Results 21 to 30 of about 70,205 (303)

Pore Structures for High-Throughput Nanopore Devices

Micromachines, 2020
Nanopore devices are expected to advance the next-generation of nanobiodevices because of their strong sensing and analyzing capabilities for single molecules and bioparticles. However, the device throughputs are not sufficiently high.
Sou Ryuzaki, Rintaro Matsuda, Masateru Taniguchi   +2 more
doaj   +1 more source

Barcode demultiplexing of nanopore sequencing raw signals by unsupervised machine learning

Frontiers in Bioinformatics, 2023
Introduction: Oxford Nanopore Technologies (ONT) is a third generation sequencing approach that allows the analysis of individual, full-length nucleic acids. ONT records the alterations of an ionic current flowing across a nano-scaled pore while a DNA or
Daniele M. Papetti, Simone Spolaor, Simone Spolaor, Iman Nazari, Iman Nazari, Andrea Tirelli, Andrea Tirelli, Tommaso Leonardi, Chiara Caprioli, Chiara Caprioli, Daniela Besozzi, Daniela Besozzi, Thalia Vlachou, Pier Giuseppe Pelicci, Pier Giuseppe Pelicci, Paolo Cazzaniga, Paolo Cazzaniga, Marco S. Nobile, Marco S. Nobile, Marco S. Nobile   +19 more
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Nanopores: general discussion

Faraday Discussions, 2016
Legacy description not ...
Andrew Mount, Minkyung Kang, Paolo Actis, Olaf Magnussen, Lane Baker, Philip Bartlett, Sanli Faez, Jan Clausmeyer, Bradley Thomas, Philip A. Ash, Frederic Kanoufi, Yitao Long, David Fermin, Patrick Unwin, Marc Koper, Serge Lemay, Andrew Ewing, Zhongqun Tian, Robert Johnson, Michael Eikerling, Mark Platt, Tim Albrecht, J. Gooding, Richard Crooks, Nongjian Tao, Wolfgang Schmickler, Julie MacPherson, Shengli Chen   +27 more
openaire   +5 more sources

Single molecule sensing by nanopores and nanopore devices [PDF]

The Analyst, 2010
Molecular-scale pore structures, called nanopores, can be assembled by protein ion channels through genetic engineering or be artificially fabricated on solid substrates using fashion nanotechnology. When target molecules interact with the functionalized lumen of a nanopore, they characteristically block the ion pathway.
Li-Qun, Gu, Ji Wook, Shim
openaire   +2 more sources

De-novo Assembly of Limnospira fusiformis Using Ultra-Long Reads

Frontiers in Microbiology, 2021
The Limnospira genus is a recently established clade that is economically important due to its worldwide use in biotechnology and agriculture. This genus includes organisms that were reclassified from Arthrospira, which are commercially marketed as ...
McKenna Hicks, Thuy-Khanh Tran-Dao, Logan Mulroney, David L. Bernick   +3 more
doaj   +1 more source

Nanopore-Based Protein Identification

, 2022
The implementation of a reliable, rapid, inexpensive, and simple method for whole-proteome identification would greatly benefit cell biology research and clinical medicine.
Mazdak Afshar Bakshloo, Manuela Pastoriza-Gallego, Abdelghani Oukhaled, Jérôme Mathé (2027461), Fabien Piguet (1347387), Régis Daniel, Mazdak Afshar Bakshloo (8982782), Abdelghani Oukhaled (1297608), Jérôme Mathé, John J. Kasianowicz, Fabien Piguet, John J. Kasianowicz (1546549), Manuela Pastoriza-Gallego (1763653), Régis Daniel (1911106)   +13 more
core   +1 more source

Crystal structure of an invertebrate cytolysin pore reveals unique properties and mechanism of assembly

Nature Communications, 2016
Pore-forming toxins act by forming oligomeric pores in lipid membranes. Here the authors report the crystal structure of the lysenin pore, providing insights into the assembly and function of the pore in addition to suggesting that its properties make ...
Marjetka Podobnik, Peter Savory, Nejc Rojko, Matic Kisovec, Neil Wood, Richard Hambley, Jonathan Pugh, E. Jayne Wallace, Luke McNeill, Mark Bruce, Idlir Liko, Timothy M. Allison, Shahid Mehmood, Neval Yilmaz, Toshihide Kobayashi, Robert J. C. Gilbert, Carol V. Robinson, Lakmal Jayasinghe, Gregor Anderluh   +18 more
doaj   +1 more source

Interchromosomal template-switching as a novel molecular mechanism for imprinting perturbations associated with Temple syndrome

Genome Medicine, 2019
Background Intrachromosomal triplications (TRP) can contribute to disease etiology via gene dosage effects, gene disruption, position effects, or fusion gene formation.
Claudia M. B. Carvalho, Zeynep Coban-Akdemir, Hadia Hijazi, Bo Yuan, Matthew Pendleton, Eoghan Harrington, John Beaulaurier, Sissel Juul, Daniel J. Turner, Rupa S. Kanchi, Shalini N. Jhangiani, Donna M. Muzny, Richard A. Gibbs, Baylor-Hopkins Center for Mendelian Genomics, Pawel Stankiewicz, John W. Belmont, Chad A. Shaw, Sau Wai Cheung, Neil A. Hanchard, V. Reid Sutton, Patricia I. Bader, James R. Lupski   +21 more
doaj   +1 more source

MasterOfPores: A Workflow for the Analysis of Oxford Nanopore Direct RNA Sequencing Datasets

Frontiers in Genetics, 2020
The direct RNA sequencing platform offered by Oxford Nanopore Technologies allows for direct measurement of RNA molecules without the need of conversion to complementary DNA, fragmentation or amplification.
Luca Cozzuto, Huanle Liu, Leszek P. Pryszcz, Leszek P. Pryszcz, Toni Hermoso Pulido, Anna Delgado-Tejedor, Anna Delgado-Tejedor, Julia Ponomarenko, Julia Ponomarenko, Eva Maria Novoa, Eva Maria Novoa, Eva Maria Novoa, Eva Maria Novoa   +12 more
doaj   +1 more source

LAFITE Reveals the Complexity of Transcript Isoforms in Subcellular Fractions

Advanced Science, 2023
Characterization of the subcellular distribution of RNA is essential for understanding the molecular basis of biological processes. Here, the subcellular nanopore direct RNA‐sequencing (DRS) of four lung cancer cell lines (A549, H1975, H358, and HCC4006)
Jizhou Zhang, Xiao Lin, Yuelong Chen, Tsz‐Ho Li, Alan Chun‐Kit Lee, Eugene Yui‐Ching Chow, William Chi‐Shing Cho, Ting‐Fung Chan   +7 more
doaj   +1 more source