Results 111 to 120 of about 1,298 (145)

Ginsenoside Rg1 alleviates post-ischemic stroke neuroinflammation by inhibiting CKLF1-mediated suppression of dead/dying neuron clearance. [PDF]

Acta Pharm Sin B
Fan P, Ruan Y, Hu K, Wang H, Ye J, Wang S, Yuan R, Yang G, Liu F, He W, Li G, Yan X, Chu S, Zhang Z, Chen N.   +14 more
europepmc   +1 more source

Multicolored sequential resonance energy transfer for detection of simultaneous ligand binding at G protein-coupled receptors. [PDF]

Nat Commun
Valentini A, Dibnah B, Ciba M, Duncan EM, Manandhar A, Strellis B, Vita L, Lucianno O, Massey C, Coe S, Ulven T, Hudson BD, Rexen Ulven E.   +12 more
europepmc   +1 more source

Un-LOK-ing a New Approach for Conformational Selective Targeting of STK10 (LOK). [PDF]

ACS Med Chem Lett
Dettenhöfer M, Tandara LN, Amrhein JA, Kurz CG, Schwalm MP, Mensing TE, Wahl LM, Krämer A, Gerninghaus J, Lenz C, Elson L, Berger BT, Schröder M, Saxena K, Müller S, Knapp S, Greco FA, Hanke T.   +17 more
europepmc   +1 more source

Ebola virus VP35 NNLNS motif modulates viral RNA synthesis and MIB2-mediated signaling. [PDF]

Proc Natl Acad Sci U S A
Uwase G, Luthra P, Vogel OA, Batra J, La Rosa BA, Sheehan KCF, Khatavkar O, Payton JE, Davey RA, Krogan NJ, Basler CF, Leung DW, Amarasinghe GK.   +12 more
europepmc   +1 more source

Overcoming Ligand Discovery Challenges: Developing Peptide-Based Tracers for SPSB2. [PDF]

ACS Chem Biol
Lenz C, Elson L, Dopfer J, Farges F, Krämer A, Löhr F, Müller S, Guéret SM, Waldmann H, Dötsch V, Saxena K, Knapp S.   +11 more
europepmc   +1 more source

A NanoBRET-based assay monitoring interactions in the USP18 signaling hub identifies the first cell-penetrant small molecule compromising USP18/ISG15 binding

Hess S, Alonso MC, Brand M, Lauw S, Lindenmann U, Göbel K, Geurink PP, Fritz G, Riedl R, Knobeloch K.   +9 more
europepmc   +1 more source

Investigation of Receptor Heteromers Using NanoBRET Ligand Binding [PDF]

International Journal of Molecular Sciences, 2021
Receptor heteromerization is the formation of a complex involving at least two different receptors with pharmacology that is distinct from that exhibited by its constituent receptor units. Detection of these complexes and monitoring their pharmacology is crucial for understanding how receptors function.
Elizabeth Johstone, Kevin Pfleger, Stephen Hill   +2 more
exaly   +5 more sources

Development of NanoBRET‐Binding Assays for FKBP‐Ligand Profiling in Living Cells [PDF]

ChemBioChem, 2021
AbstractFK506‐binding proteins (FKBPs) are promising targets for a variety of disorders and infectious diseases. High FKBP occupancy is thought to be necessary for ligands to effectively compete with the endogenous intracellular functions of FKBPs. Here, we report the development of NanoBRET assays for the most prominent cytosolic FKBPs, FKBP12, 12.6 ...
Felix Hausch, Jürgen Kolos
exaly   +3 more sources

NanoB2 to monitor interactions of ligands with membrane proteins by combining nanobodies and NanoBRET

Cell Reports Methods, 2023
The therapeutic potential of ligands targeting disease-associated membrane proteins is predicted by ligand-receptor binding constants, which can be determined using NanoLuciferase (NanoLuc)-based bioluminescence resonance energy transfer (NanoBRET) methods.
Raimond Heukers
exaly   +4 more sources

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NanoBRET Approaches to Study Ligand Binding to GPCRs and RTKs

Trends in Pharmacological Sciences, 2018
Recent advances in the development of fluorescent ligands for G-protein-coupled receptors (GPCRs) and receptor tyrosine kinase receptors (RTKs) have facilitated the study of these receptors in living cells. A limitation of these ligands is potential uptake into cells and increased nonspecific binding.
Laura Kilpatrick, Stephen Hill, Leigh Stoddart   +2 more
exaly   +3 more sources