Results 71 to 80 of about 75,178 (323)
The influence of μ-opioid and noradrenaline reuptake inhibition in the modulation of pain responsive neurones in the central amygdala by tapentadol in rats with neuropathy [PDF]
, 2015 Treatments for neuropathic pain are either not fully effective or have problematic side effects. Combinations of drugs are often used. Tapentadol is a newer molecule that produces analgesia in various pain models through two inhibitory mechanisms, namely
Dickenson, AH, Friend, LV, Gonçalves, L
core
Delayed Neuropsychiatric Syndrome Due to Unrecognized Carbon Monoxide Toxicity: A Case Report
Annals of the Child Neurology Society, EarlyView.ABSTRACT Introduction Carbon monoxide (CO) is a leading cause of poison‐related deaths in children and frequently results in nonspecific neurological symptoms and imaging findings. Rarely, pediatric patients develop a delayed neuropsychiatric syndrome (DNS) following a lucid interval.
Alexandria Valdrighi +3 more
wiley +1 more source
Untrained Bystanders Administering Drone-Delivered Naloxone: An Exploratory Study
Substance Abuse: Research and Treatment, 2023 Introduction: Opioid overdose deaths continue to climb in the United States. Administering naloxone to an overdose victim can save their life, but rapid access to naloxone remains a barrier.
Nicole Adams +4 more
doaj +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Organic cation transporter (OCT) 2 and multidrug and toxin extrusion (MATE) transporters play significant roles in the renal secretion of organic cations and drug–drug interactions (DDIs). Recent in vitro studies indicate that the Ki values for OCT2 exhibit substrate dependency and increase in potency with pre‐incubation.
Satoshi Asano +8 more
wiley +1 more source
The effects of heat and freeze-thaw cycling on naloxone stability
Harm Reduction Journal, 2019 Purpose The availability of take home naloxone (THN) was increased for Canadians in 2016, including access to kits via pharmacies. Unlike typical over-the-counter (OTC) and prescription drugs, THN kits may be stored in non-standard conditions, including ...
Dulcie Lai +3 more
doaj +1 more source
Effectiveness of take ACTION online naloxone training for law enforcement officers
Health & Justice, 2023 Background Training law enforcement officers (LEOs) to administer naloxone is a recommended strategy to reduce overdose deaths in the United States. To achieve this, an evidence-based and scalable naloxone training curriculum that is easy to use and ...
Chin Hwa Dahlem +5 more
doaj +1 more source
Infant Death due to Cannabis Ingestion
Drug Testing and Analysis, EarlyView.ABSTRACT A child died in the emergency room of a local hospital a few hours after ingesting a substance the color of cork and the consistency of earth. At home, a modest amount of resinous substance was found. At the hospital, the child exhibited alterations in walking, balance, and consciousness.
Donata Favretto +9 more
wiley +1 more source
Innovative Drug Delivery and Formulation Designs To Deter Drug Abuse/Misuse Related To Suicide [PDF]
, 2012 Patients with a history of abuse/misuse of pain and psychotic medications are at high risk for suicide. Novel drug delivery and formulation approaches have been explored to reduce the potential of drug abuse/misuse and to improve patient compliance. This
Zhao, Fang
core +1 more source
Biodegradable polymeric prodrugs of naltrexone [PDF]
, 1991 The development of a biodegradable polymeric drug delivery system for the narcotic antagonist naltrexone may improve patient compliance in the treatment of opiate addiction. Random copolymers consisting of the ¿-amino acids N5-(3-hydroxypropyl--glutamine
Adams, N.W. +5 more
core +2 more sources
Drug Testing and Analysis, EarlyView.Close collaboration between an Australian drug checking service and an affiliated university laboratory identifies and characterises the novel synthetic opioid N‐pyrrolidino isotonitazene in an expected oxycodone sample presented by a member of the public.
Blake Curtis +3 more
wiley +1 more source