Results 41 to 50 of about 76,320 (330)

Corticosterone Contributes to Context‐Triggered Retrieval of Morphine Withdrawal Memories by Acting on Basolateral Amygdala Neurons Projecting to Nucleus Accumbens Core

Advanced Science, EarlyView.
Context associated with morphine withdrawal elicits an increase in serum corticosterone levels. Corticosterone participates in CTR‐MWM by acting on MR, but not GR, in the BLA. MR in BLA→NAcC neurons mediates CTR‐MWM. MR increases presynaptic glutamate release and meanwhile participates in D1 receptor‐induced increases in presynaptic glutamate release ...
Zixuan Cao, Yaxian Wen, Yuanqi Chen, Yali Fu, Hao Yang, Chenshan Chu, Xinli Guo, Yu Yuan, Chao Lei, Huan Sheng, Da Shao, Li Yang, Dongyang Cui, Ming Chen, Bin Lai, Ping Zheng   +15 more
wiley   +1 more source

Morphine Tolerance Gated through EZH2‐Mediated Suppression of Trpc5 in Spinal GABAergic Interneurons in Male Mice

Advanced Science, EarlyView.
Chronic morphine suppresses Trpc5 in spinal GABAergic interneurons via EZH2‐mediated histone modification, reducing Ca2+ influx and GABA release. TRPC5 activation enhances morphine analgesia, while EZH2 inhibition restores efficacy and reverses tolerance.
Li Wan, Mengyao Zhang, Haiyue Guo, Yan Xu, Chenjie Xu, Fan Hu, Yinbing Pan, Xian Wang, Wentao Liu, Chun‐Yi Jiang   +9 more
wiley   +1 more source

Analgesic Effects of Fatty Acid Amide Hydrolase Inhibition in a Rat Model of Neuropathic Pain [PDF]

, 2006
Cannabinoid-based medicines have therapeutic potential for the treatment of pain. Augmentation of levels of endocannabinoids with inhibitors of fatty acid amide hydrolase (FAAH) is analgesic in models of acute and inflammatory pain states.
Barrett, David, Chapman, Victoria, Jhaveri, Maulik, Kendall, David, Richardson, Denise   +4 more
core   +2 more sources

Preventing opioid overdose with peer-administered naloxone: findings from a rural state

Harm Reduction Journal, 2020
Background In response to the opioid epidemic, naloxone distribution programs aim to prevent overdose death by making naloxone available and training people to use it.
Bridget L. Hanson, Rebecca R. Porter, Amanda L. Zöld, Heather Terhorst-Miller   +3 more
doaj   +1 more source

Messaging to Increase Public Support for Naloxone Distribution Policies in the United States: Results from a Randomized Survey Experiment. [PDF]

PLoS ONE, 2015
Barriers to public support for naloxone distribution include lack of knowledge, concerns about potential unintended consequences, and lack of sympathy for people at risk of overdose.A randomized survey experiment was conducted with a nationally ...
Marcus A Bachhuber, Emma E McGinty, Alene Kennedy-Hendricks, Jeff Niederdeppe, Colleen L Barry   +4 more
doaj   +1 more source

SAFE – Home Opioid Management Education (SAFE-HOME) in older adults: a naloxone awareness program for home health workers

Drugs in Context, 2021
Background: Older adults (≥65 years) have seen significant increases in opioid overdose deaths. Diversion of older adults’ opioid medication is also a contributor to opioid misuse.
Brianna M McQuade, Mike Koronkowski, Erin Emery-Tiburcio, Robyn Golden, Jennie B Jarrett   +4 more
doaj   +1 more source

Naloxone dosing: An evolving unregulated drug landscape, care setting considerations, and the need for research. [PDF]

Addiction
Addiction, Volume 120, Issue 11, Page 2177-2178, November 2025.
Wong JSH, Lau A, Azar P.
europepmc   +2 more sources

Trends in analgesia prescribing in primary care in Ireland and England between 2014 and 2022: A repeated cross‐sectional study

British Journal of Clinical Pharmacology, EarlyView.
Aims Analgesic medicines are an important component of pain management, with different medicines carrying different risks and benefits. The aim of this study was to examine trends in analgesic prescribing in Ireland and England between 2014 and 2022. Methods Monthly data on medicines prescribed and dispensed in primary care were used. For Ireland, data
Molly Mattsson, Michelle Flood, Brian MacKenna, Emma Wallace, Fiona Boland, Ciara Kirke, Mary E. Walsh, Tom Fahey, Frank Moriarty   +8 more
wiley   +1 more source

Incorporating Naloxone Education Into Routine Primary Care [PDF]

, 2018
Opioid overdoses are a growing public health concern in Vermont and nationwide. Naloxone can save the life of someone who overdoses, if those around them know how to use it.
Goldberg, Eli
core   +1 more source

Modifications of Gait as Predictors of Natural Osteoarthritis Progression in STR/Ort Mice [PDF]

, 2014
Objective. Osteoarthritis (OA) is a common chronic disease for which disease-modifying therapies are not currently available. Studies to seek new targets for slowing the progress of OA rely on mouse models, but these do not allow for longitudinal ...
Poulet, B, De Souza, R, Knights, C B, Gentry, C, Wilson, A M, Bevan, S, Chang, Y M, Pitsillides, A A, Fed Mato Grosso, King's, UCL   +10 more
core   +4 more sources