Results 31 to 40 of about 32,553 (267)
Endosomal Escape of siRNA Polyplexes: A Molecular Dynamics Perspective on Underlying Mechanisms
Advanced Functional Materials, EarlyView.Molecular dynamics simulations reveal distinct endosomal escape mechanisms of siRNA nanoparticles, ranging from electrostatic membrane attachment to hydrophobic membrane fusion. Hydrophobic residues and anionic endosomal lipids emerge as key determinants of membrane disruption, linking molecular interactions to experimental delivery performance and ...
Katharina M. Steinegger +5 more
wiley +1 more source
Carbohydrate Polymer Technologies and ApplicationsDue to the increase in cancer and the necessity for effective therapies with minimum side effects, researchers throughout the world are investigating novel methods for delivering drugs to deal with this deadly disease. Nanocarriers lower side effects and
Fatemeh Mohajjel Jafari +2 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.Engineered red blood cell‐derived extracellular vesicles (eRBCEVs) are synthesized via controlled microfluidic assembly from native RBC lipids, enabling tunable encapsulation of proteins, nucleic acids, nanoparticles, and viral vectors. The platform demonstrates reproducible nanoscale architecture, preserved membrane composition, and functional cargo ...
Chiranth K. Nagaraj +23 more
wiley +1 more source
Molecules, 2016 Bullfrog oil is a natural product extracted from the Rana catesbeiana Shaw adipose tissue and used in folk medicine for the treatment of several diseases. The aim of this study was to evaluate the extraction process of bullfrog oil, to develop a suitable
Lucas Amaral-Machado +11 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.Prostate patient‐derived organoids (PDOs) were established from TURP and biopsy specimens with >90% success and retain key features of their tissues of origin, making them functional avatars for antisense oligonucleotide (ASO) therapy . Transfecting single cells outside the Matrigel matrix and then reconstituting organoids overcomes the 3D delivery ...
Thi Thom Tran +15 more
wiley +1 more source
Next MaterialsLeukemia treatment remains a big challenge correlated with human health. Therefore, a novel nanocarrier based on chitosan (CS)-polyamidoamine (PAMAM) polymers was developed for co-delivery of silver (Ag) nanoparticles and curcumin (Cur) against NALM6 ...
Farideh Ziabakhsh Kalkhoran +3 more
doaj +1 more source
Neural Regeneration Research, 2015 Notch pathway activation maintains neural stem cells in a proliferating state and increases nerve repair capacity. To date, studies have rarely focused on changes or damage to signal transduction pathways during cerebral hemorrhage. Here, we examined the
Wei Zou +6 more
doaj +1 more source
Fisetin in Cancer: Attributes, Developmental Aspects, and Nanotherapeutics
Pharmaceuticals, 2023 Cancer is one of the major causes of mortality, globally. Cancerous cells invade normal cells and metastasize to distant sites with the help of the lymphatic system.
Rachna M. Kumar +6 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.Systematic investigation of antibody orientation strategies in lateral flow immunoassays reveals that a para‐substituted (aminomethyl)phenylboronic acid mediated probe (P‐6) combined with a biotin‐streptavidin test‐line modification achieves a synergistic 14‐ to 19‐fold sensitivity gain over conventional conjugation. Furthermore, multiplexed detection,
Pin‐Hao Wang +5 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.Polymer‐coated IONPs functionalized with IL‐4 display respective neuroactive and anti‐inflammatory actions on neural progenitor cells and macrophages/microglia in vitro. When examined chronically in a rat experimental model of spinal cord injury, rGO scaffolds carrying these nanosystems adequately integrate into the lesion, significantly reduce ...
Julia Martínez‐Ramírez +12 more
wiley +1 more source