Results 161 to 170 of about 14,448 (252)

Engineering Extracellular Vesicles for Anti‐Aging Therapy: Mechanisms, Applications, and Perspectives

Aging Cell, Volume 25, Issue 7, July 2026.
This review systematically elucidates the multifactorial anti‐aging mechanisms of extracellular vesicles (EVs). By bridging fundamental biology with advanced bioengineering, scalable manufacturing, and clinical translation, it establishes a comprehensive framework for developing next‐generation EVs‐based precision nanotherapeutics to combat systemic ...
Xian Huang, Qiujie Li, Guofang Tao, Xulin Gan, Jiangjie Lu, Sergei Krasny, Liyun Shi   +6 more
wiley   +1 more source

NanoBind: Mechanism-Driven Deep Learning of Nanobody-Antigen Molecular Recognition. [PDF]

Research (Wash D C)
Zhao S, Zhu Y, Li R, Xu Z, Han M, Han J, Li Q, Guan M, Wang L, Liu J, Xing L.   +10 more
europepmc   +1 more source

Proteolysis at the extracellular matrix interface: Molecular architects and regulators in health and disease

The FEBS Journal, Volume 293, Issue 13, Page 3758-3787, July 2026.
The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka, Matija Hrovatin, Bor Bokalj, Boris Turk   +3 more
wiley   +1 more source

Revisiting the Antigen 85 Complex as a Target for Functional Antibody-Based Strategies Against <i>Mycobacterium tuberculosis</i>. [PDF]

Microorganisms
Smekenov I, Tleumbetova N, Bektassov S, Bissenbaev A.   +3 more
europepmc   +1 more source

Affinity Enhancement in Discrete Multivalent MegaMolecules

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
We design discrete protein megamolecules with precisely controlled valency (1–6 nanobodies), which exhibit strong avidity‐driven affinity enhancement toward epidermal growth factor receptor and human epidermal growth factor receptor. We systematically investigate the roles of valency, intrinsic affinity, and spatial presentation in optimizing binding ...
Zhaoyi Gu, Blaise R. Kimmel, Justin A. Modica, Che‐Fan Huang, Rahul K. Salaria, Sraeyes Sridhar, Neil L. Kelleher, Milan Mrksich   +7 more
wiley   +1 more source

Nanobody-based analysis of RhoGTPase stress response in <i>Schizosaccharomyces pombe</i>: Role of <i>mtl</i>2. [PDF]

Biotechnol Rep (Amst)
Rasheed N, Ali X, Ali T, Muhammad F, Rasheed MA.   +4 more
europepmc   +1 more source

Nano‐Gs Protein Peptidomimetics: Rational Design of Gα C‐Terminus‐Derived Peptides Mimicking Key Components of Gs‐β2AR Interactions

Angewandte Chemie International Edition, Volume 65, Issue 24, 8 June 2026.
G protein‐coupled receptors (GPCRs) are major therapeutic targets. Modulating GPCR activity through intracellular sites is evolving. A structure‐ and computation‐assisted approach generated small G protein‐derived peptidomimetics targeting the intracellular binding crevice of the β2 adrenergic receptor mimicking features of the full G protein.
Phuong Thu Tran, Mia Danielsen, Johanna K. S. Tiemann, Passainte Ibrahim, Søren G. F. Rasmussen, Xavier Kubiak, Hossein Batebi, Charlène Gadais, Steven Ballet, Peter W. Hildebrand, Daniel Sejer Pedersen, Jesper Mosolff Mathiesen   +11 more
wiley   +1 more source

Generation of Synthetic Acinetobacter baumannii-Specific Nanobodies

The bacterial pathogen Acinetobacter baumannii is a leading cause of drug-resistant infections. Here, we investigated the potential of developing nanobodies that can recognize A. baumannii over other Gram-negative bacteria. Through generation and panning
Gregory A. Knauf (15446313), Angela C. O’Donnell (9867735), Kyra E. Groover (15446316), Bryan W. Davies (15446319)   +3 more
core   +1 more source

Functional Suitability Evaluation of Radioimmunoconjugates of Nanobodies against PD-L1 and HER2/neu for Tumor Theranostics. [PDF]

Sovrem Tekhnologii Med
Avrov KO, Shatik SV, Shashkova OA, Pinevich AA, Terekhina LA, Gryazeva IV, Zaitsev VV, Berlina MA, Stanzhevsky AA, Samoylovich MP.   +9 more
europepmc   +1 more source

Update and reuse: Structure-guided nanobody evolution against SARS-CoV-2 escape. [PDF]

PLoS Pathog
Bu F, Saxena D, Turner-Hubbard H, Delaney A, Batra L, Fricke C, Moye S, Verma A, Perlman S, Bhandari J, Liu B, Ye G, Zheng J, Li F.   +13 more
europepmc   +1 more source