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A molecular toolbox to modulate gene expression and protein secretion in the bacterial predator Bdellovibrio bacteriovorus. [PDF]
PLoS GenetMihajlovic L +5 more
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Caspase sensors based on NanoLuc
Journal of Biotechnology, 2022Caspases are a family of evolutionary conserved cysteine proteases that play key roles in programmed cell death and inflammation. Among the methods for the detection of caspase activity, biosensors based on luciferases have advantages in genetical encoding and convenience in assay.
Chun-Yang Gan
exaly +3 more sources
Biochemical Society Transactions, 2020 The small engineered luciferase NanoLuc has rapidly become a powerful tool in the fields of biochemistry, chemical biology, and cell biology due to its exceptional brightness and stability. The continuously expanding NanoLuc toolbox has been employed in applications ranging from biosensors to molecular and cellular imaging, and currently includes split
Lieuwe Biewenga +2 more
openaire +3 more sources
Novel NanoLuc-type substrates with various C-6 substitutions
Bioorganic and Medicinal Chemistry Letters, 2020NanoLuc (NLuc)-furimazine bioluminescence system offers several advantages over established systems, including improved stability, smaller size, and >150-fold enhancement in bioluminescence. Herein, we designed and synthesized a series of bioluminescent substrates with varying at the C-6 position of furimazine for NLuc-furimazine bioluminescence system.
Lupei Du, Minyong Li
exaly +3 more sources
Highly Potent Cell-Permeable and Impermeable NanoLuc Luciferase Inhibitors
ACS Chemical Biology, 2017 Novel engineered NanoLuc (Nluc) luciferase being smaller, brighter, and superior to traditional firefly (Fluc) or Renilla (Rluc) provides a great opportunity for the development of numerous biological, biomedical, clinical, and food and environmental safety applications.
Joel R. Walker +7 more
openaire +3 more sources
A Split NanoLuc Reporter Quantitatively Measures Circular RNA IRES Translation
Genes, 2022 Internal ribosomal entry sites (IRESs) are RNA secondary structures that mediate translation independent from the m7G RNA cap. The dicistronic luciferase assay is the most frequently used method to measure IRES-mediated translation.
Shu-Jun Lin +2 more
exaly +3 more sources
Evaluation of NanoLuc, RedLuc and Luc2 as bioluminescent reporters in a cutaneous leishmaniasis model [PDF]
Acta Tropica, 2020 New drugs for the treatment of human leishmaniasis are urgently needed, considering the limitations of current available options. However, pre-clinical evaluation of drug candidates for leishmaniasis is challenging.
Helen P Price, Silvia R B Uliana
exaly +2 more sources
NanoLuc Luciferase as a Fluorogen-Activating Protein for GFP Chromophore Based Fluorogens
International Journal of Molecular Sciences, 2023 In this work, we showed that the well-known NanoLuc luciferase can act as a fluorogen activating protein for various arylidene-imidazolones structurally similar to the Kaede protein chromophore.
Alexander Yu Smirnov +2 more
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A NanoLuc-Based Transactivation Assay in Plants
2023Protein-DNA interactions are determinant of the regulation of gene expression in living organisms. Luminescence studies have been used in a wide range of techniques to identify how gene transcription can be regulated by proteins such as transcription factors (TFs).
Rosa Esmeralda, Becerra-García +4 more
openaire +2 more sources