory depression, tolerance and addiction have led to the advent of the ‘opioid crisis’.
Marie Emilie Hovah, Ulrike Holzgrabe
wiley +1 more source