Combined SIRT3 and SIRT5 deletion is associated with inner retinal dysfunction in a mouse model of type 1 diabetes [PDF]
, 2019 Diabetic retinopathy (DR) is a major cause of blindness in working adults in the industrialized world. In addition to vision loss caused by macular edema and pathological angiogenesis, DR patients often exhibit neuronal dysfunction on ...
Apte, Rajendra S. +4 more
core +3 more sources
Tissue-specific regulation of sirtuin and nicotinamide adenine dinucleotide biosynthetic pathways identified in C57Bl/6 mice in response to high-fat feeding [PDF]
, 2016 Funding: The Scottish Government's Rural and Environment Science and Analytical Services Division.Peer ...
Drew, Janice E. +3 more
core +1 more source
Lipids in Health and Disease, 2017 Background Nicotinamide phosphoribosyltransferase (NAMPT) and nicotinamide adenine dinucleotide (NAD) levels are crucial for liver function. The saturated fatty acid palmitate and the unsaturated fatty acid oleate are the main free fatty acids in adipose
Melanie Penke +5 more
doaj +1 more source
Linkage of NAMPT promoter variants to eNAMPT secretion, plasma eNAMPT levels, and ARDS severity
Therapeutic Advances in Respiratory Disease, 2023 Background and objectives: eNAMPT (extracellular nicotinamide phosphoribosyltransferase), a novel DAMP and TLR4 ligand, is a druggable ARDS therapeutic target with NAMPT promoter SNPs associated with ARDS severity.
Heather Lynn +13 more
doaj +1 more source
Visfatin/PBEF/Nampt: A New Cardiovascular Target? [PDF]
Frontiers in Pharmacology, 2010 In the last years, a growing interest has emerged toward understanding the role of adipocytokines in the development of cardio-metabolic complications. Five years ago, visfatin/PBEF/Nampt was identified as a novel adipocytokine. In the context of metabolic disorders, extracellular visfatin/PBEF/Nampt was initially claimed as a potentially beneficial ...
Concepción ePeiró +4 more
openaire +3 more sources
Pharmacological inhibition of nicotinamide phosphoribosyltransferase/visfatin enzymatic activity identifies a new inflammatory pathway linked to NAD. [PDF]
PLoS ONE, 2008 Nicotinamide phosphoribosyltransferase (NAMPT), also known as visfatin, is the rate-limiting enzyme in the salvage pathway of NAD biosynthesis from nicotinamide.
Nathalie Busso +8 more
doaj +1 more source
Gastrointestinal Disorders, 2022 Nicotinamide phosphoribosyltransferase (NAMPT) represents a major component in cellular energy metabolism, which is also crucial for cancer cells that have elevated aerobic glycolysis; moreover, targeting the NAD salvage pathway by inhibition of NAMPT ...
Alexander Arnold +7 more
doaj +1 more source
Dietary fatty acids and vitamin B3: an effective treatment strategy for the metabolic syndrome? [PDF]
, 2015 The metabolic syndrome (MS) may be defined as the constellation of cardiovascular disease (CVD) risk factors that comprises obesity, type 2 diabetes, dyslipidemia, and hypertension. Recent evidences suggest that, primarily due to its high monounsaturated
Abia, Rocío +6 more
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Effects of NAMPT polymorphisms and haplotypes on circulating visfatin/NAMPT levels in hypertensive disorders of pregnancy [PDF]
Hypertension Research, 2015 Dysregulation of adipocytokines may be associated with endothelial dysfunction in women with preeclampsia (PE), who are at increased risk of future cardiovascular disease. Visfatin, an adipocytokine with a potential cardiovascular role, is also known as nicotinamide phosphorybosil transferase (NAMPT).
Luizon, Marcelo R. +8 more
openaire +3 more sources
Journal of Orthopaedic Surgery and Research, 2022 Objective The aim of this study was to investigate the potential role of serum nicotinamide phosphoribosyltransferase (NAMPT) in non-traumatic osteonecrosis of femoral head (NONFH).
Shiying Wang +3 more
doaj +1 more source