Results 171 to 180 of about 4,900 (222)

Simultaneous Estimation of Naltrexone Hydrochloride and Zonisamide in Synthetic Mixture by RP-HPLC Method

Research Journal of Pharmacy and Technology
A simple, rapid, precise, and reproducible RP-HPLC method development and validation done for simultaneous estimation of Naltrexone Hydrochloride and Zonisamide in synthetic mixture. The isocratic method was developed usinɡ a Water Symmetry C18 (250 mm X 4.6 mm, 5 µm) column.
Sejal Dhaduk, Nilesh K. Patel, Ashok B. Patel, Amitkumar J Vyas, Ajay I. Patel, Dhruvanshi A. Gol   +5 more
openaire   +2 more sources

Physicochemical Stability of Compounded Naltrexone Hydrochloride Solutions in PCCA Base SuspendIt.

International journal of pharmaceutical compounding, 2019
Naltrexone hydrochloride is an orally active narcotic antagonist used to facilitate rapid transition from methadone maintenance. The dosing schedule of naltrexone hydrochloride in detoxification protocols needs to be flexible to permit precise, customized dose titration for individual patients.
Yashoda V, Pramar, Tarun K, Mandal, Levon A, Bostanian, Anh Tq, Nguyen, Tommy C, Morris, Richard A, Graves   +5 more
openaire   +2 more sources

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Clonidine Hydrochloride Detoxification from Methadone Treatment-

Advances in Alcohol & Substance Abuse, 1984
Treatment outcomes were compared for 2 groups of subjects detoxified from methadone using clonidine. One group of 12 subjects was encouraged to continue in treatment with naltrexone, while the other 12 subjects did not have naltrexone treatment available.
R A, Rawson, A M, Washton, R B, Resnick, F S, Tennant   +3 more
openaire   +3 more sources

Vehicle Composition Influence on the Microneedle-Enhanced Transdermal Flux of Naltrexone Hydrochloride

Pharmaceutical Research, 2010
Transdermal delivery of drugs is often limited by formidable barrier properties of stratum corneum (SC). Microneedles (MN) enable creation of transient microchannels in the SC and bypass this barrier. Many reports have focused on the great effectiveness of MN in improving percutaneous flux values of a variety of drugs over a large molecular size ...
Mikolaj, Milewski, Audra L, Stinchcomb
openaire   +2 more sources

Design of controlled release inert matrices of naltrexone hydrochloride based on percolation concepts

International Journal of Pharmaceutics, 1999
The percolation theory is a statistical theory able to study chaotic or disordered systems that has been applied in the pharmaceutical field since 1987. Through the application of this theory, the design of controlled release inert matrices has been improved.
I, Caraballo, L M, Melgoza, J, Alvarez-Fuentes, M C, Soriano, A M, Rabasco   +4 more
openaire   +2 more sources

Design and Evaluation of Controlled-Release Niosomes and Discomes for Naltrexone Hydrochloride Ocular Delivery

Journal of Pharmaceutical Sciences, 2011
This study aimed at preparing and evaluating Span 60-based niosomes for ocular delivery of naltrexone hydrochloride (NTX). Selected charged lipids [dicetyl phosphate (DCP) and stearyl amine (STA)] and surfactants [poly-24-oxyethylene cholesteryl ether (C24) and sodium cholate (CH)] were investigated as bilayer membrane additives and prepared using four
Hamdy, Abdelkader, Sayed, Ismail, Amal, Kamal, Raid G, Alany   +3 more
openaire   +2 more sources

[Pharmacokinetics of naltrexone hydrochloride and naltrexone glucuronide in the dog].

Yao xue xue bao = Acta pharmaceutica Sinica, 1997
Pharmacokinetics of naltrexone hydrochloride (NTX) and naltrexone glucuronide was studied in the dog using HPLC-electrochemical detection with naloxone as internal standard. After iv 5 mg or po 10 mg NTX, the plasma concentration-time curves of NTX were found to fit to a two-compartment model and a single compartment with first-order absorption.
H, Li, S F, Zhao, N, Wang, Z H, Ge
openaire   +1 more source

Effects of Alcohol on the Pharmacokinetics of Morphine Sulfate and Naltrexone Hydrochloride Extended Release Capsules

The Journal of Clinical Pharmacology, 2012
Although contraindicated, coingestion of alcohol and opioids by patients or drug abusers is a major health concern because of dangerous additive and potentially life‐threatening sedative and respiratory effects. In addition, alcohol has been shown to disrupt the extended‐release characteristics of certain extended‐release opioid formulations, releasing
Franklin K, Johnson, Sabrina, Ciric, Sophie, Boudriau, James, Kisicki, Joseph, Stauffer   +4 more
openaire   +2 more sources

Extended-release morphine sulfate and naltrexone hydrochloride (EMBEDA): naltrexone-associated withdrawal and abuse-related effects in patients with chronic pain and recreational opioid users

Current Medical Research and Opinion, 2018
To review the effects of naltrexone on withdrawal-related adverse events (AEs) and euphoria-related effects, and the relationship between plasma naltrexone concentrations and withdrawal across EMBEDA (MSN; extended-release morphine sulfate with sequestered naltrexone) studies.Five studies in pain patients and a safety review summarizing AE reports ...
Beatrice, Setnik, Kenneth W, Sommerville, Glenn C, Pixton, Lynn, Webster   +3 more
openaire   +2 more sources

A Placebo-Controlled, Double-Blind Crossover Study of Naltrexone Hydrochloride in Outpatients with Normal Weight Bulimia

Journal of Clinical Psychopharmacology, 1989
The endogenous opioid system plays an important role in the control of feeding behavior. Previous research has shown that antagonism of endogenous opioids will suppress feeding in certain models in both human and infrahuman species. In the current study, 16 normal-weight bulimic women were treated with low-dose naltrexone, the long-acting, orally ...
J E, Mitchell, G, Christenson, J, Jennings, M, Huber, B, Thomas, C, Pomeroy, J, Morley   +6 more
openaire   +2 more sources