Results 171 to 180 of about 18,503 (241)

AVIDbase: A biologically accurate structural dataset of nanobody-antigen complexes. [PDF]

Protein Sci
Medved T, Lah J, Miličić G, Hadži S.
europepmc   +1 more source

Massive Sampling Strategy for Antibody–Antigen Targets in CAPRI Round 55 With MassiveFold

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 11, Page 1768-1776, November 2026.
ABSTRACT Massive sampling with AlphaFold2 improves protein–protein complex predictions. This has been shown during the last CASP15‐CAPRI blind prediction round by the AFsample tool. However, more difficult targets including antibody–antigen binding remain challenging. CAPRI Round 55 consisted of three antibody–antigen targets and one heterotrimer.
Nessim Raouraoua, Marc F. Lensink, Guillaume Brysbaert   +2 more
wiley   +1 more source

Siglec-1-targeted nanobodies restrict HIV-1 transmission and infection of dendritic cells. [PDF]

J Virol
Man S, Affandi AJ, Brink HJ, van Hamme JL, Konijn VAL, Stolwijk JGC, den Haan JMM, Kootstra NA, Geijtenbeek TBH.   +8 more
europepmc   +1 more source

Biomolecular Interaction Prediction in the Pre‐ and Post‐AlphaFold Era: The 8th CAPRI Evaluation

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 11, Page 1813-1826, November 2026.
ABSTRACT We report on the 8th CAPRI Evaluation period, capturing the assessment of CAPRI Rounds 47 to 55 (excluding the CASP and COVID‐related Rounds), which have witnessed the transition to AI‐driven prediction tools such as AlphaFold and related alternatives. The prediction Rounds in this evaluation are characterized by a high level of difficulty due
Marc F. Lensink, Nessim Raouraoua, Guillaume Brysbaert, Sameer Velankar, Shoshana J. Wodak, Alexandre M. J. J. Bonvin   +5 more
wiley   +1 more source

Analysing open-source protein folding models for nanobody binding prediction. [PDF]

Front Bioinform
Vogt Y, Roßberg R, Habermann J, Kluge P, Xu W, Naouar M, Hirschberg S, Miething C, Bödecker J, Kalweit M, Ullrich E, Kalweit G.   +11 more
europepmc   +1 more source

Performance of pyDock in 8th CAPRI: Energy‐Based Scoring Applied to Docking and AlphaFold Models

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 11, Page 1827-1835, November 2026.
ABSTRACT The 8th CAPRI edition has shown a significant evolution in the field of protein–protein complex structure prediction. We have participated in all 11 targets proposed in this edition, involving domain‐domain, protein–protein, protein‐peptide, and protein‐DNA interactions, including homo‐ and hetero‐meric interfaces.
Luis Angel Rodríguez‐Lumbreras, Mireia Rosell, Miguel Romero‐Durana, Víctor Monteagudo, Fabian Glaser, Juan Fernandez‐Recio   +5 more
wiley   +1 more source

Farnesyltransferase Enables Modular Assembly of Dual‐Functional Nanobody Conjugates for in Vivo Imaging of Inflammation

Angewandte Chemie, Volume 138, Issue 42, 12 October 2026.
A modular farnesyltransferase‐based chemoenzymatic platform enables fast, site‐specific labeling of nanobodies for PET imaging of inflammation. CD11b‐targeted PET agents selectively image myeloid‐driven inflammation, while CD45‐targeted PET agents provide sensitive whole‐body immune mapping.
Sneha Venkatachalapathy, Yoon Ho Lee, Ali Salehi Farid, Heydar Moravej, Sina Djafari Rouhani, Jennifer E. Rowley, Mohammad Rashidian, Mark D. Distefano   +7 more
wiley   +2 more sources

Multimerization and Conjugation to Antiviral and Cytotoxic Payloads Enhance the Activity of Virus-Neutralizing Nanobodies In Vitro. [PDF]

ACS Omega
Zhuchkov VA, Kruglova NA, Kamzeeva PN, Siniavin AE, Konovalova EV, Schulga AA, Gulyak EL, Sapozhnikova KA, Deyev SM, Yanvarev DV, Aralov AV, Chumakov SP.   +11 more
europepmc   +1 more source

Mapping of C5‐Blocking Monoclonal Antibodies Reveals New C5 Inhibitory Epitopes and Novel Modes of C5 Inhibition

Immunology, Volume 179, Issue 3, Page 444-456, November 2026.
We identify four distinct C5 inhibitory epitopes, including two novel antibodies that selectively block membrane attack complex (MAC) assembly while preserving C5 cleavage and C5a generation. These findings establish selective MAC inhibition as a new therapeutic strategy for complement‐mediated diseases.
Rebekah Sian Cooke, Kok Yung Lee, Georgina Elizabeth Menzies, Masashi Mizuno, Bryan Paul Morgan, Wioleta Milena Zelek   +5 more
wiley   +1 more source

Multimerization of a rationally designed nanobody for enhanced avidity toward Aβ42 oligomers. [PDF]

Protein Sci
Nowinska M, Suh E, Mogilevsky C, Vendruscolo M.   +3 more
europepmc   +1 more source