Results 111 to 120 of about 6,439 (202)

The chemokine receptor‐like fourth extracellular loop of the apelin receptor differentially regulates apelin and elabela binding and signalling

British Journal of Pharmacology, Volume 183, Issue 18, Page 5641-5656, September 2026.
Abstract Background and Purpose Apelin and Elabela are endogenous ligands of the apelin receptor (apelin receptor/APJ), a GPCR involved in cardiovascular regulation and body fluid homeostasis. The human receptor contains a conserved disulfide bridge linking the N‐terminal domain to extracellular loop 3 (ECL3) via Cys19 and Cys281, forming a structural ...
Chloé Bonef, Hela Bouhsine, Carine Huynh, Marion Chaigneau, Steven Dubois, Mikel Garcia‐Marcos, Catherine Llorens‐Cortes, Denis Servent, Philippe Robin, Hervé Nozach, Isabel Alves, Xavier Iturrioz   +11 more
wiley   +1 more source

Nonnodulating Fagales retain the functional NODULE INCEPTION gene

New Phytologist, Volume 251, Issue 6, Page 3080-3087, September 2026.
NODULE INCEPTION orthologs are present in nonnodulating species in Fagales.
Momona Noda, Momoyo Ito, Kana Miyata, Takuya Suzaki   +3 more
wiley   +1 more source

A versatile Plasmodium falciparum reporter line expressing NanoLuc enables highly sensitive multi-stage drug assays [PDF]

Transgenic luciferase-expressing Plasmodium falciparum parasites have been widely used for the evaluation of anti-malarial compounds. Here, to screen for anti-malarial drugs effective against multiple stages of the parasite, we generate a P.
Kroeze, Hans, Arisawa, Mitsuhiro, Inaoka, Daniel Ken, Miyazaki, Yukiko, Vos, Martijn W., Geurten, Fiona J. A., Soulard, Valerie, Yoshioka, Shohei, Dechering, Koen J., Franke-Fayard, Blandine, Miyazaki, Shinya, Bigeard, Pierre   +11 more
core  

Recovery attempts of recCA09 with engineered combinations of independently emerged resistance mutations (genetic background: recCA09-nanoLuc).

Recovery attempts of recCA09 with engineered combinations of independently emerged resistance mutations (genetic background: recCA09-nanoLuc).
Jeong-Joong Yoon (221027), Richard K. Plemper (221041), Michael G. Natchus (1884760), Robert M. Cox (8029568), Megha Aggarwal (293831), Nicole A. Lieberman (17889630), Alexander L. Greninger (8677377), Elizabeth B. Sobolik (17889633), Carolin M. Lieber (15307134), Hae-Ji Kang (6889463)   +9 more
core   +1 more source

Development of a reverse genetics system for West Nile virus (Kunjin type)

Frontiers in Veterinary Science
Kunjin virus (KUNV), a naturally attenuated strain of West Nile virus (WNV), shares similar transmission modes and hosts—primarily mosquitoes, birds, and horses.
Zhen Wu, Zhen Wu, Zhen Wu, Zhen Wu, Tao Hu, Tao Hu, Tao Hu, Zhou Zhou, Zhou Zhou, Zhou Zhou, Yu He, Yu He, Yu He, Yu He, Tao Wang, Tao Wang, Tao Wang, Mingshu Wang, Mingshu Wang, Mingshu Wang, Renyong Jia, Renyong Jia, Renyong Jia, Dekang Zhu, Dekang Zhu, Dekang Zhu, Mafeng Liu, Mafeng Liu, Mafeng Liu, Xinxin Zhao, Xinxin Zhao, Xinxin Zhao, Qiao Yang, Qiao Yang, Qiao Yang, Ying Wu, Ying Wu, Ying Wu, Shaqiu Zhang, Shaqiu Zhang, Shaqiu Zhang, Juan Huang, Juan Huang, Juan Huang, Xumin Ou, Xumin Ou, Xumin Ou, Xumin Ou, Di Sun, Di Sun, Di Sun, Bin Tian, Bin Tian, Bin Tian, Anchun Cheng, Anchun Cheng, Anchun Cheng, Shun Chen, Shun Chen, Shun Chen, Shun Chen   +60 more
doaj   +1 more source

Rapid generation of HCoV-229E and HCoV-OC43 reporter viruses and replicons for antiviral research

Frontiers in Cellular and Infection Microbiology
IntroductionThe large size of coronavirus genome, along with the instability of certain genomic sequences, makes the construction of reverse genetics for coronaviruses particularly challenging.
Yuyuan Zhang, Jiannan Chen, Hui Feng, Lulu Yang, Liyuan Hu, Yang Gao, Ziqiao Wang, Fei Feng, Jincun Zhao, Ping Zhang, Rong Zhang   +10 more
doaj   +1 more source

Selenoprotein M Inhibits the Replication of Influenza A Virus by Regulating Reactive Oxygen Species Levels

Life
Background: Influenza A virus (IAV) is the major pathogen responsible for influenza pandemics and can cause seasonal influenza outbreaks. In general, viral infection of host cells increases reactive oxygen species (ROS) levels, a process that triggers ...
Minxuan Liu, Jinhui Wang, Weigang Li, Bo Zhao, Yuanyuan Zhang, Qiaoying Zeng, Guangyuan Liu   +6 more
doaj   +1 more source

A Dual-Purpose Real-Time Indicator and Transcriptional Integrator for Calcium Detection in Living Cells. [PDF]

ACS Synth Biol, 2022
Erdenee E, Ting AY.
europepmc   +1 more source

Fluorescent Labeling of NanoLuc

, 2015
Bioluminescence is a natural phenomenon that occurs in bacteria, insects, fungi and some marine species whereby light is emitted by a living organism. This emitted light is generated by a chemical reaction that is catalyzed by a class of enzymes known as
DuPlain, Holly
core  

A NanoLuc-Based Protease Biosensor for Highly Sensitive Detection of Intracellular Protease Activity: Applications to Apoptosis and Coronavirus Infection. [PDF]

Bio Protoc
Arakawa M, Morita E.
europepmc   +1 more source