Intratumoral Microbiota in Fueling Cancer and Steering Treatment Response
MedComm, Volume 7, Issue 10, October 2026.Emerging research underscores the tumor‐specific colonization of microbiota and the role of intratumoral microbiota in cancer development and treatment resistance across multiple malignancies. Here, we provide a systematic review exploring the latest biotechnological advancements for studying low‐abundance intratumoral microbiota, their origins ...
Minhui Xu +7 more
wiley +1 more source
Nanobodies targeting SARS-CoV-2 papain-like protease exert dual antiviral and anti-inflammatory effects. [PDF]
J VirolLiu G +11 more
europepmc +1 more source
Precisely Engineering Biomimetic Nanoparticles via Controlled Cell Membrane Coating
Small, Volume 22, Issue 55, 1 October 2026.Precise engineering of cell membrane‐coated nanoparticles (CMNPs) requires coordinated control over particle size, coating integrity, and membrane leaflet orientation. This review integrates key synthesis parameters, assembly strategies, and analytical methods that govern these features, revealing how structural control underpins biomimetic function ...
Jie Lay Lim +4 more
wiley +1 more source
Microbial Biotechnology, Volume 19, Issue 10, October 2026.Schematic diagram of the core pathogenic pathway by which E. coli drives IgAN.E. coli expansion in IgAN is driven by host, environmental and ecological factors, and promotes disease progression via two core pathways: LPS‐induced immune activation and pyroptosis, and metabolite‐mediated remote regulation, leading to Gd‐IgA1 overproduction, mesangial ...
Yuxin Liu +7 more
wiley +1 more source
Exploring the CD38-Associated Surfaceome via Nanobody-Targeted TurboID. [PDF]
Mol Cell ProteomicsFeng K +7 more
europepmc +1 more source
Dualsteric and dual‐acting modulation of muscarinic receptors by antagonist KH‐5
British Journal of Pharmacology, Volume 183, Issue 19, Page 5769-5790, October 2026.Abstract Background and purpose Muscarinic acetylcholine receptors are key therapeutic targets, and ligands engaging both orthosteric and allosteric sites may offer improved selectivity and efficacy. Here, we investigated whether the muscarinic antagonist KH‐5 acts as a dualsteric antagonist and defined its mode of interaction with muscarinic receptors.
Alena Janoušková‐Randáková +3 more
wiley +1 more source
Screening and Preliminary Identification of Inhibin α Subunit-Specific Nanobodies Through High-Throughput Sequencing Combined with Mass Spectrometry. [PDF]
Animals (Basel)Ma J +4 more
europepmc +1 more source
A Noncanonical Protein Degradation Pathway That Regulates Germ Cell Maintenance
Cell Proliferation, Volume 59, Issue 10, October 2026.SENP8 regulates a non‐canonical NEDD8‐dependent pathway to stabilize STAT1, promote CCL2/CCL5 transcription, and maintain germ cell proliferation and migration.
Meng Liu +11 more
wiley +1 more source
Screening and Engineering of Hetero-Bivalent Nanobody Targeting Interleukin-33 with Enhanced Binding Stability. [PDF]
BiomoleculesZhou Y, Shi L, Wang W.
europepmc +1 more source
Nanorulers for Super‐Resolution Microscopy
ChemBioChem, Volume 27, Issue 18, 28 September 2026.Nanorulers serve as essential calibration standards to validate optical super‐resolution microscopy down to the Ångström scale. Complementary DNA‐, protein‐, and virus‐based scaffolds provide unique strategies to benchmark spatial resolution, evaluate quantitative labeling efficiency, and mini‐mize linkage errors.
Gerti Beliu +5 more
wiley +1 more source