Results 21 to 30 of about 96,262 (339)

Differential Changes in Expression of Stress- and Metabolic-related Neuropeptides in the Rat Hypothalamus during Morphine Dependence and Withdrawal [PDF]

, 2013
Chronic morphine treatment and naloxone precipitated morphine withdrawal activates stress-related brain circuit and results in significant changes in food intake, body weight gain and energy metabolism.
Ferenczi, Szilamér, Kovács, Krisztina J., Milanes, Victoria M., Nunez, Cristina, Pintér-Kübler, Bernadett, Polyák, Ágnes, Zelei, Edina   +6 more
core   +5 more sources

Predicting pharmacy naloxone stocking and dispensing following a statewide standing order, Indiana 2016 [PDF]

, 2018
BACKGROUND: While naloxone, the overdose reversal medication, has been available for decades, factors associated with its availability through pharmacies remain unclear.
Agley, J.D., Davis, A., Gassman, R., Hoss, A., Jayawardene, W., Meyerson, B.E., Ritchie, K., Ryder, P.T., Shannon, D.J.   +8 more
core   +1 more source

PLACENTAL TRANSFER OF NALOXONE [PDF]

British Journal of Anaesthesia, 1986
Maternal and umbilical venous serum naloxone concentrations were measured after the i.v. (30 mothers) or i.m. (seven mothers) injection of naloxone 400 micrograms. Following i.v. naloxone there was rapid transfer to the fetus and therapeutic plasma concentrations could be expected in 1 or 2 min. However, following i.m.
B.M. Hibbard, D. Davies, M. Rosen
openaire   +4 more sources

A systematic review of opioid prevalence in Australian residential aged care facilities

Australasian Journal on Ageing, Volume 41, Issue 4, Page 501-512, December 2022., 2022
Abstract Objective To systematically review the prevalence of opioid prescribing, dispensing and administration in Australian residential aged care facilities (RACFs). Methods MEDLINE, Embase, CINAHL, AgeLine, Web of Science Core Collection, InformIT and International Pharmaceutical Abstracts (inception to September 2021) were searched for studies ...
Laura A. Dowd, Lorenna Reynolds, Amanda J. Cross, Felicity Veal, Michelle Steeper, Zainab Wanas, Nancy Wu, J. Simon Bell   +7 more
wiley   +1 more source

Effectiveness of an Advanced Naloxone Training, Simulation, and Assessment of Second-Year Pharmacy Students

Pharmacy, 2022
Background: Opioid overdoses continue to be one of the most urgent public health priorities. In 2020, reported overdose deaths in the United States reached a high of over 93,000 cases. As the COVID-19 pandemic and opioid crisis continues to be addressed,
Jennifer Courtney, Eugene Kreys, Bryan Luu, Tiffany Kreys, Ruth Vinall, Vy Quang, Erika Titus-Lay   +6 more
doaj   +1 more source

Homeless drug users' awareness and risk perception of peer "Take Home Naloxone" use – a qualitative study [PDF]

, 2006
BACKGROUND Peer use of take home naloxone has the potential to reduce drug related deaths. There appears to be a paucity of research amongst homeless drug users on the topic.
A Edwards, A Jones, B Powis, D Best, D Bigg, Department of Health, H Joffe, HMSO, J Fountain, J Strang, J Strang, K Dettmer, Katharine Francis, Lesley Jones, M Gossop, N Wright, N Wright, Nat Wright, Nicola Oldham, NMAC, NS Oldham, O Renn, PT O' Driscoll, S Darke, SR Lenton, T Beswick, T Greenhalgh, World Health Organisation   +27 more
core   +3 more sources

Systems analysis and improvement approach to improve naloxone distribution within syringe service programs: study protocol of a randomized controlled trial

Implementation Science, 2023
Background More than half a million Americans died of an opioid-related overdose between 1999 and 2020, the majority occurring between 2015 and 2020. The opioid overdose mortality epidemic disproportionately impacts Black, Indigenous, and people of color
Christopher F. Akiba, Sheila V. Patel, Lynn D. Wenger, Antonio Morgan-Lopez, Gary A. Zarkin, Stephen Orme, Peter J. Davidson, Alex H. Kral, Barrot H. Lambdin   +8 more
doaj   +1 more source

Pain relief devoid of opioid side effects following central action of a silylated neurotensin analog [PDF]

Eur J Pharmacol, 173174 (2020), 2020
Neurotensin (NT) exerts naloxone-insensitive antinociceptive action through its binding to both NTS1 and NTS2 receptors and NT analogs provide stronger pain relief than morphine on a molecular basis. Here, we examined the analgesic/adverse effect profile of a new NT(8-13) derivative denoted JMV2009, in which the Pro10 residue was substituted by a ...
arxiv   +1 more source

Prehospital naloxone administration – what influences choice of dose and route of administration?

BMC Emergency Medicine, 2020
Background Amidst the ongoing opioid crisis there are debates regarding the optimal route of administration and dosages of naloxone. This applies both for lay people administration and emergency medical services, and in the development of new naloxone ...
Ida Tylleskar, Linn Gjersing, Lars Petter Bjørnsen, Anne-Cathrine Braarud, Fridtjof Heyerdahl, Ola Dale, Arne Kristian Skulberg   +6 more
doaj   +1 more source

Risk of respiratory depression with opioids and concomitant gabapentinoids. [PDF]

, 2017
Introduction:The combination of opioids and central nervous system depressants such as benzodiazepines and barbiturates has an additive effect on the frequency of oversedation and respiratory depression requiring naloxone use in hospitalized patients ...
Atayee, Rabia S, Edmonds, Kyle P, Furnish, Timothy, Gunter, Heather, Hsu, Chih, Lee, Kelly C, Savelloni, Julie, Yi, Cassia   +7 more
core   +2 more sources