Results 91 to 100 of about 19,829 (313)

NanoLAS: a comprehensive nanobody database with data integration, consolidation and application

bioRxiv, 2023
Nanobodies, a unique subclass of antibodies first discovered in camelid animals, are composed solely of a single heavy chain’s variable region (VHH). Their significantly reduced molecular weight, in comparison to conventional antibodies, confers numerous
Shuchang Xiong, Zhengwen Liu, Xin Yi, Kai Liu, Bingding Huang, Xin Wang   +5 more
semanticscholar   +1 more source

Functional Materials Targeted Regulation of Gasdermins: From Fundamentals to Functionalities and Applications

Advanced Science, EarlyView.
Targeted regulation of pyroptosis to modulate the immune landscape is a novel design strategy for cancer immunotherapy and anti‐inflammatory treatment. Pyroptosis, as a double‐edged sword, underscores the importance of optimizing the design strategy of functional materials and appropriately activating pyroptosis for the effective treatment of diseases.
Luyao Tian, Shuo Piao, Xia Li, Lanping Guo, Luqi Huang, Wenyuan Gao   +5 more
wiley   +1 more source

Characterization of Genetic Landscape and Novel Inflammatory Biomarkers in Patients With Adult‐Onset Still's Disease

Arthritis &Rheumatology, EarlyView.
Objective Adult‐onset Still disease (AOSD) is a systemic autoinflammatory disorder (AID) of unknown etiology. Genetic studies have been limited. Here, we conducted detailed genetic and inflammatory biomarker analysis of a large cohort with AOSD to investigate the underlying pathology and identify novel targets for potential treatment.
Joanne Topping, Leon Chang, Fatima Nadat, James A. Poulter, Alice Ibbotson, Samuel Lara‐Reyna, Christopher M. Watson, Clive Carter, Linda P. Pournara, Jan Zernicke, Rebecca L. Ross, Catherine Cargo, Paul A. Lyons, Kenneth G. C. Smith, Francesco Del Galdo, Jürgen Rech, Bruno Fautrel, Eugen Feist, Michael F. McDermott, Sinisa Savic, on behalf of the ImmunAID Consortium   +20 more
wiley   +1 more source

Nogo-A exacerbates sepsis-associated encephalopathy by modulating microglial SHP-2/NLRP3 balance and inducing ROS and M1 polarization

Biomolecules & Biomedicine
Sepsis, a systemic inflammatory response caused by infection, can lead to sepsis-associated encephalopathy (SAE), characterized by brain dysfunction without direct central nervous system infection.
Ying Liu, Lei Guo, Guoan Zhang, Wenjie Sun, Xiaohui Yang, Yingfu Liu   +5 more
doaj   +1 more source

Peptide barcoding for one-pot evaluation of sequence–function relationships of nanobodies

Scientific Reports, 2021
Optimisation of protein binders relies on laborious screening processes. Investigation of sequence–function relationships of protein binders is particularly slow, since mutants are purified and evaluated individually. Here we developed peptide barcoding,
Yusei Matsuzaki, Wataru Aoki, Takumi Miyazaki, Shunsuke Aburaya, Yuta Ohtani, Kaho Kajiwara, Naoki Koike, Hiroyoshi Minakuchi, Natsuko Miura, Tetsuya Kadonosono, Mitsuyoshi Ueda   +10 more
doaj   +1 more source

Evaluation of nanobody-based biologics targeting purinergic checkpoints in tumor models in vivo

Frontiers in Immunology, 2022
Adenosine triphosphate (ATP) represents a danger signal that accumulates in injured tissues, in inflammatory sites, and in the tumor microenvironment. ATP promotes tumor growth but also anti-tumor immune responses notably via the P2X7 receptor.
Mélanie Demeules, Allan Scarpitta, Romain Hardet, Henri Gondé, Catalina Abad, Marine Blandin, Stephan Menzel, Stephan Menzel, Stephan Menzel, Yinghui Duan, Björn Rissiek, Tim Magnus, Anna Marei Mann, Friedrich Koch-Nolte, Sahil Adriouch   +14 more
doaj   +1 more source

Inhalable Nanobody (PiN-21) prevents and treats SARS-CoV-2 infections in Syrian hamsters at ultra-low doses

Science Advances, 2021
Aerosol delivery of an ultrapotent nanobody efficiently prevents and treats SARS-CoV-2 infection. Globally, there is an urgency to develop effective, low-cost therapeutic interventions for coronavirus disease 2019 (COVID-19).
Sham Nambulli, Yufei Xiang, Natasha L. Tilston-Lunel, L. Rennick, Zhe Sang, W. Klimstra, D. Reed, N. Crossland, Yi Shi, W. Duprex   +9 more
semanticscholar   +1 more source

Engineering antibodies with cancer‐associated binding sites

BMEMat, EarlyView.
This review describes antibodies that perform direct/indirect roles in cancer treatment by binding to effective targets and discusses how antibodies kill tumors and modulate tumor microenvironment through these targets. The classification of expression systems for antibody production is summarized to guide appropriate selection based on different ...
Yinqi Tian, Yumeng Pan, Yingchun Zhang, Fangling Wang, Zejun Wang   +4 more
wiley   +1 more source

α-Synuclein fibril-specific nanobody reduces prion-like α-synuclein spreading in mice

Nature Communications, 2022
Pathogenic α-synuclein (α-syn) is a prion-like protein that drives the pathogenesis of Lewy Body Dementia (LBD) and Parkinson’s Disease (PD). To target pathogenic α-syn preformed fibrils (PFF), here we designed extracellular disulfide bond-free synthetic
Yemima R Butler, Yuqing Liu, Ramhari Kumbhar, Peiran Zhao, Kundlik Gadhave, Ning Wang, Yanmei Li, Xiaobo Mao, Wenjing Wang   +8 more
semanticscholar   +1 more source

Evaluation of the yeast surface display system for screening of functional nanobodies

AMB Express, 2020
Yeast surface display is a powerful technology used to isolate and engineer proteins to improve their activity, specificity, and stability. In this method, gene expression is regulated by promoters, and secretion efficiency is affected by secretion ...
Kaho Kajiwara, Wataru Aoki, Mitsuyoshi Ueda   +2 more
doaj   +1 more source