Results 181 to 190 of about 16,460 (261)

Affinity Enhancement in Discrete Multivalent MegaMolecules

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
We design discrete protein megamolecules with precisely controlled valency (1–6 nanobodies), which exhibit strong avidity‐driven affinity enhancement toward epidermal growth factor receptor and human epidermal growth factor receptor. We systematically investigate the roles of valency, intrinsic affinity, and spatial presentation in optimizing binding ...
Zhaoyi Gu, Blaise R. Kimmel, Justin A. Modica, Che‐Fan Huang, Rahul K. Salaria, Sraeyes Sridhar, Neil L. Kelleher, Milan Mrksich   +7 more
wiley   +1 more source

Nanobody-engineered CLL-1 CAR T cells: A strategy for safer targeting in acute myeloid leukemia. [PDF]

Mol Ther Oncol
Tripathi C, Luh F, Yen Y.
europepmc   +1 more source

Animation of the complex between Arc-NL and nanobody E5.

Animation of the complex between Arc-NL and nanobody E5.
Aleksi Sutinen (10039145), Oda C. Krokengen (6812267), Sarah Weber (153709), Andrea J. Lopez (4990781), José M. Godoy Muñoz (18462075), Lasse Neset (18215919), Sigurbjörn Markússon (10803121), Eleni Christakou (11731539), Clive R. Bramham (10181909), Petri Kursula (90066)   +9 more
core   +1 more source

Nano‐Gs Protein Peptidomimetics: Rational Design of Gα C‐Terminus‐Derived Peptides Mimicking Key Components of Gs‐β2AR Interactions

Angewandte Chemie International Edition, Volume 65, Issue 24, 8 June 2026.
G protein‐coupled receptors (GPCRs) are major therapeutic targets. Modulating GPCR activity through intracellular sites is evolving. A structure‐ and computation‐assisted approach generated small G protein‐derived peptidomimetics targeting the intracellular binding crevice of the β2 adrenergic receptor mimicking features of the full G protein.
Phuong Thu Tran, Mia Danielsen, Johanna K. S. Tiemann, Passainte Ibrahim, Søren G. F. Rasmussen, Xavier Kubiak, Hossein Batebi, Charlène Gadais, Steven Ballet, Peter W. Hildebrand, Daniel Sejer Pedersen, Jesper Mosolff Mathiesen   +11 more
wiley   +1 more source

Cell-type-targeted mitochondrial transplantation rescues cell degeneration. [PDF]

Nature
Ayupov T, Moreno-Juan V, Curtoni S, Fratzl A, Sharma U, Posada-Céspedes S, Ratiu R, Morikawa R, Meyer AG, Pezzoli M, Bantug G, Chevalier M, Hou Y, Nadeau SA, Herrero-Navarro Á, Ayinampudi V, Kastanaki E, Whitehead N, Siwicki RA, Ribeiro MM, Han JH, Bucci A, Hess C, Picelli S, Renner M, Müller DJ, Cowan CS, Hansen S, Roska B.   +28 more
europepmc   +1 more source

SENSIT, a Modular Single-Chain Fluorescent Integrator Platform for GPCR Ligands. [PDF]

ACS Chem Biol
Putansu A, Solowiej I, Rivett-Trznadel H, Lakkanasirorat B, Moran L, Kroning KE, Liu J, Li X, Li P, Wang W.   +9 more
europepmc   +1 more source

A Nanobody-LNP Platform for Targeting and Relicensing Dendritic Cells for Potent Cancer Immunotherapy. [PDF]

Adv Sci (Weinh)
Qin S, Huang Z, Huang H, Zhang Y, Chen Y, He X, Niu Z, Xiang Z, Zou C, Song X.   +9 more
europepmc   +1 more source

Update and reuse: Structure-guided nanobody evolution against SARS-CoV-2 escape. [PDF]

PLoS Pathog
Bu F, Saxena D, Turner-Hubbard H, Delaney A, Batra L, Fricke C, Moye S, Verma A, Perlman S, Bhandari J, Liu B, Ye G, Zheng J, Li F.   +13 more
europepmc   +1 more source

Adaptive Disorder as the Hallmark of Nanobodies Antigen-Binding Loops. [PDF]

J Chem Inf Model
Bagordo D, Trèves G, Santorsola M, Colombo G, Lescai F.   +4 more
europepmc   +1 more source

Nanobody tools [PDF]

Nature Methods, 2016
openaire   +1 more source