Results 171 to 180 of about 19,910 (273)

Repurpose an FDA‐Approved Antibody Using DARPin‐Scaffolded Bridge Protein

Chemistry–Methods, Volume 6, Issue 5, May 2026.
The cell line and scalable upstream/downstream process development needed for every new monoclonal antibody are both highly expensive and time‐consuming, significantly increasing the cost of new antibody therapeutics. By contrast, the production of many synthetic binders can be accomplished rapidly and with lower production costs.
Michael Woolley, Joshua D. Bryant, Samuel Vrana, Karuppiah Chockalingam, Zhilei Chen   +4 more
wiley   +1 more source

Tiny tools closing the gap: nanobodies in research and therapy. [PDF]

Function (Oxf)
Abdellatif M, Rajurkar J, Leonhardt H.
europepmc   +1 more source

Nanobody tools [PDF]

Nature Methods, 2016
openaire   +1 more source

Surface Plasmon Resonance (SPR) Workflow for Comparative Analysis of Nanobody Variants Binding to Lysozyme as a Model Ligand

Current Protocols, Volume 6, Issue 5, May 2026.
Abstract Developing protein interaction–based technologies such as biosensors requires a clear understanding of receptor‐target kinetics. Nanobodies, which are camelid‐derived single‐domain antibodies, are ideal biosensor receptors due to their high specificity, stability, and ease of production. During biosensor development, multiple nanobody variants
Escarlet Díaz‐Galicia, Nicoleta Gutu, Yuli Peng, Almira Valitova, Dominik Renn, Magnus Rueping   +5 more
wiley   +1 more source

Pfs48/45 nanobodies block Plasmodium falciparum transmission. [PDF]

PLoS Pathog
Lyons FMT, Chmielewski J, Gabriela M, Chan LJ, Tong J, Adair A, Zeglinski K, Gouil Q, Dietrich MH, Tham WH.   +9 more
europepmc   +1 more source

The Ubiquitin Ligase Zinc Finger SWIM Domain‐Containing Protein 8 Regulates Oligodendrocyte Development Through the Argonaute2/MicroRNA‐7 Axis

Glia, Volume 74, Issue 5, May 2026.
ZSWIM8, an E3 ubiquitin ligase that broadly targets IDR‐rich proteins, drives MiR‐7‐dependent AGO2 degradation and the turnover of many RBPs. Loss of ZSWIM8 leads to MiR‐7 accumulation in oligodendrocyte progenitor cells and myelination defects in the developing brain. ABSTRACT Proteostasis of proteins with intrinsically disordered regions (IDRs) is of
Jing Lei, Siming Zhong, Rong Fan, Xin Shu, Guan Wang, Jiansheng Guo, Shuting Xue, Luqian Zheng, Aiming Ren, Junfang Ji, Bing Yang, Shumin Duan, Zhiping Wang, Xing Guo   +13 more
wiley   +1 more source

In vivo CAR therapies: Turning the patient into their own CAR factory

HemaSphere, Volume 10, Issue 5, May 2026.
Abstract Over the past decade, ex vivo autologous chimeric antigen receptor (CAR)‐T‐cell therapies have reshaped the treatment of B‐cell malignancies. Despite their remarkable clinical efficacy, their application remains limited by complex manufacturing processes, demanding logistics, long turnaround times, and substantial costs. In vivo CAR approaches
François Vilcot, Carole‐Anne Brugère, Jaime Fuentealba, Roch Houot   +3 more
wiley   +1 more source

Parallel selection of multiple anti-infectome nanobodies without access to purified antigens [PDF]

, 2008
Baral, Toya Nath, Conrath, Katja, De Baetselier, Patrick, Magez, Stefan, Muyldermans, Serge, Nguyen Thi, Giang Thanh, Saerens, Dirk, Stijlemans, Benoît, Wernery, Ulrich   +8 more
core   +1 more source

A Syndecan‐Based Genetic Approach to Coat the Surface of Small Extracellular Vesicles With Nanobodies

Journal of Extracellular Biology, Volume 5, Issue 5, May 2026.
ABSTRACT Small extracellular vesicles (sEVs) are promising vehicles for targeted therapeutic delivery, but strategies for their surface functionalization remain limited. Here, we present a reliable and simple genetic approach that enables customized modification of sEV surfaces and supports enhanced sEV uptake by recipient cells. This strategy is based
Lukas Hyka, Sofie Meeussen, Rania Ghossoub, Michiel De Coster, Elke De Bruyne, Guido David, Patrick Chames, Pascale Zimmermann   +7 more
wiley   +1 more source

Enhancing the sensitivity of nanobodies through covalent and non-covalent polymerization. [PDF]

RSC Adv
Wang F, Chen J, Chen JH, Liu XM, Hu LQ, Huo LJ.   +5 more
europepmc   +1 more source