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Exploiting Nanobodies’ Singular Traits
Annual Review of Immunology, 2018The unique class of heavy chain–only antibodies, present in Camelidae, can be shrunk to just the variable region of the heavy chain to yield VHHs, also called nanobodies. About one-tenth the size of their full-size counterparts, nanobodies can serve in applications similar to those for conventional antibodies, but they come with a number of signature ...
Jessica R, Ingram +2 more
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Nanobodies and Their Potential Applications
Nanomedicine, 2013Nanobodies are recombinant, antigen-specific, single-domain, variable fragments of camelid heavy chain-only antibodies. The innate supremacy of nanobodies as a renewable source of affinity reagents, together with their high production yield in a broad variety of expression systems, minimal size, great stability, reversible refolding and outstanding ...
Gholamreza Hassanzadeh-Ghassabeh +4 more
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Science Signaling
Antibody fragments can act as pharmacological tools to modulate the functions of G protein–coupled receptors.
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Antibody fragments can act as pharmacological tools to modulate the functions of G protein–coupled receptors.
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Trends in nanobody radiotheranostics
European Journal of Nuclear Medicine and Molecular ImagingAs the smallest antibody fragment with specific binding affinity, nanobody-based nuclear medicine has demonstrated significant potential to revolutionize the field of precision medicine, supported by burgeoning preclinical investigations and accumulating clinical evidence.
Xingru Long +4 more
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Optogenetic Activation of Intracellular Nanobodies
2022Intracellular antibody fragments such as nanobodies and scFvs are powerful tools for imaging and for modulating and neutralizing endogenous target proteins. Optogenetically activated intracellular antibodies (optobodies) constitute a light-inducible system to directly control intrabody activities in cells, with greater spatial and temporal resolution ...
Daseuli, Yu, Heo, Won Do
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Nanobodies in therapeutic applications.
Current opinion in molecular therapeutics, 2007Over the years, many antibodies have been successfully generated to treat patients with life-threatening diseases, most notably cancer. While the first generation of antibodies, originating from mice, caused severe side effects and were relatively inefficient, technological advances have made it possible to obtain fully human antibodies for therapeutic
Roovers, Rob C. +2 more
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Nanobodies: Natural Single-Domain Antibodies
Annual Review of Biochemistry, 2013Sera of camelids contain both conventional heterotetrameric antibodies and unique functional heavy (H)-chain antibodies (HCAbs). The H chain of these homodimeric antibodies consists of one antigen-binding domain, the VHH, and two constant domains.
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Nanobody exchange chromatography
2021The present invention relates to the field of affinity purification and provides for means and methods applying protein binding agents competing for a target protein for use as capture and elution tool, wherein the elution agent comprises an immunoglobulin single variable domain (ISVD), and is capable of displacing the capturing binding agent.
Steyaert, Jan +6 more
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