Results 161 to 170 of about 19,910 (273)
Protein Science, Volume 35, Issue 6, June 2026.Abstract Membrane fusion between HIV and host cells requires interaction between the N‐terminal and C‐terminal repeat regions (NHR and CHR) of the gp41 envelope subunit. A deep hydrophobic pocket (HP) on the surface of NHR is considered crucial in this interaction.
Daniel Polo‐Megías +9 more
wiley +1 more source
Protein Science, Volume 35, Issue 6, June 2026.Abstract Accumulation of misfolded proteins is a hallmark of many neurodegenerative diseases. To characterize such misfolded species in vivo, conformation‐specific antibodies are widely used; however, limited knowledge of antibody–epitope interactions often hampers mechanistic insight.
Yuki Shino +7 more
wiley +1 more source
Nanobodies targeting the Epstein-Barr virus EBNA1 DNA binding domain inhibit tumor growth. [PDF]
J NanobiotechnologyWu F +8 more
europepmc +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, Volume 20, Issue 5, Page 1140-1160, May 2026.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Computational nanobody design using graph neural networks and Metropolis Monte Carlo sampling. [PDF]
Brief BioinformWang L, He X, Qian X, Guo G, Huang Q.
europepmc +1 more source
FEBS Open Bio, Volume 16, Issue 5, Page 1030-1043, May 2026.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
Exploring Trop-2-Nanobody PPI Interactions through Molecular Dynamics Simulations and Biovalidations. [PDF]
ACS OmegaCheng J +9 more
europepmc +1 more source
Coacervate‐Mediated Lysosome‐Targeting Antibody Delivery for Protein Degradation
Advanced Science, Volume 13, Issue 25, 4 May 2026.Targeting coacervates to the lysosome in the cytoplasm is a challenge. Here, we convert a tetrapeptide into lysosome‐targeting, membrane‐translocating coacervates. The lysosome‐sorting peptide coacervates facilitate coacervate‐mediated delivery of antibody antigen complexes and a PROTAC compound to the lysosome for the targeted degradation of cancer ...
Dingdong Yuan +7 more
wiley +1 more source
Sensing and Reprogramming Surface Receptor Activation With Synthetic Transcriptional Circuits
Advanced Science, Volume 13, Issue 25, 4 May 2026.A synthetic receptor‐signalling induced transcription (RESIT) circuit is designed based on receptor activation mediated split protease complementation and release of membrane‐tethered synthetic transcriptional modules. The RESIT system enables probing Ca2+ entry, receptor tyrosine kinase (RTK) activities and Ras activation, and reprogramming RTK ...
Fei Liu +5 more
wiley +1 more source