Results 51 to 60 of about 21,140 (245)
BMC Research Notes, 2012 Background Naltrexone has been proven to be an effective treatment option for the treatment of alcohol dependency. In this article we introduce a reliable and simple method developed for the simultaneous determination of naltrexone and 6-β-naltrexol in ...
Heinälä Pekka +5 more
doaj +1 more source
Harm Reduction Journal, 2012 Background Respiratory depression, a potentially fatal side-effect of opioid-overdose, may be reversed by timely administration of an opioid antagonist, such as naloxone or naltrexone.
Goli Veeraindar +5 more
doaj +1 more source
Alcohol, Clinical and Experimental Research, EarlyView.In a secondary analysis of data from two randomized controlled trials of topiramate in 285 individuals with alcohol use disorder (AUD), measures of genetic risk for problematic alcohol use (PAU) and time to relapse to any drinking (TR) and heavy drinking (THR) significantly moderated topiramate's effect on alcohol‐related problems.
Henry R. Kranzler +8 more
wiley +1 more source
Indian Journal of Psychological Medicine, 2022 Background: Comparative studies of the naturalistic course of patients of opioid dependence on naltrexone and buprenorphine are likely to be helpful for clinical decision-making.
Virendra Vikram Singh +4 more
doaj +1 more source
Power Analysis in a SMART Design: Sample Size Estimation for Determining the Best Dynamic Treatment Regime [PDF]
arXiv, 2018 Sequential, multiple assignment, randomized trial (SMART) designs have become increasingly popular in the field of precision medicine by providing a means for comparing sequences of treatments tailored to the individual patient, i.e., dynamic treatment regime (DTR).
arxiv
Examining the predictive validity of alcohol‐seeking following punishment‐imposed abstinence in mice
Alcohol, Clinical and Experimental Research, EarlyView.Animal models of alcohol use disorder are critical to understand the neurochemical mechanisms underlying this disorder to inform targeted medication development. However, quite often the validity of commonly used animal models remains untested. Here, we optimized a highly used model of abstinence in mice and demonstrated the predictive validity of the ...
Linh Tran +3 more
wiley +1 more source
Addiction Neuroscience, 2023 The non-selective opioid receptor antagonist, naltrexone is one of the most prescribed medications for treating alcohol and opioid addiction. Despite decades of clinical use, the mechanism(s) by which naltrexone reduces addictive behavior remains unclear.
Cory N. Spencer +5 more
doaj
Multi‐ancestry genome‐wide association study of topiramate's effects on heavy alcohol use
Alcohol, Clinical and Experimental Research, EarlyView.Topiramate reduces alcohol consumption, but genetic predictors of treatment response have not been identified. We conducted a GWAS in 8386 individuals from the Million Veteran Program, evaluating genetic variants associated with the change in alcohol consumption before and after initiating topiramate.
Christal N. Davis +4 more
wiley +1 more source
Acta Cirúrgica Brasileira, 2012 PURPOSE: To investigate the effect of the opioid blocker naltrexone in the inflammatory response in acute pancreatitis (AP). METHODS: Acute pancreatitis was induced in anesthetized male Wistar rats by retrograde injection of 2.5% sodium taurocholate ...
Artur Penido +5 more
doaj +1 more source
Acta Psychiatrica Scandinavica, EarlyView.ABSTRACT Objectives Despite the high prevalence of alcohol use disorder (AUD), only a minority of patients receive recommended pharmacological treatments, possibly owing to uncertainty about the real‐world effectiveness of these medications. Here, we analyzed nationwide, register‐based data to investigate the association between approved AUD ...
Patrick Bach +5 more
wiley +1 more source