Results 121 to 130 of about 13,099 (249)

Synergistic p53 Pathway Activation Through Sono‐Gene Therapy Induced by Ultrasound‐Triggered Theranostic Mesoporous Nanoparticles

Advanced Science, EarlyView.
Schematic representation of ultrasound‐mediated ICG/siCD24@MSN‐LCD from nanostructure to synergistic sono‐gene therapy. This nanoplatform targets ASGPR via the LCD shell, which dissociates to release loaded ICG and siCD24. The core mechanism involves ultrasound‐guided sonodynamic therapy by ICG and CD24 knockdown by siCD24, both activating the p53 axis
Yading Zhao, Lu Guo, Dandan Shi, Xiao Sun, Mengmeng Shang, Song Ning, Shuting Huang, Xiaoxuan Wang, Rui Liu, Yuye Fu, Suyun Li, Jie Li   +11 more
wiley   +1 more source

Mesoporous Silica Nanoparticle as a Potential Nanocarrier to Improve the Effectiveness of Antiobesity Drugs

Diabetes, Metabolic Syndrome and Obesity
Diah Lia Aulifa,1 Siti Nunung Nurulaini,1 Zahra Noor Silmi Hermawan Ayodduki,1 Joseph Fide Anggi,1 Joshua Harry Chandra,2 Arif Budiman2 1Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang,
Aulifa DL, Nurulaini SN, Ayodduki ZNSH, Anggi JF, Chandra JH, Budiman A   +5 more
doaj  

Nanocarrier-mediated cell-cell binding in vitro.

, 2016
A. Schematic illustration of the design of nanocarriers with a representative image of the desired biological readout. “Mono-arm” (Ac-G5-dendrimer-sE-sel, Left) and “double-arm” (Ac-G5-dendrimer-sE-sel/VEGF, Right) for EPC coating. B.
Bo Wang (86769), Zhao-Jun Liu (168517), Sylvia Daunert (587439), Letícia Kovalski (2623045), Sapna Deo (2408800), Emre Dikici (2043049), Omaida C. Velazquez (320006), Victor L. Perez (524545), Runxia Tian (2623048), Pirouz Daftarian (2623051), Diego M. Castilla (2623054)   +10 more
core   +1 more source

Engineered Xenogeneic Bone Scaffold with IL‐10 Nanodelivery System: Immunomodulation and BMSC Fate Programming for Skull Defect Repair

Advanced Science, EarlyView.
A multifunctional regenerative composite is constructed by 3D‐printing thermosensitive PNIPAM hydrogel embedded with MPDA@IL‐10 nanoparticles and autologous BMSCs onto antigen‐depleted porcine bone matrix for beagle critical‐sized skull defect reconstruction.
Weihao Lv, Lei Zhang, Fei Fei, Zhibin Wu, Xiuquan Wu, Ya‐nan Dou, Yihao Fu, Hao Chang, Yujie Qiang, Huaxia Xie, Ni An, Leiying Chen, Hongchen Zhang, Min‐Wen Zheng, Hongqing Chen, Xia Li, Zhou Fei   +16 more
wiley   +1 more source

Engineering Morphological Anisotropy to Control the In Vivo Transport Dynamics, Clearance, and Biodistribution of Silica Nanocarriers

Advanced Science, EarlyView.
Morphological anisotropy directs the in vivo transport under physiological flow and clearance of silica nanocarriers. Increasing anisotropy reduces cellular uptake, suppresses hepatic and splenic sequestration, and prolongs systemic circulation by steering particles toward the central flow core.
Xiaofei Li, Yingjie Yu, Tianchang He, Xiaoyan Fang, Wenhua Yang, Luying Zhou, Hao Fan, Guimei Lin, Daniel Crespy, Katharina Landfester, Junfeng Zhang, Shuai Jiang   +11 more
wiley   +1 more source

Targeted systemic delivery of nanocarrier-coated MSC to wound tissues.

, 2016
A. In vivo IVIS imaging shows an increased Ac-G5-dendrimer-sE-sel nanocarrier-coated Luc2+-MSC homed to wound tissues compared to either uncoated Luc2+-MSC or Ac-G5-BSA-coated Luc2+-MSC at various time points. B.
Bo Wang (86769), Zhao-Jun Liu (168517), Sylvia Daunert (587439), Letícia Kovalski (2623045), Sapna Deo (2408800), Emre Dikici (2043049), Omaida C. Velazquez (320006), Victor L. Perez (524545), Runxia Tian (2623048), Pirouz Daftarian (2623051), Diego M. Castilla (2623054)   +10 more
core   +1 more source

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

Advanced Science, EarlyView.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen, Chengxiang Zhang, Junhui Wang, Xichong Zhong, Shihao Chen, Xue Wang, Xiaokun Li, Li Lin   +7 more
wiley   +1 more source

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source

PROTAC‐Engineered Protein/DNA Nanoantigen is a Potent Booster for Dendritic Cell Vaccines in Cancer Immunotherapy

Advanced Science, EarlyView.
A PROTAC‐functionalized protein/DNA‐integrated nanoantigen platform is developed to enhance dendritic cell vaccine potency. By combining a VHL‐recruiting peptide‐modified antigen with a sustained expression plasmid within CaCO3 nanoparticles, this system amplifies cross‐presentation, promotes DC maturation, and elicits robust Th1 and CTL responses ...
Peng Liu, Qiang Chen, Zhe Zhou, Yuekang Xu, Jinyao Li   +4 more
wiley   +1 more source

Plaque‐Hepatic Targeting Nanotherapy Disrupts the PCSK9‐LOX‐1 Axis to Suppress oxLDL in Atherosclerosis

Advanced Science, EarlyView.
Self‑amplifying PCSK9–LOX‑1 feedback axis drives atherosclerotic progression by promoting oxLDL generation and endothelial uptake. A dual‑targeting nanoplatform (siPCSK9@PEAL NPs‑aL) is constructed to simultaneously silence hepatic PCSK9 for lipid lowering and block plaque LOX‑1 for anti‑inflammation.
Yi Duan, Yijie Qiu, Yan Zhu, Quan Wang, Jiangtao Lin, Yourong Duan, Qi Wang, Yi Dong   +7 more
wiley   +1 more source