Nanobody Repertoires for Exposing Vulnerabilities of SARS-CoV-2 [PDF]
, 2021 Fred D. Mast +27 more
openalex +1 more source
Arthritis &Rheumatology, Accepted Article.Objective The spontaneous K/BxN mouse model of rheumatoid arthritis has been used extensively to study chronic inflammation, contribution of immune cells, and the primordial role of autoreactive antibodies in disease initiation and severity. Only the ubiquitous enzyme glucose‐6‐phosphate isomerase (GPI) is the target of IgG autoantibodies secreted by ...
Thibault Vanhoucke +8 more
wiley +1 more source
A Novel Anti-CD47 Nanobody Tetramer for Cancer Therapy
AntibodiesCD47 acts as a defense mechanism for tumor cells by sending a “don’t eat me” signal via its bond with SIRPα. With CD47’s overexpression linked to poor cancer outcomes, its pathway has become a target in cancer immunotherapy.
Nataliya M. Ratnikova +5 more
doaj +1 more source
The atomistic level structure for the activated human κ-opioid receptor bound to the full Gi protein and the MP1104 agonist [PDF]
, 2020 The kappa opioid receptor (κOR) is an important target for pain therapeutics to reduce depression and other harmful side effects of existing medications.
Goddard, William A., III +2 more
core +1 more source
Elucidation of the molecular mechanisms of two nanobodies that inhibit thrombin‐activatable fibrinolysis inhibitor activation and activated thrombin‐activatable fibrinolysis inhibitor activity [PDF]
, 2016 Xiaohua Zhou +5 more
openalex +1 more source
Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases
BMEMat, EarlyView.This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou +6 more
wiley +1 more source
NanoBERTa-ASP: predicting nanobody paratope based on a pretrained RoBERTa model
BMC BioinformaticsBackground Nanobodies, also known as VHH or single-domain antibodies, are unique antibody fragments derived solely from heavy chains. They offer advantages of small molecules and conventional antibodies, making them promising therapeutics.
Shangru Li +4 more
doaj +1 more source
Versatile, Multivalent Nanobody Cocktails Efficiently Neutralize SARS-CoV-2 [PDF]
, 2020 Yufei Xiang +8 more
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Nanobodies identify an activated state of the TRIB2 pseudokinase [PDF]
, 2022 Sam A. Jamieson +5 more
openalex +1 more source
Effect of cell retention techniques in Komagataella phaffii lab‐scale continuous processes
Biotechnology Progress, EarlyView.Abstract Perfusion technologies play a growing role in the implementation of continuous processes for biotherapeutics production in mammalian‐based manufacturing. However, their application to alternative production hosts is limited. Cell retention systems are of key importance for the efficiency of perfusion bioreactors.
Marina Y. Linova +5 more
wiley +1 more source