Results 111 to 120 of about 15,085 (211)

Regulation of Peripheral Molecular Clocks in Mammalian Tissues and In Vitro Skeletal Muscle Activation of AMP-Activated Protein Kinase via AICAR

, 2014
Most organisms possess a common molecular machinery that governs cellular and tissue circadian rhythmicity through a roughly 24-hour transcription-translation feedback loop.
Brandauer, Josef, Lupolt, Alex C., Moorhead, Daniel P.   +2 more
core  

Die Regulation von Nampt nach Myokardinfarkt

, 2014
Das Protein Nampt wurde in der Literatur bereits mehrfach als protektiver Ein-flussfaktor im Zusammenhang mit dem Schutz vor Apoptose von Kardiomyozy-ten sowie der Förderung von Angiogenese von Endothelzellen beschrieben. Auch in vivo konnte eine Verkleinerung der Infarktfläche nach Induktion eines Myokardinfarktes bzw. I/R unter dem Einfluss von Nampt
Jores, Kristina, Justus Liebig University Giessen   +1 more
openaire   +3 more sources

Undercover: Gene control by metabolites and metabolic enzymes [PDF]

, 2016
To make the appropriate developmental decisions or maintain homeostasis, cells and organisms must coordinate the expression of their genome and metabolic state. However, the molecular mechanisms that relay environmental cues such as nutrient availability
Knaap, J.A. (Jan) van der, Verrijzer, C.P. (Peter)   +1 more
core   +2 more sources

Nicotinamide phosphoribosyltransferase expression and clinical outcome of resected stage I/II pancreatic ductal adenocarcinoma.

PLoS ONE, 2019
BackgroundNicotinamide phosphoribosyltransferase (NAMPT) plays a key role in the biosynthesis of nicotinamide adenine dinucleotide (NAD+), which is a vital cofactor in redox reactions and a substrate for NAD+ consuming enzymes including CD38, PARPs and ...
Katelynn Davis, Craig D Dunseth, Sarah L Mott, Kimberly L Cramer-Morales, Ann M Miller, Po Hien Ear, James J Mezhir, Andrew M Bellizzi, Carlos H F Chan   +8 more
doaj   +1 more source

Epigenetic regulation of Runx2 transcription and osteoblast differentiation by nicotinamide phosphoribosyltransferase

Cell & Bioscience, 2017
Background Bone degenerative disorders like osteoporosis may be initiated by age-related shifts in anabolic and catabolic responses that control bone homeostasis.
Min Ling, Peixin Huang, Shamima Islam, Daniel P. Heruth, Xuanan Li, Li Qin Zhang, Ding-You Li, Zhaohui Hu, Shui Qing Ye   +8 more
doaj   +1 more source

Regulation of neutrophil function by NAMPT [PDF]

, 2013
Neutrophils have capacity to cause tissue damage in chronic inflammatory disease. In rheumatoid arthritis (RA) they infiltrate joints, secrete proteases and reactive oxygen species (ROS), and express cytokines. RA neutrophils express NAMPT which is a highly conserved, pleiotropic protein, that catalyses the rate-limiting step of the NAD salvage pathway,
openaire   +1 more source

Circadian and Feeding Rhythms Orchestrate the Diurnal Liver Acetylome. [PDF]

, 2017
Lysine acetylation is involved in various biological processes and is considered a key reversible post-translational modification in the regulation of gene expression, enzyme activity, and subcellular localization. This post-translational modification is
Atger, F., Cantó, C., Collino, S., Da Silva, L., Dayon, L., Gachon, F., Kussmann, M., Martin, E., Martin, F.P., Mauvoisin, D., Montoliu, I., Naef, F., Núñez Galindo, A., Ratajczak, J., Wang, J.   +14 more
core   +1 more source

NAMPT: A pleiotropic modulator of monocytes and macrophages

Pharmacological Research, 2018
Nicotinamide phosphoribosyltransferase (NAMPT) is the bottleneck enzyme of the NAD salvage pathway and thereby is a controller of intracellular NAD concentrations. It has been long known that the same enzyme can be secreted by a number of cell types and acts as a cytokine, although its receptor is at present unknown. Investigational compounds have been
Travelli, Cristina, COLOMBO, GIORGIA, MOLA, Silvia, Genazzani, Armando, Porta, Chiara   +4 more
openaire   +4 more sources

Deletion of Nampt in Projection Neurons of Adult Mice Leads to Motor Dysfunction, Neurodegeneration, and Death

Cell Reports, 2017
Intracellular nicotinamide phosphoribosyltransferase (iNAMPT) is the rate-limiting enzyme of the mammalian NAD+ biosynthesis salvage pathway. Using inducible and conditional knockout (cKO) mice, we show that Nampt gene deletion in adult projection ...
Xiaowan Wang, Qiao Zhang, Ruisi Bao, Nannan Zhang, Yingzhen Wang, Luis Polo-Parada, Andrew Tarim, Aidan Alemifar, Xianlin Han, Heather M. Wilkins, Russell H. Swerdlow, Xinglong Wang, Shinghua Ding   +12 more
doaj   +1 more source

Exploring NAD(+) metabolism in host-pathogen interactions [PDF]

, 2016
Nicotinamide adenine dinucleotide (NAD+) is a vital molecule found in all living cells. NAD+ intracellular levels are dictated by its synthesis, using the de novo and/or salvage pathway, and through its catabolic use as co-enzyme or co-substrate.
Belinha, Ana, Gaifem, Joana, Mesquita, Inês Morais, Silvestre, Ricardo Jorge Leal   +3 more
core   +1 more source