Results 61 to 70 of about 15,085 (211)

Substantially Altered Local and Systemic Immunity in Ischemia‐Free Versus Conventional Liver Transplantation

Advanced Science, EarlyView.
This study investigates how ischemia‐free liver transplantation (IFLT) shapes both local and systemic immune responses compared with conventional liver transplantation (CLT). Our findings demonstrate that IFLT confers significant immunological protection by attenuating the STAT3‐HIF‐1α axis and enhancing the Heme‐HMOX1 pathway, two regulatory networks ...
Tao Luo, Shuai He, Shirui Chen, Dongmei Ye, Shibo Zhang, Di Liu, Dawei Zou, Linhe Wang, Huadi Chen, Jinghong Xu, Huanjie Liu, Ruiting Liu, Xi Tan, Yitong Wang, Jiayi Zeng, Runbing Mo, Yuexin Li, Yuyi Zhang, Tanyiyang Ruan, Tielong Wang, Zehua Jia, Yu Jia, Tongdi Fang, Yimou Lin, Xiaorui Liu, Yunhua Tang, Maogen Chen, Qiang Zhao, Anbin Hu, Weiqiang Ju, Yi Ma, Dongping Wang, Xiaofeng Zhu, Schlegel Andrea, Yuan Zhai, Kwan Man, Tullius G. Stefan, Yifang Gao, Jinxin Bei, Xiaoshun He, Zhiyong Guo   +40 more
wiley   +1 more source

Target enzyme mutations are the molecular basis for resistance towards pharmacological inhibition of nicotinamide phosphoribosyltransferase

BMC Cancer, 2010
Background Inhibitors of nicotinamide phosphoribosyltransferase (NAMPT) are promising cancer drugs currently in clinical trials in oncology, including APO866, CHS-828 and the CHS-828 prodrug EB1627/GMX1777, but cancer cell resistance to these drugs has ...
Christensen Mette K, Imai Shin-Ichiro, Yoshino Jun, Kiess Wieland, Garten Antje, Petersen Jakob G, Olesen Uffe H, Fristrup Peter, Thougaard Annemette V, Björkling Fredrik, Jensen Peter B, Nielsen Søren J, Sehested Maxwell   +12 more
doaj   +1 more source

Intracellular NAD+ levels are associated with LPS-induced TNF-α release in pro-inflammatory macrophages [PDF]

, 2016
Bacterial lipopolysaccharide induces changes in intracellular NAD+ levels in a pro-inflammatory, but not an anti-inflammatory, macrophage model that are correlated with the release of the pro-inflammatory cytokine tumour necrosis factor-α (TNF-α).
Abbas Jawad Al-Shabany, Al-Abady, Alan John Moody, Andrew David Foey, Bieganowski, Bruzzone, Daigneault, Dietl, Fedele, Ferrero, Finlay, Galvan-Pena, Holen, Horwitt, Hotamisligil, Howard, Iqbal, Leonardo, Livak, Maciver, Magni, Magni, Murray, Park, Remer, Revollo, Richard Andrew Billington, Riebel, Rongvaux, Schertzer, Schilling, Schwende, Shubinsky, Sutherland, Tavakoli, Van Gool   +35 more
core   +2 more sources

Development of cancer targeted Nampt inhibitors [PDF]

, 2021
The purpose of this research is the discovery of a highly potent pharmaceutical that can selectively cause apoptosis in various cancer cells. To utilize hydrophobic properties of carboranes, 1,7-dicarba-closo-dodecaborane (m-CB) has been selected as a template to synthesize new targeted antitumor agent.
openaire   +2 more sources

Bufalin Inhibits the PI3K/AKT Pathway by Targeting GTF3C4 to Impede Breast Cancer Progression

Advanced Science, EarlyView.
Mechanisms of Bufalin‐Mediated Intervention in Breast Cancer. ABSTRACT Breast cancer incidence is rising globally, presenting challenges such as treatment side effects and drug resistance. Bufalin is a bufadienolides compound with potential anti‐cancer effects. This study shows that bufalin inhibits malignant proliferation of MDA‐MB‐231 and MCF‐7 cells
Siyu Guo, Xiaodong Chen, Haojia Wang, Jiying Zhou, Peiying Lu, Jiangying Liu, Keyan Chai, Jingyuan Zhang, Siyun Yang, Shan Lu, Yifei Gao, Zhengsen Jin, Xiaoyu Tao, Zhongdong Hu, Qinglin Li, Jiarui Wu   +15 more
wiley   +1 more source

NAMPT and BMAL1 Are Independently Involved in the Palmitate-Mediated Induction of Neuroinflammation in Hypothalamic Neurons

Frontiers in Endocrinology, 2020
Obesity is a prominent metabolic disease that predisposes individuals to multiple comorbidities, including type 2 diabetes mellitus, cardiovascular diseases, and cancer. Elevated circulating levels of fatty acids contribute to the development of obesity,
Andy Tran, Wenyuan He, Nan Jiang, Jim T. C. Chen, Denise D. Belsham, Denise D. Belsham, Denise D. Belsham   +6 more
doaj   +1 more source

Targeting cancer metabolism: a therapeutic window opens [PDF]

, 2011
Genetic events in cancer activate signalling pathways that alter cell metabolism. Clinical evidence has linked cell metabolism with cancer outcomes. Together, these observations have raised interest in targeting metabolic enzymes for cancer therapy, but ...
A Clementi, A Dimitrakopoulou-Strauss, A Garten, A Le, A Wolf, A Yalcin, AM Groves, AP Halestrap, AP Pereira da Silva, AS Marsin, B Clem, B Dwarakanath, BA Chabner, BK Mohanti, BR Landau, C Algire, C Derst, C Garcia-Echeverria, C Yang, CH Holdsworth, CM Murray, CS Potten, CV Dang, D Hanahan, D Singh, DA Rew, DA Tennant, DA Tennant, DE Bauer, DK Nomura, DR Wise, DW Parsons, E Eschwege, E Furuta, ED Michelakis, EE Calle, EE Calle, ER Mardis, ES Burgos, G Hatzivassiliou, G Marcucci, G Ollenschlager, GA Spoden, GL Semenza, H Linardou, H Shim, H Yan, HA Hirsch, HR Christofk, HR Christofk, I Maestu, I Papandreou, J Kurhanewicz, J Luo, J Yun, JA Engelman, JA Engelman, JA Menendez, JA Meyerhardt, Jason W Locasale, JB Wang, JD Broome, JG Kidd, JK Jiang, JM Brown, JM Evans, JW Kim, JW Locasale, K Brindle, K Chen, K Duvel, K Holen, K Hosono, K Zaugg, KE Wellen, KH Vousden, KM Kennedy, KS Dimmer, L Dang, L Galluzzi, L Tallal, LG Boros, M Buzzai, M Hasmann, M Ko, M Ookhtens, M Pittelli, M Pollak, M Pollak, M Tahiliani, M Takenaka, M Yuneva, MA Weiser, Matthew G. Vander Heiden, MB Boxer, MB Tessem, MC Li, ME Figueroa, MG Vander Heiden, MG Vander Heiden, MG Vander Heiden, MJ Evans, MJ Holness, MJ Ovens, MJ Seltzer, ML Macheda, ML Tainter, MR Stratton, MS Ardawi, MY El-Mir, N El Mjiyad, N Jaffe, N Normanno, NP Curthoys, NP Manes, NY Kalaany, O Kaplan, P Cocco, P Gao, P Sonveaux, P Thirion, PS Ward, R Chowdhury, R Flavin, R Zhou, R Zoncu, RA Cairns, RA Larson, RB Robey, RB Scott, RE Neuman, RG Jones, RG Maki, RG Verhaak, Richard Possemato, RJ Deberardinis, RJ DeBerardinis, RJ Shaw, RJ Shaw, RL Aft, RM Memmott, S Ben-Haim, S Bonnet, S Bruzzone, S Farber, S Farber, S Gross, S Jiralerspong, S Mazurek, S Stacchiotti, S Telang, SH Jee, SJ Bach, SL Bowker, SM Gallagher, SP Mathupala, T Atsumi, T Cheng, T Shlomi, T Yamamoto, TS Yang, V Chajes, VR Fantin, VT DeVita, W Hu, W Kuo, W Xu, WG Kaelin Jr, Y Kumei, Y Ni, Y Yu, YH Ko   +171 more
core   +1 more source

Multimodal AI‐Driven Identification of Dehydrocostus Lactone as a Potent Renal Fibrosis Attenuator Targeting IQGAP1

Advanced Science, EarlyView.
Renal fibrosis, a hallmark of CKD, lacks effective treatments. Herein, we developed a multimodal AI model (TCM‐SPred) to identify anti‐fibrotic agents and found that dehydrocostus lactone (DCL) targets IQGAP1 to inhibit Wnt signaling, blocking the interaction between IQGAP1 and CCT3, demonstrating potent anti‐fibrotic activity in vitro and in vivo ...
Weijiang Lin, Wenzhuo Xu, Kang Liu, Ping Wang, Zhenzhen Zhu, Wenyu Lu, Zhe Zheng, Xiaoqian Peng, Xunkai Yin, Shulan Mei, An Pan, Jian Liu, Lihong Hu   +12 more
wiley   +1 more source

Zebrafish nampt-a mutants are viable despite perturbed primitive hematopoiesis

Hereditas
Background Nicotinamide phosphoribosyltransferase (Nampt) is required for recycling NAD+ in numerous cellular contexts. Morpholino-based knockdown of zebrafish nampt-a has been shown to cause abnormal development and defective hematopoiesis concomitant ...
Autumn Penecilla Pomreinke, Patrick Müller   +1 more
doaj   +1 more source

Beyond Energy Metabolism: Exploiting the Additional Roles of NAMPT for Cancer Therapy

Frontiers in Oncology, 2020
Tumor cells have increased requirements for NAD+. Thus, many cancers exhibit an increased reliance on NAD+ production pathways. This dependence may be exploited therapeutically through pharmacological targeting of NAMPT, the rate-limiting enzyme in the ...
Christine M. Heske
doaj   +1 more source