Results 1 to 10 of about 101,541 (346)

Nobody Wants to Be Narcan’d: A Pilot Qualitative Analysis of Drug Users’ Perspectives on Naloxone

Western Journal of Emergency Medicine, 2020
Introduction: Bystander naloxone distribution is an important component of public health initiatives to decrease opioid-related deaths. While there is evidence supporting naloxone distribution programs, the effects of increasing naloxone availability on ...
Jeffrey T. Lai, Charlotte E. Goldfine, Brittany P. Chapman, Melissa M. Taylor, Rochelle K. Rosen, Stephanie P. Carreiro, Kavita M. Babu   +6 more
doaj   +2 more sources

A comparison of intramuscular (Zimhi) and intranasal naloxone (Narcan) in reversal of fentanyl-induced apnea: a randomized, crossover, open-label trial. [PDF]

Nat Commun
Severe opioid-induced respiratory depression (OIRD) can be treated with intranasal (IN) or intramuscular (IM) naloxone. It is relevant to compare their efficacy and determine the optimal strategy to restore breathing following OIRD.
van Lemmen MA, van Velzen M, Sarton EY, Dahan A, Niesters M, van der Schrier RM.   +5 more
europepmc   +2 more sources

Bridging the Gap Between Knowledge and Practices Pertaining to Naloxone Use: A Single-Institution Experience in North Carolina. [PDF]

J Patient Cent Res Rev
Naloxone is a life-saving medication for opioid overdose, which claims many lives annually. This study investigated provider attitudes about, beliefs about, and barriers to naloxone use to inform an increase in provider prescription of naloxone.
Argenyi MS, Bailey G, McLouth CJ, Barnes E, McNeil CJ.   +4 more
europepmc   +2 more sources

Take-home naloxone programs for suspected opioid overdose in community settings: a scoping umbrella review

BMC Public Health, 2021
Background Opioid related overdoses and overdose deaths continue to constitute an urgent public health crisis. The implementation of naloxone programs, such as ‘take-home naloxone’ (THN), has emerged as a key intervention in reducing opioid overdose ...
Amina Moustaqim-Barrette, Damon Dhillon, Justin Ng, Kristen Sundvick, Farihah Ali, Tara Elton-Marshall, Pamela Leece, Katherine Rittenbach, Max Ferguson, Jane A. Buxton   +9 more
doaj   +2 more sources

Preventing opioid overdose with peer-administered naloxone: findings from a rural state

Harm Reduction Journal, 2020
Background In response to the opioid epidemic, naloxone distribution programs aim to prevent overdose death by making naloxone available and training people to use it.
Bridget L. Hanson, Rebecca R. Porter, Amanda L. Zöld, Heather Terhorst-Miller   +3 more
doaj   +2 more sources

Fatal overdose prevention and experience with naloxone: A cross-sectional study from a community-based cohort of people who inject drugs in Baltimore, Maryland.

PLoS ONE, 2020
IntroductionOverdose is a leading cause of death in the United States, especially among people who inject drugs (PWID). Improving naloxone access and carrying among PWID may offset recent increases in overdose mortality associated with the influx of ...
Megan Buresh, Rachel E Gicquelais, Jacquie Astemborski, Gregory D Kirk, Shruti H Mehta, Becky L Genberg   +5 more
doaj   +2 more sources

Higher naloxone dosing in a quantitative systems pharmacology model that predicts naloxone-fentanyl competition at the opioid mu receptor level.

PLoS ONE, 2020
Rapid resuscitation of an opioid overdose with naloxone, an opioid antagonist, is critical. We developed an opioid receptor quantitative systems pharmacology (QSP) model for evaluation of naloxone dosing.
Ronald B Moss, Meghan McCabe Pryor, Rebecca Baillie, Katherine Kudrycki, Christina Friedrich, Mike Reed, Dennis J Carlo   +6 more
doaj   +2 more sources

Racial/ethnic disparities in opioid overdose prevention: comparison of the naloxone care cascade in White, Latinx, and Black people who use opioids in New York City

Harm Reduction Journal, 2023
Background Drug overdose mortality is rising precipitously among Black people who use drugs. In NYC, the overdose mortality rate is now highest in Black (38.2 per 100,000) followed by the Latinx (33.6 per 100,000) and white (32.7 per 100,000) residents ...
Maria R. Khan, Lee Hoff, Luther Elliott, Joy D. Scheidell, John R. Pamplin, T. Townsend, Natalia M. Irvine, Alex S. Bennett   +7 more
semanticscholar   +1 more source

Naloxone Use in Novel Potent Opioid and Fentanyl Overdoses in Emergency Department Patients

JAMA Network Open, 2023
Key Points Question What are the naloxone requirements and clinical sequelae of emergency department patients with novel potent opioid (NPO) overdose exposures?
A. Amaducci, K. Aldy, S. Campleman, Shao Li, A. Meyn, Stephanie Abston, R. Culbreth, A. Krotulski, Barry Logan, P. Wax, J. Brent, A. Manini   +11 more
semanticscholar   +1 more source

Opioid Overdose: Limitations in Naloxone Reversal of Respiratory Depression and Prevention of Cardiac Arrest

Anesthesiology, 2023
Opioids are effective analgesics, but they can have harmful adverse effects, such as addiction and potentially fatal respiratory depression. Naloxone is currently the only available treatment for reversing the negative effects of opioids, including ...
Maarten van Lemmen, J. Florian, Zhihua Li, M. van Velzen, Eveline L. A. van Dorp, M. Niesters, E. Sarton, E. Olofsen, Rutger van der Schrier, D. Strauss, A. Dahan   +10 more
semanticscholar   +1 more source