Results 51 to 60 of about 101,541 (346)

SAFE – Home Opioid Management Education (SAFE-HOME) in older adults: a naloxone awareness program for home health workers

Drugs in Context, 2021
Background: Older adults (≥65 years) have seen significant increases in opioid overdose deaths. Diversion of older adults’ opioid medication is also a contributor to opioid misuse.
Brianna M McQuade, Mike Koronkowski, Erin Emery-Tiburcio, Robyn Golden, Jennie B Jarrett   +4 more
doaj   +1 more source

Are take‐home naloxone programmes effective? Systematic review utilizing application of the Bradford Hill criteria

Addiction, 2016
Background and Aims Fatal outcome of opioid overdose, once detected, is preventable through timely administration of the antidote naloxone. Take‐home naloxone provision directly to opioid users for emergency use has been implemented recently in more than
Rebecca McDonald, J. Strang
semanticscholar   +1 more source

A novel behavioral fish model of nociception for testing analgesics [PDF]

, 2011
Pain is a major symptom in many medical conditions, and often interferes significantly with a person's quality of life. Although a priority topic in medical research for many years, there are still few analgesic drugs approved for clinical use.
Ana D. Correia, Ashley, Barrallo, Bowman, Braithwaite, Breivik, Breivik, Brunner, Chervova, Chervova, Chervova, Cunha, Dunlop, E. Don Stevens, Ehrensing, Friend, Gonzalez-Nunez, Herrero-Turrion, Le Bars, Mansour, Martin Scholze, Matthes, Newby, Newby, Newby, Nordgreen, Nordgreen, Reilly, Ribeiro, Ribeiro, Sanchez-Simon, Sneddon, Sneddon, Sneddon, Sneddon, Sneddon, Stevens, Stevens, Sérgio R. Cunha, Tukey, Wheeler-Aceto, Zon   +41 more
core   +3 more sources

Higher doses of naloxone are needed in the synthetic opiod era

Substance Abuse Treatment, Prevention, and Policy, 2019
There has been a dramatic increase of deaths due to illicit fentanyl. We examined the pharmacology of fentanyl and reviewed data on the number of repeat doses of naloxone used to treat fentanyl overdoses.
R. Moss, D. Carlo
semanticscholar   +1 more source

Use of a novel prescribing approach for the treatment of opioid use disorder: Buprenorphine/naloxone micro-dosing - a case series.

Drug and Alcohol Review, 2020
INTRODUCTION AND AIMS Buprenorphine/naloxone is an evidence-based treatment for opioid use disorder, but an identified limitation is the period of required opioid abstinence prior to induction on the medication.
R. Brar, N. Fairbairn, Christy Sutherland, S. Nolan   +3 more
semanticscholar   +1 more source

Accessibility of Naloxone in Pharmacies Registered Under the Illinois Standing Order

Western Journal of Emergency Medicine
Introduction: To expand access to naloxone, the state of Illinois implemented a standing order allowing registered pharmacies to dispense the drug without an individual prescription.
P. Quincy Moore, Kaitlin Ellis, Patricia Simmer, Mweya Waetjen, Ellen Almirol, Elizabeth Salisbury-Afshar, Mai T. Pho   +6 more
doaj   +1 more source

Case report: Successful induction of buprenorphine/naloxone using a microdosing schedule and assertive outreach

Addiction Science & Clinical Practice, 2020
Background The requirement for moderate withdrawal prior to initiation can be a barrier to buprenorphine/naloxone induction. Case presentation We aimed to use a microdosing regimen to initiate regular dosing of buprenorphine/naloxone in a high-risk ...
J. Rozylo, Keren Mitchell, M. Nikoo, S. E. Durante, Skye P. Barbic, D. Lin, S. Mathias, P. Azar   +7 more
semanticscholar   +1 more source

High‐Throughput Drug Derivatization and Bioassay by Desorption Electrospray Ionization Mass Spectrometry

ChemPlusChem, EarlyView.
Accelerated drug derivatization in microdroplets combined with high‐throughput desorption electrospray ionization mass spectrometry provides rapid reaction screening and label‐free bioassay results, which can expedite drug discovery. Adapting high‐throughput (HT) synthetic methods to the modification of drugs and to testing of their bioactivity should ...
Jyotirmoy Ghosh, Nicolás M. Morato, Yunfei Feng, R. Graham Cooks   +3 more
wiley   +1 more source

An opioid-like system regulating feeding behavior in C. elegans [PDF]

, 2015
Neuropeptides are essential for the regulation of appetite. Here we show that neuropeptides could regulate feeding in mutants that lack neurotransmission from the motor neurons that stimulate feeding muscles. We identified nlp-24 by an RNAi screen of 115
Artyukhin, Alexander B., Avery, Leon, Cheong, Mi Cheong, You, Yong-Jai   +3 more
core   +3 more sources

Take-Home Naloxone for the Emergency Interim Management of Opioid Overdose: The Public Health Application of an Emergency Medicine

Drugs, 2019
Naloxone is a well-established essential medicine for the treatment of life-threatening heroin/opioid overdose in emergency medicine. Over two decades, the concept of ‘take-home naloxone’ has evolved, comprising pre-provision of an emergency supply to ...
J. Strang, Rebecca McDonald, G. Campbell, L. Degenhardt, S. Nielsen, A. Ritter, O. Dale   +6 more
semanticscholar   +1 more source